Glimerilm M Tablet

Adult dose

This medication is administered 1-2 times daily before meals or with meals. Typically, treatment is initiated with a low dose, and the dosage can be adjusted based on the patient's current medication and blood glucose levels. In clinical trials, the initial daily dose was glibenclamide/metformin hydrochloride 2mg/500mg, and it has been gradually increased up to 8mg/2000mg. When using single-agent glibenclamide, generally, additional effects are minimal when doses exceed 4mg daily; however, some patients showed better metabolic control when increasing to 6mg (or 8mg).

This medication can cause severe lactic acidosis or hypoglycemia, so caution is required. Particularly, when kidney function declines rapidly, metformin may accumulate in the body, increasing the risk of lactic acidosis. If dehydration symptoms, severe diarrhea, vomiting, fever, etc. occur, this medication should be temporarily discontinued, and a doctor should be consulted. Also, caution should be exercised when taking this medication with other drugs that may affect kidney function. Excessive alcohol consumption, liver dysfunction, uncontrolled diabetes, ketoacidosis, prolonged fasting, and hypoxia also require attention in the use of this drug. This drug should not be used in patients with insulin-dependent diabetes or acute metabolic acidosis, severe liver dysfunction, women who are pregnant or breastfeeding, and patients with moderate to severe renal impairment. Patients undergoing radiological iodinated contrast examinations should also discontinue the use of this drug for a certain period before and after the examination. Careful administration is necessary for patients with severe infections, before and after surgery, nutritional deficiency, and serious circulatory and respiratory diseases. In the initial stages of treatment, the risk of hypoglycemia is high, so patients with irregular meal intake, frequent alcohol consumption, impaired kidney function, or severely reduced liver function should be carefully monitored. If gastrointestinal disturbances, skin rashes, symptoms of hypoglycemia, or symptoms of lactic acidosis occur while taking this medication, immediate consultation with a doctor is necessary, and emergency treatment may be required in case of severe hypoglycemia or serious allergic reactions. It is important to routinely monitor blood sugar control status and periodically perform kidney function and hematological tests to detect any abnormal signs early. In cases of overdose, hypoglycemia or lactic acidosis may occur, so the dosage should not be arbitrarily increased or decreased without a doctor's instruction, and in case of overdose, immediate medical attention should be sought. During pregnancy or breastfeeding, this medication should not be used, and insulin therapy is recommended if necessary. This drug may interact with other medications, so inform healthcare professionals of all medications being taken and manage them carefully. Finally, keep this medication out of the reach of children and do not transfer it to other containers.

Serious side effects

• Hives, severe swelling (edema), difficulty breathing, chest tightness, hypotension, shock
• Severe allergic reactions
• Liver abnormalities (liver function impairment, jaundice)
• Lactic acidosis: decrease in blood pH, increase in plasma lactate concentration, increase in anion gap
• Severe neurological symptoms: headache, coma, visual disturbances, paralysis, confusion
• Cardiovascular abnormalities: cardiac arrest
• Hypoglycemia: coma, seizures, loss of consciousness, delirium
• Hematological abnormalities: thrombocytopenia

Mild side effects

• Gastrointestinal symptoms: diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, dyspepsia, constipation, abdominal pain, sensations of fullness or pressure in the upper abdomen
• Specific sensory symptoms: discomfort, metallic taste, visual impairment, taste disorder
• Skin reactions and hypersensitivity: erythema, itching, rash
• Hematological abnormalities: thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia
• Reduced vitamin B12 and deficiency-related issues

Store this medication in a tightly closed container to prevent air or moisture from entering, and it is recommended to keep it at room temperature between 1 to 30 degrees Celsius. Storing it this way can maintain the medication's efficacy and prevent degradation.

Appearance

White, oblong, film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle