Olmesartan Medoxomil 20 mg Tablets

Adult dose

The recommended initial dose is 10 mg once daily, regardless of meals. If blood pressure is not adequately controlled, the dose can be increased to 20 mg once daily. If further blood pressure reduction is required, the dose can be increased to a maximum of 40 mg once daily. The blood pressure-lowering effect appears within 2 weeks after treatment initiation and the maximum effect is observed in about 8 weeks. If blood pressure is not controlled with monotherapy, thiazide diuretics such as hydrochlorothiazide may be used in combination. To improve adherence, it is advisable to take the medication at the same time daily (e.g., in the morning). For patients who may experience decreased intravascular effective blood volume (e.g., those receiving diuretics, especially patients with renal impairment), it is recommended to closely monitor their condition and initiate treatment at a lower dose. <Elderly> No dose adjustment is necessary when administering this medication to elderly patients aged 65 years and older. While there were no significant overall differences in efficacy and safety between elderly and younger patients, it cannot be excluded that some elderly individuals may exhibit more sensitive reactions. <Patients with renal impairment> For patients with mild to moderate renal impairment (creatinine clearance 20-60 mL/min), the maximum dose is 20 mg once daily. <Patients with liver impairment> Mild liver impairment does not require dose adjustment. For moderate liver impairment, the recommended initial dose is 10 mg once daily, with a maximum increase to 20 mg daily. There is no experience using this drug in severe liver impairment, so its use is not recommended. <Children> Safety and efficacy in children have not been established.

Child dose

Safety and efficacy in children have not been established.

This medication can cause serious harm or death to the fetus and newborn if taken during the second and third trimesters of pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Patients with allergies to any component of this drug, pregnant or breastfeeding women, patients undergoing kidney dialysis, patients with severe liver dysfunction, patients with biliary obstruction, and patients with lactose intolerance should not take this medication. Patients with low blood volume or sodium may experience low blood pressure at the start of treatment, so caution is needed; if low blood pressure occurs, the patient should be laid down, and normal saline should be administered if necessary. Patients with impaired kidney function, those who have received kidney transplants, patients with renal artery hypertension, patients at risk for hyperkalemia, and patients with aortic or mitral stenosis should be closely monitored when taking this medication. This medication may cause side effects such as dizziness, so care should be taken when performing hazardous activities like working at heights or driving. According to clinical trial results, this medication has generally been safely used, with most side effects being mild and transient, but occasionally symptoms like chest pain, peripheral edema, dizziness, abdominal pain, palpitations, skin rashes may appear. If serious gastrointestinal symptoms like chronic diarrhea or weight loss occur, this medication should be discontinued, and a doctor should be consulted. Caution is needed when taken with potassium-sparing diuretics or potassium supplements, as blood potassium levels may become dangerously high, and the blood pressure-lowering effect may be enhanced when combined with other antihypertensives. Co-administration with lithium formulations may increase lithium levels and result in toxicity, so it is not recommended to take this drug and lithium together. When taken with non-steroidal anti-inflammatory drugs, the risk of worsening renal function may increase, so regular hydration and kidney function tests are recommended. When using this medication with other drugs that act on the angiotensin system, blood pressure, kidney function, and electrolyte status should be closely monitored, and patients with diabetes or moderate to severe renal impairment should not use specific medications in combination. This medication may be passed into breast milk, so breastfeeding women should either discontinue breastfeeding or stop taking the medication. Safety and efficacy in children have not been sufficiently established, so caution is advised for their use. Elderly patients may have higher plasma concentrations of this medication than younger individuals, so caution is necessary during use. In the event of overdose, symptoms such as low blood pressure, palpitations, and bradycardia may occur, and appropriate treatment should be provided based on symptoms. Although carcinogenicity or genotoxicity have not been reported with long-term administration, there may be rare instances of chromosomal changes or immune system abnormalities, thus regular testing is recommended.

Serious side effects

Urticaria, severe swelling (angioedema), chest pain, vascular swelling, anaphylaxis, severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain, difficulty breathing, asthma attack, respiratory issues accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, severe liver dysfunction, sudden and severe headache, seizures, confusion, vision abnormalities, paralysis, significantly reduced urine output

Mild side effects

• Dizziness
• headache
• palpitations
• lower back pain
• hematuria
• hyperglycemia
• hypertriglyceridemia
• flu-like symptoms
• pharyngitis
• rhinitis

Store this medication in a tightly closed container to prevent air or moisture from entering. The suitable storage temperature is a cool place between 1 degrees and 25 degrees.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle