Omethan Tablet 10mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose is 10 mg once daily, regardless of meals. If blood pressure is not adequately controlled, it can be increased to 20 mg once daily. If further blood pressure reduction is needed, it may be increased up to a maximum of 40 mg once daily. The blood pressure-lowering effect appears within 2 weeks after initiation, with maximum effect occurring around 8 weeks. If blood pressure remains uncontrolled with this medication alone, it may be combined with thiazide diuretics such as hydrochlorothiazide. For compliance improvement, it is recommended to take it at the same time every day (e.g., in the morning). Patients with the potential for intravascular volume depletion (e.g., patients on diuretics, especially those with renal impairment) should start treatment at a lower dose while being adequately monitored. <Elderly> No dose adjustment is necessary for elderly patients aged 65 years and older. No overall differences in efficacy and safety have been observed between elderly and younger patients, although some elderly patients may exhibit a more sensitive response. <Patients with Renal Impairment> The maximum dosage for patients with mild to moderate renal impairment (creatinine clearance 20-60 mL/min) is 20 mg once daily. <Patients with Liver Impairment> Mild liver impairment does not require dosage adjustments. In patients with moderate liver impairment, the recommended initial dose is 10 mg once daily, which may be increased up to a maximum of 20 mg daily. There is no experience with the use in severe liver impairment, so the administration of this medication is not recommended. <Pediatric Patients> Safety and efficacy in pediatric patients have not been established.

Child dose

Safety and efficacy in pediatric patients have not been established.

This medication can cause serious harm or death to the fetus and newborn if taken during the second and third trimesters of pregnancy, so if pregnancy is confirmed, it should be stopped immediately. Patients with allergies to any of the ingredients in this medication, pregnant women, nursing mothers, patients undergoing kidney dialysis, patients with severe liver impairment, patients with bile duct obstruction, certain genetically lactose-intolerant patients, and certain diabetic patients or patients with severely impaired kidney function should not take this medication. Patients with reduced blood volume or low salt levels may experience a sudden drop in blood pressure during the initial stages of taking this medication, so sufficient precaution and monitoring of their condition are necessary before administration. Additionally, careful monitoring is crucial for patients with severe heart failure or those reliant on kidney function as there is an increased risk of worsening kidney function. Patients with reduced kidney function or those who have had a kidney transplant should have regular tests for potassium and creatinine levels while taking this medication, and it is not recommended for patients with severe kidney impairment. Patients with renovascular hypertension may also experience worsening kidney function, so caution is advised. This medication can cause hyperkalemia, necessitating regular checks of potassium levels in patients with heart failure or kidney disease. Patients with aortic or mitral stenosis, and obstructive heart disease require special caution while taking this medication. Patients with primary aldosteronism may have a reduced effect from this medication, so it is not recommended for them. As blood pressure may drop and cause dizziness, care should be taken when driving or operating hazardous machinery. This medication may have a reduced effect on blood pressure in African American patients. Possible side effects that may occur during administration include dizziness, headaches, back pain, dyspepsia, cough, chest pain, peripheral edema, which are mostly mild and temporary. Abnormal liver function or changes in blood test values have been reported infrequently, so any unusual symptoms should be discussed with a healthcare professional. In rare cases, chronic diarrhea or intestinal tissue damage may occur with long-term use of this medication, so if severe diarrhea or weight loss occurs, it should be stopped immediately and medical attention sought. Taking this medication in combination with potassium-sparing diuretics or potassium supplements may dangerously elevate serum potassium levels, so caution is required when used together. Combining this medication with other antihypertensive agents may enhance blood pressure-lowering effects, therefore blood pressure should be regularly monitored. When taken with lithium, increased lithium levels and toxicity may occur, so co-administration should be avoided. Taking this medication alongside non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of kidney dysfunction, necessitating adequate fluid intake and monitoring of kidney function. Using this medication along with other drugs that exert similar effects may increase the risks of hypotension, hyperkalemia, and worsening kidney function, necessitating frequent blood pressure and blood tests. There are serious risks to fetuses and newborns during pregnancy, so any patients who are pregnant or planning to become pregnant should consult with healthcare professionals. In nursing mothers, this medication may be transmitted through breast milk and cause side effects in infants, so either breastfeeding should be stopped or medication use discontinued. Safety and efficacy in pediatric patients have not been established, so it is generally advised not to administer to children. Elderly patients may have increased body concentration of this medication, necessitating dosage adjustments and careful monitoring. In cases of overdose, symptoms may include hypotension and palpitations, and appropriate treatment should be received if necessary.

Serious side effects

Urticaria, angioedema, anaphylactic reaction, intestinal vascular edema, rhabdomyolysis, hyperkalemia, acute renal failure, elevated serum creatinine levels, urticaria, liver dysfunction (increased transaminases or total bilirubin), severe allergic reactions, severe skin reactions, respiratory issues, liver issues (jaundice), severe neurological symptoms, severe edema or urinary disturbances

Mild side effects

• Dizziness
• headaches
• palpitations
• back pain
• hematuria
• hyperglycemia
• hypertriglyceridemia
• flu-like symptoms
• pharyngitis
• rhinitis

This medication should be stored in a tightly closed container to prevent air and moisture entry, and it is best stored at room temperature between 1 degree and 25 degrees Celsius. This will help maintain the medication's efficacy over time.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle