Systen Injection (Acetylcysteine)

Adult administration

Mucolytic: Inject acetylcysteine 600–900mg once, 2–3 times a day. Antidote for paracetamol poisoning: Initially, intravenous infusion of 150mg/kg diluted in 200mL of 5% glucose solution over 15 minutes, followed by 50mg/kg diluted in 500mL of 5% glucose solution over 4 hours. Finally, inject 100mg/kg diluted in 1000mL of 5% glucose solution over 16 hours.

Child administration

Mucolytic: Inject acetylcysteine 300–450mg once, 2–3 times a day. Antidote for paracetamol poisoning: Inject 150mg intramuscularly once, 1–2 times a day.

This medication may contain glass particles when using ampoule injections, so caution is required when cutting the container. Extra caution is necessary when this medication is used by children or elderly patients. Those who have had allergic reactions to this drug should not use it. Patients with bronchial asthma or poor respiratory function should exercise caution, as this medication may induce bronchospasm; it should only be administered after careful consideration, and if adverse reactions occur, use should be immediately discontinued, and appropriate treatment sought. It is advisable not to administer this drug to newborns unless they are severely ill. Occasionally, gastrointestinal symptoms such as nausea, vomiting, loss of appetite, and diarrhea may occur with this medication. Rarely, hives, itching, rashes, headaches, tinnitus, bronchospasm, etc. may develop, warranting caution. Very rarely, rapid heart rate or high blood pressure may occur, and severe allergic reactions such as anaphylaxis may manifest. Care must be taken when administering large amounts intravenously as an antidote, as symptoms similar to hypersensitivity reactions or severe hypertension may occur, and its administration should be stopped immediately if abnormal symptoms arise. Symptoms such as respiratory distress or vascular swelling have been reported during the use of this medication; therefore, medical personnel should be informed immediately if any unusual symptoms arise. Increased bronchial secretions may occur; thus, patient status should be closely monitored, and if phlegm does not come out naturally, appropriate measures such as mechanical suction or position changes should be taken. When administering an intramuscular injection, it should be deep. When used for detoxification treatment, it is preferable to administer it as soon as possible after poisoning, usually within 10 hours. This drug may interact physically and chemically with certain local anesthetics, bronchodilators, some antibiotics, sympathomimetics, and hormones, so caution should be taken when administering them together. Pregnant women should use this medication only when necessary as its safety has not been sufficiently proven. Nursing women should also be cautious as it is not known whether this drug passes into breast milk. The elderly may have diminished physical function, so care should be taken to observe their condition.

Serious side effects

• Hives
• bronchospasm
• anaphylaxis
• respiratory distress
• vascular swelling

Mild side effects

• Nausea
• vomiting
• loss of appetite
• diarrhea
• itching
• rashes
• headaches
• tinnitus
• tachycardia
• hypertension

This drug may be light-sensitive, so it should be stored in a dark container that does not allow light to enter. Additionally, it is important to store it at room temperature between 1 and 30 degrees Celsius to maintain its effectiveness.

Appearance

Brown transparent ampoule injection filled with a colorless transparent liquid

Package unit

1 ampoule (3mL) x company packaging unit