Subast Tablets 10 mg (Rosuvastatin Calcium)

Adult dose

The initial dose is 5 mg orally once daily, and if a greater reduction in LDL cholesterol is needed, the maintenance dose can be adjusted. The maintenance dose is typically 10 mg orally once daily, which is adequate for most patients. The maintenance dose should be appropriately adjusted based on LDL cholesterol levels, treatment goals, and patient response, every 4 weeks or longer interval, with a maximum daily dose of 20 mg.

Child dose

The usual dosage range for pediatric patients with heterozygous familial hypercholesterolemia (aged 10 to 17 years) is 5 mg to 20 mg, taken once daily. The administered dose should be individually adjusted based on recommended treatment goals.

This medication should not be administered to certain patients. For example, patients allergic to any ingredient of this medication, those with severe liver dysfunction, those with muscle diseases, and pregnant or breastfeeding women should not take this drug. Also, caution is necessary for patients with severely impaired kidney function or those taking specific medications together. This medication can affect liver function; therefore, patients with a history of liver disease or those who consume large amounts of alcohol should undergo liver function tests before use and regularly during treatment. If symptoms of muscle pain or weakness occur, consult a physician immediately and discontinue use if necessary. Special caution is needed for high-dose use, as the risk of muscle-related side effects increases. Since genetic factors or higher body volumes may increase concentration in Asians, dose adjustments may be necessary. Women who may become pregnant should use appropriate contraceptive methods, and this medication should not be taken during pregnancy. During the use of this medication, there is a risk of interactions with other drugs; therefore, inform healthcare professionals of all medications being taken. In case of overdose, there is no specific antidote, so immediately seek medical treatment according to symptoms. Be cautious as dizziness may occur while driving or operating machinery. This medication can rarely cause severe skin reactions, liver damage, and kidney problems; thus, if abnormal symptoms occur, consult healthcare professionals immediately.

Serious side effects

Allergic reactions including hives and angioedema, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), jaundice, hepatitis, polyneuropathy, severe muscle weakness, shortness of breath, ophthalmoplegia, acute renal failure, oliguria, myopathy, rhabdomyolysis, immune-mediated necrotizing myopathy, severe skin reactions, severe swelling, severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain.

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• rash
• muscle pain
• weakness
• hematuria

This medication must be stored in a tightly closed container to avoid exposure to air or moisture, and should ideally be stored at room temperature between 1°C to 30°C. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/box [15 tablets/PTP/X2], 300 tablets/bottle