Subastin Tablet (Rosuvastatin Calcium)

Adult dose

It can be administered at any time of day regardless of meals. The initial dose is 5 mg once daily, and the maintenance dose can be adjusted as needed. The maintenance dose of 10 mg once daily is suitable for most patients. The maintenance dose should be adjusted at intervals of 4 weeks or more according to LDL cholesterol levels and patient response, with a maximum daily dose of 20 mg possible.

Child dose

The usual dosage range for pediatric patients aged 10 to 17 years is 5 mg to 20 mg once daily. The dosage should be individually adjusted according to the recommended therapeutic target, with adjustments made at intervals of 4 weeks or more.

This drug should not be used in certain patients. For example, patients who have allergies to any ingredient of this drug, those with severely impaired liver function, those with muscle diseases, those with severely reduced kidney function, and women who are pregnant or breastfeeding should not take this medication. Additionally, high-dose administration is prohibited for patients at high risk of muscle-related side effects. This drug contains lactose, so patients with lactose intolerance should avoid it. It is important to periodically monitor liver function and muscle condition while taking this medication. Special caution is necessary for patients with a history of liver disease, those who consume large amounts of alcohol, and patients with hypothyroidism. If symptoms such as muscle pain, weakness, or cramps occur, inform a doctor immediately and undergo checks. This drug can rarely cause serious side effects such as severe skin reactions, liver damage, and myopathy, so if any unusual symptoms occur, discontinue use immediately and consult healthcare professionals. This medication may interact with other drugs, so inform healthcare providers of any medications being taken. In particular, taking it with certain antiviral drugs, immunosuppressants, or fibrates may increase the risk of muscle side effects. Women who may become pregnant must use appropriate contraceptive methods before taking this medication and should not take it while pregnant. It is also advisable to avoid this medication while breastfeeding. In the case of overdose, there are no specific antidotes, so treatment should be symptomatic, and liver function and muscle enzyme levels should be monitored. Caution is advised while driving or operating machinery as dizziness may occur. Finally, the drug concentration may be higher in Asians, so dosage adjustment may be necessary.

Serious side effects

Allergic reactions including hives and angioedema, severe swelling (edema), chest tightness, difficulty breathing, Stevens-Johnson syndrome, eosinophilia and systemic symptoms associated drug reaction syndrome (DRESS), severe rash with fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, rhabdomyolysis, severe swelling or urination abnormalities (acute kidney failure, oliguria), liver abnormalities (jaundice), sudden and severe headache, and others

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• weakness
• diarrhea
• chest discomfort

This medication should be stored in a tightly sealed container to protect it from air and moisture. The storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius, avoiding extremes of hot or cold.

Appearance

Pink round film-coated tablet

Package unit

Bottle - 30 tablets/bottle