Paksar Tablet 2mg (Lacidipine)

Adult dose

1. Adults The therapeutic dose of this medicine should be adjusted appropriately according to the patient's response and severity of symptoms. The initial dose is 2 mg of lacidipine once daily. Take it at the same time each day, preferably in the morning, with or without food. If a dose increase is needed, increase to 4 mg once daily after an appropriate period has elapsed to allow adequate assessment of the pharmacologic effect. Increase to 6 mg once daily only if blood pressure is not controlled with 4 mg once daily. Except in patients requiring more rapid titration, the period before deciding to increase the dose should be at least 3 ～ 4 weeks, the time required for this medicine to achieve its full pharmacologic effect. If an adequate response is not achieved, another antihypertensive agent may be added (a beta-blocker and/or a diuretic). 2. Patients with hepatic impairment Because this medicine is metabolized primarily in the liver, its bioavailability and blood pressure-lowering effect may be increased in patients with hepatic impairment. These patients should be monitored carefully, and a reduction in the initial dose is recommended. 3. Patients with renal impairment As this medicine is not excreted through the kidneys, dosage adjustment is not necessary in patients with renal impairment. 4. Elderly patients The initial dose is 2 mg once daily. If necessary, it may be increased to 4 mg once daily after 4 weeks.

Child dose

There is no experience with the use of this medicine in children.

This drug should not be used in certain patients. Individuals allergic to this drug, its ingredients, or similar drugs should not use it. Pregnant women, women who may become pregnant, and nursing mothers should not take this drug. Patients in a state of cardiogenic shock or unstable angina should also refrain from using this drug. It is contraindicated in patients with aortic stenosis as it may reduce blood flow. Patients who have recently suffered a myocardial infarction or are in the midst of a myocardial infarction should not take this drug, nor should patients with left ventricular dysfunction. Additionally, this drug should not be administered to patients taking a medication called dantrolene. This drug contains lactose, so patients with lactose intolerance or certain genetic disorders should not take it. Use this drug cautiously in patients with sinoatrial node or atrioventricular node dysfunction, decreased cardiac reserve, or liver impairment. Caution is also needed in patients with prolonged QT interval and those with unstable angina. While taking this drug, mild side effects such as dizziness or headache may occur, and various symptoms including palpitations, flushing, abdominal discomfort, and skin rash have been reported. These side effects are usually temporary and resolve over time. Particularly in patients with cardiovascular diseases, angina may worsen, so it is important to consult a doctor immediately if any symptoms occur. Abruptly stopping the drug may worsen symptoms, so when discontinuing, it should be done gradually under a doctor's guidance. This drug can affect the sinoatrial node and atrioventricular node, so patients with existing cardiac conduction issues should be cautious. When starting treatment, blood pressure may drop, and heart rate may temporarily accelerate, thus monitoring is necessary. Caution is advised when taking this drug with other antihypertensive agents, as it can further lower blood pressure, and potential interactions with certain medications should be disclosed to the physician regarding currently taken medications. It is advisable to avoid grapefruit juice as it may alter the drug's effects. Pregnant or nursing women should not take this drug, as animal studies have reported risks such as uterine muscle relaxation and delayed delivery. Safety in children has not been established, hence it should not be administered to children. In the case of overdose, low blood pressure and heart rhythm abnormalities may occur, and as there is no specific antidote, immediate medical attention should be sought. This drug should be kept out of reach of children, and it is advisable not to transfer it to other containers.

• Dizziness
• headache
• mood disorders
• tremors
• depression
• palpitations
• tachycardia
• flushing
• worsening of pre-existing angina
• syncope

This drug is sensitive to light, so it should be stored in a container that blocks light. Additionally, it is best to store the drug at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the drug’s effectiveness.

Appearance

White, biconvex, round film-coated tablet

Package unit

28 tablets (7 tablets/PTP x 4)