Neumentamin Sustained Release Capsule 8 mg (Galantamine Hydrobromide)

Adult dose

[Adults] Administer once daily in the morning. Administration immediately after breakfast is preferred. Swallow this medicine whole with an adequate amount of water; do not chew or crush it. Ensure adequate fluid intake while taking this medicine. Initial dose: 8mg once daily is recommended for the first 4 weeks. Maintenance dose: - After the initial dose, administer 16mg once daily for at least 4 weeks. - Thereafter, based on evaluation of clinical benefit and tolerability, the dose may be increased to a maximum of 24mg daily. - For patients who do not tolerate 24mg daily or whose response does not improve, consider reducing the dose to 16mg daily. - This medicine may be continued for as long as it benefits the patient. Regularly evaluate the clinical benefit of this medicine and consider discontinuing treatment if there is no therapeutic effect. - No rebound effects occur after treatment is discontinued (e.g., in preparation for surgery). [Patients with renal or hepatic impairment] Galantamine blood concentrations may increase in patients with moderate to severe renal or hepatic impairment. Based on pharmacokinetic modeling, patients with moderate hepatic impairment should receive 8mg every other day for at least 1 week, preferably in the morning. Thereafter, administer 8mg once daily for at least 4 weeks. Do not exceed 16mg daily. This medicine is contraindicated in patients with severe hepatic impairment (Child-Pugh score >9). No dose adjustment is necessary in patients with mild hepatic impairment. No dose adjustment is necessary in patients with creatinine clearance of 9mL/min or higher. This medicine is contraindicated in patients with severe renal impairment (creatinine clearance < 9mL/min). [Concomitant therapy] Consider reducing the dose of this medicine in patients receiving CYP 2D6 or CYP 3A4 inhibitors (e.g., ketoconazole).

Child dose

Use in children is not recommended.

This medication should not be used in patients with hypersensitivity to its ingredients, severe liver disease, or severe kidney disease. While taking this medication, side effects such as nausea, vomiting, dizziness, headache, and bradycardia may occur, so consultation with a healthcare professional is advised if symptoms arise. In particular, if a rash or severe allergic reaction occurs, the medication should be discontinued immediately and medical attention sought. This medication is used for patients with mild to moderate Alzheimer's type dementia, and its effectiveness has not been proven for other types of dementia or memory disorders. Patients with heart disease, low heart rate, history of peptic ulcer, asthma, or lung disease should use this medication with caution. Additionally, it is advisable not to take this medication with other cholinergic drugs, as co-administration with substances that inhibit certain liver enzymes may increase side effects. Pregnant or breastfeeding women should consult a physician before using this medication. During the first week of taking this medication, dizziness or drowsiness may occur, so caution is advised when driving or operating machinery. In case of overdose, severe nausea, vomiting, muscle weakness, bradycardia, and hypotension may occur, requiring immediate emergency treatment. Keep out of reach of children and avoid transferring to other containers.

Decreased appetite, depression, dizziness, headache, tremors, fainting, drowsiness, sleepiness, bradycardia, nausea, vomiting, diarrhea, abdominal pain, upper abdominal pain, indigestion, abdominal discomfort, muscle cramps, fatigue, asthenia, apathy, weight loss, falls, laceration, dehydration, dysgeusia, hypersomnia, sensory disturbance, blurred vision, I-degree atrioventricular block, palpitations, tachybradycardia, ventricular premature contractions, flushing, hypotension, nausea, hyperhidrosis, muscle weakness, hypersensitivity, hallucinations, visual hallucinations, auditory hallucinations, convulsions, tinnitus, complete heart block, hypertension, hepatitis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, increased liver enzymes, rash, pruritus, extrapyramidal syndrome, Parkinson's syndrome, exacerbation of Parkinson's syndrome, hand paralysis, bradykinesia, Pierre Robin syndrome, delirium, sweating, edema, constipation, polydipsia, gastritis, belching, jaundice, elevated γ-GT, elevated ALT/AST, exacerbation of chronic kidney failure, urinary incontinence, vertigo, sweating, gastrointestinal cramps, drooling, tearing, bowel movement, urination, prostration, bronchial hypersecretion, bronchospasm, Torsades de Pointes, QT prolongation, ventricular tachycardia, brief loss of consciousness

This medication should be stored in a tightly sealed container to prevent air exposure and kept at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the medication's efficacy and allow safe use.

Appearance

An opaque white or nearly white hard capsule containing sustained-release pellets.

Package unit

30 capsules/bottle