Anasto Tablets (Anastrozole)

Adult dose

○ Adults: Administer 1 mg of anastrozole orally once daily. ○ Patients with renal impairment: No dose adjustment is necessary in patients with mild or moderate renal impairment. Do not administer this medicine to patients with severe renal impairment (creatinine clearance 30 mL/min or lower). ○ Patients with hepatic impairment: No dose adjustment is necessary in patients with mild hepatic impairment. Do not administer this medicine to patients with moderate or severe hepatic disease.

Child dose

○ Children: Do not administer to children aged 18 years or younger.

This drug should not be used in premenopausal women as its safety and efficacy have not been established. If menopause status is uncertain, a blood test should be performed for certain verification. Patients with severe liver or kidney impairment have not been studied with this drug, and therefore, it should be avoided. This drug lowers estrogen levels in the body, which can reduce bone density and increase the risk of fractures; hence, patients with osteoporosis or those at risk should have regular bone density tests before and during treatment, and prevention and treatment of osteoporosis may be necessary. There are no studies regarding the co-administration of this drug with specific hormonal agents such as LHRH analogs, and therefore, they should not be used together. Women who are pregnant or may become pregnant, nursing mothers, and patients allergic to this drug or its components should not use this medication. Additionally, patients with a genetic lactase deficiency should also avoid this drug. While taking this medication, common symptoms may include flushing, fatigue, arthralgia, headache, nausea, rash, bone pain, myalgia, vaginal dryness, vaginal bleeding, thinning hair (alopecia), diarrhea and vomiting, drowsiness, carpal tunnel syndrome, sensory disturbances, appetite loss, hypercholesterolemia, trigger finger, erythema multiforme, cutaneous vasculitis, cold symptoms, fever, sore throat, malaise, accidental injury, infection, hypertension, and thrombophlebitis. Rarely, serious skin reactions or allergic reactions may occur; if abnormal symptoms appear, immediate consultation with healthcare providers is necessary. This medication does not significantly affect the ability to drive or operate machinery, but caution should be taken in the presence of fatigue or confusion. Clinical trial results indicate that patients taking this medication may experience increased blood cholesterol levels; therefore, monitoring through blood tests is necessary. In cases of overdose, there are no specific antidotes, and treatment should be symptomatic; if the patient is conscious, vomiting may be induced. Additionally, this drug is not easily eliminated from the body, making regular observation and supportive treatment important. This medication should be kept out of the reach of children and stored in its original container to prevent quality degradation or misuse. Pregnant or nursing mothers should not use this medication, and it is not recommended for children and adolescents under 18 due to established safety and efficacy concerns. Serious side effects such as liver dysfunction, pneumonia, and thrombosis may occur, so if symptoms arise, immediate notification to healthcare providers is required, along with regular liver function tests and symptom monitoring. This drug may have reduced efficacy when used in combination with tamoxifen or estrogen-containing therapies, so they should not be used together.

• Facial flushing
• weakness
• joint pain
• arthritis
• headache
• nausea
• rash
• bone pain
• myalgia
• vaginal dryness

This medication should be stored in a tightly closed container to keep out air and moisture, and it should be kept in a cool place below 30 degrees Celsius to maintain efficacy.

Appearance

White round film-coated tablet

Package unit

28 tablets (14 tablets/PTP x 2)