Combiplex Lipid Central Injection

Adult dosage

The dosage and infusion rate are determined based on the ability to eliminate lipids and glucose metabolism, and the size of the dosage bag is adjusted according to the patient's condition, weight, and nutritional needs. - For patients with normal nutritional status or minor metabolic stress: Amino acids as 0.7-1.0g/Kg (0.10 - 0.15 g nitrogen/kg) per day. - For patients experiencing moderate to severe metabolic stress: Amino acids as 1.0-2.0 g/Kg (0.15 - 0.30 g nitrogen/kg) per day through intravenous drip infusion. General administration of a total of 0.7-1.3 g/Kg (0.10 - 0.20 g nitrogen/kg) as amino acids is given by central venous drip infusion, which corresponds to 19-38 mL/kg of this medication per day.

This medication must be used under the direction of a physician. If anaphylactic reactions such as fever, chills, rash, and difficulty breathing occur, administration must be stopped immediately. When used with ceftriaxone, precipitates may form, so the same infusion apparatus must not be used simultaneously. Caution is needed in premature or low-birth-weight infants due to their low lipid elimination ability, which can be risky. Patients with allergies to egg, soybean protein, severe liver dysfunction, hyperlipidemia, or blood clotting disorders should not receive this medication. It should be administered cautiously in patients with renal failure, pancreatitis, liver dysfunction, or any issues with lipid metabolism. During administration, monitoring for abnormal reactions such as fever, chills, nausea, increased liver enzyme levels, and thrombophlebitis is necessary. Serious adverse effects such as lipid overload syndrome may occur, so avoiding overdose is crucial. In the initial phase of administration, closely monitor the patient's condition, and start administering once the electrolyte imbalance is corrected. Aseptic techniques are critical for infection prevention during central venous administration. After administration, blood triglyceride levels must be measured periodically to confirm lipid elimination capability. Regular checks of blood sugar, electrolytes, liver and kidney function, and other parameters must be conducted during the administration. Administration should not be conducted simultaneously with blood, and potential interactions with other medications must be considered. Caution is advised for pregnant or breastfeeding women, and for the elderly, the administration rate should be slowed down and the dose adjusted. Accurate clinical test results can only be obtained after 5-6 hours post-administration, so this must be noted. In the case of overdose, symptoms such as nausea, vomiting, and electrolyte imbalance may appear, and administration must be stopped immediately or slowed down; blood dialysis may be necessary as needed. Do not use if the packaging is damaged, the solution is cloudy or separated, and dispose of any leftover solution after administration. This medication should be stored at temperatures between 0-25°C, and freezing is prohibited.

Serious side effects

Anaphylactic reactions (hives, skin rash), difficulty breathing, high fever, coma.

Mild side effects

Elevated body temperature, chills, nausea/vomiting, transient increases in liver enzymes, thrombophlebitis when injected peripherally, high/low blood pressure, hemolysis, reticulocytosis, abdominal pain, headache, fatigue, penile erection, hyperlipidemia, fat deposition, liver enlargement, splenomegaly, anemia, leukopenia, thrombocytopenia, blood coagulation disorders.

This medication must be stored in a sealed container to prevent air ingress, and the temperature must be kept below 25 degrees Celsius. Care must be taken to prevent the medication from freezing.

Appearance

Composed of internal compartments divided into three chambers and an external package. There is an oxygen absorbent pouch between the internal compartments and the external packaging. The compartments of the internal bag each contain:

Package unit

1540ml (Solution A: 790, Solution B: 450, Solution C: 300), 2053ml (Solution A: 1053, Solution B: 600, Solution C: 400)