Ceftriaxone Sodium Hydrate Injection 2 grams

Adult administration

Adults and children over 12 years: administer 1-2 g (potency) of ceftriaxone once daily via intravenous or intramuscular injection. For infections caused by severe disease or moderate-sensitivity pathogens, the dose can be increased to 4 g (potency) once daily. Elderly: can follow the adult dosage and schedule without modification. Gonorrhea: a single intramuscular injection of 250 mg (potency) is recommended for treating penicillin-sensitive and resistant strains of gonorrhea.

Child administration

Neonates (up to 14 days old): administer 20-50 mg (potency) per kg of body weight once daily, not exceeding 50 mg (potency) per kg. Infants and children (15 days to 12 years): body weight.

This medication should not be mixed or administered simultaneously with solutions or drugs containing calcium. It should not be administered to newborns, especially those under 28 days old, as it can be dangerous when used with calcium-containing solutions. Patients with allergies to this medication, or those with hypersensitivity to cephalosporins or penicillin antibiotics should not use it. Additionally, it should not be administered to patients with allergies to certain local anesthetics, premature infants, jaundiced newborns, or newborns with problems in binding bilirubin in the blood. When using this medication, caution should be taken in patients with a history of drug allergies or those with a constitution prone to allergic symptoms such as asthma or skin rashes. For patients with poor renal function, elderly patients, or those in poor physical condition, dosage adjustment or interval modification may be necessary. Common side effects that may arise while administering this medication include changes in blood cell counts, diarrhea, skin rashes, and liver function abnormalities. Rarely, severe allergic reactions, renal function abnormalities, and central nervous system adverse symptoms may occur. If any abnormal symptoms appear, consult healthcare personnel immediately. During administration, it is essential to conduct regular checks of liver and kidney function, blood tests, etc., to early identify and manage adverse reactions. Furthermore, this medication may interact with other drugs, so be sure to inform healthcare personnel about any medications being taken concurrently. Women who are pregnant or breastfeeding should carefully consider the benefits and risks of using this medication, and it is particularly safe not to use it in newborns or premature infants. This medication may cause side effects such as dizziness when driving or operating machinery, so caution is advised. In case of overdose, there is no specific antidote, and symptomatic treatment is required. Lastly, this medication should be used as soon as possible after preparation, and appropriate temperature and conditions must be maintained during storage.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, anaphylaxis and anaphylactic-like reactions, severe allergic reactions, severe skin adverse reactions (such as erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), jaundice, acute renal failure, sudden and severe headache, encephalopathy, seizures, consciousness confusion, vision disturbances, paralysis, severe swelling or urinary abnormalities, renal impairment, thrombocytopenia, severe hemolysis due to hematological changes.

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headache
• dizziness
• bronchospasm
• nausea

This medication should be stored in a sealed container to prevent air or moisture ingress, preferably at room temperature between 1 to 30 degrees Celsius. This is the recommended storage method to maintain the efficacy of the medication and prevent deterioration.

Appearance

A white to pale yellow crystalline powder contained in a colorless transparent vial.

Package unit

1 vial, 10 vials