Azis Syrup (Azithromycin Hydrate)

Adult dose

Administer once daily; it may be taken without regard to meals. Adults 1) Sexually transmitted infection caused by Chlamydia trachomatis associated with trachoma: Administer 25 mL [azithromycin 1 g (potency)] as a single dose 2) Other indications - 3-day regimen: Administer 12.5 mL [azithromycin 500 mg (potency)] once daily for 3 days [total dose: azithromycin 1.5 g (potency)] - 5-day regimen: Administer 12.5 mL [azithromycin 500 mg (potency)] once on the first day; from the second day, administer 6.25 mL [azithromycin 250 mg (potency)] once daily for 4 days [total dose: azithromycin 1.5 g (potency)] Elderly patients Administer the same dosage and administration as for adults

Child dose

Administer azithromycin 10 mg (potency) per kg of body weight once daily for 3 days, or administer 10 mg (potency) per kg of body weight once on the first day, followed by 5 mg (potency) per kg of body weight once daily for 4 days from the second day. In addition to the two regimens above, the recommended dose for treating pediatric patients with acute otitis media may be a single dose of 30 mg (potency) per kg of body weight. For this 1-day regimen, take the medicine 1 hour before a meal or 2 hours after a meal. 15~25 Kg: 1-day regimen (for acute otitis media) 15 mL [azithromycin 600 mg (potency)] as a single dose; 3-day regimen 5 mL [azithromycin 200 mg (potency)] once daily for 3 days; 5-day regimen 5 mL [azithromycin 200mg (potency)] once on the first day, followed from the second day by 2.5 mL [azithromycin 100 mg (potency)] once daily for 4 days 26~35 Kg: 1-day regimen (for acute otitis media) 22.5 mL [azithromycin 900 mg (potency)] as a single dose; 3-day regimen 7.5 mL [azithromycin 300 mg (potency)] once daily for 3 days; 5-day regimen 7.5 mL [azithromycin 300 mg (potency)] once on the first day, followed from the second day by 3.75 mL [azithromycin 150 mg (potency)] once daily for 4 days 36~45 Kg: 1-day regimen (for acute otitis media) 30 mL [azithromycin 1.2 g (potency)] as a single dose; 3-day regimen 10 mL [azithromycin 400 mg (potency)] once daily for 3 days; 5-day regimen 10 mL [azithromycin 400 mg (potency)] once on the first day, followed from the second day by 5 mL [azithromycin 200 mg (potency)] once daily for 4 days 45 Kg or more: 1-day regimen (for acute otitis media) 37.5 mL [azithromycin 1.5 g (potency)] as a single dose; 3-day regimen, same as the adult dose; 5-day regimen, same as the adult dose

This medication is a macrolide antibiotic, and while allergic reactions are rare, they can be severe. If symptoms such as angioedema or anaphylaxis occur, administration should be stopped immediately. If diarrhea or abdominal pain occurs, it is important to monitor closely, especially considering the possibility of diarrhea caused by the bacterium Clostridium difficile. This medication should not be used in patients with specific allergies, those taking ergot alkaloids, or patients with fructose intolerance. Patients with very poor kidney function or severe liver dysfunction should use this medication cautiously, and treatment should be stopped immediately if liver dysfunction symptoms appear. Diabetic patients should carefully manage blood sugar levels due to the lactose component in this medication. Various side effects such as nausea, vomiting, diarrhea, abdominal discomfort, abnormal liver function, skin rashes, etc., may occur while taking this medication. If symptoms persist or worsen, consultation with medical personnel is necessary. In particular, symptoms such as hearing impairment, dizziness, and arrhythmias have been reported, so caution is required when taking higher doses or for prolonged periods. Like other antibiotics, this medication poses a risk of additional infections due to resistant bacteria, so observations for unusual symptoms are necessary. Patients with heart disease, electrolyte imbalances, or those taking specific medications should consult medical personnel before administration, as there is a risk of cardiac rhythm disturbances. During pregnancy, this medication should only be used when absolutely necessary, and during breastfeeding, it should be used only after consulting a doctor as the drug may pass into breast milk. Elderly patients should be monitored carefully due to the increased risk of arrhythmias. In case of overdose, general treatment should be pursued, and the suspension should be prepared and stored according to instructions. When administering to children, the correct dose should be calculated based on weight, and the medication should be stored out of reach of children.

Angioedema, anaphylaxis, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reactions accompanied by eosinophilia and systemic symptoms, diarrhea, nausea, vomiting, loose stool, abdominal discomfort, abdominal distension, liver dysfunction, rash, vascular edema, candidiasis, vaginitis, thrombocytopenia, leukopenia, granulocytopenia, shock, symptoms of anaphylaxis, loss of appetite, aggressive reactions, neurosensitivity, agitation, anxiety, dizziness, convulsions, headache, hyperactivity, sensory abnormalities, drowsiness, sensory loss, fainting, taste/olfactory disturbances and loss, hearing loss, tinnitus, auditory dysfunction, palpitations, ventricular tachycardia, arrhythmia, QT interval prolongation, Torsades de pointes, hypotension, dyspepsia, constipation, pseudomembranous colitis, pancreatitis, pyloric stenosis, tongue discoloration, hepatitis, jaundice, cholestatic jaundice, liver necrosis, liver failure, itching, photosensitivity reactions, edema, urticaria, angioedema, erythema multiforme, arthralgia, rhabdomyolysis, myalgia, fatigue, lethargy, interstitial nephritis, acute kidney failure, weakness, tiredness, malaise, interstitial pneumonia, eosinophilic pneumonia, fever, cough, shortness of breath, abnormal chest X-ray findings

This medication can be sensitive to air and moisture; therefore, it should be stored in a tightly sealed container to prevent contact with the outside. Additionally, it is best to store it at room temperature that is neither too hot nor too cold.

Appearance

White to pale pink powder

Package unit

15 milliliters/bottle