Asmacin Dry Syrup (Azithromycin Hydrate)

Adult dose

Take once daily. ○ Adults 1) Sexually transmitted infection caused by Chlamydia trachomatis associated with trachoma: Administer 25mL[azithromycin 1g (potency)] as a single dose 2) Other indications - 3-day regimen: Administer 12.5mL[azithromycin 500mg (potency)] once daily for 3 days [total dose: azithromycin 1.5g (potency)] - 5-day regimen: Administer 12.5mL[azithromycin 500mg (potency)] once on the first day; from the second day, administer 6.25mL[azithromycin 250mg (potency)] once daily for 4 days [total dose: azithromycin 1.5g (potency)] ○ Elderly patients Administer the same dosage and administration as for adults

Child dose

○ Children Administer azithromycin 10mg (potency) per kg of body weight once daily for 3 days, or administer 10mg (potency) per kg of body weight once on the first day, followed by 5mg (potency) per kg of body weight once daily for 4 days from the second day. In addition to the two regimens above, the recommended dose for treating pediatric patients with acute otitis media may be a single dose of 30mg (potency) per kg of body weight. For this 1-day regimen, take the medicine 1 hour before a meal or 2 hours after a meal. 15～25Kg: 1-day regimen (for acute otitis media) 15mL [azithromycin 600mg (potency)] as a single dose; 3-day regimen 5mL [azithromycin 200mg (potency)] once daily for 3 days; 5-day regimen 5mL [azithromycin 200mg (potency)] once on the first day, followed from the second day by 2.5mL[azithromycin 100mg (potency)] once daily for 4 days 26～35Kg: 1-day regimen (for acute otitis media) 22.5mL [azithromycin 900mg (potency)] as a single dose; 3-day regimen 7.5mL [azithromycin 300mg (potency)] once daily for 3 days; 5-day regimen 7.5mL [azithromycin 300mg (potency)] once on the first day, followed from the second day by 3.75mL[azithromycin 150mg (potency)] once daily for 4 days 36～45Kg: 1-day regimen (for acute otitis media) 30mL [azithromycin 1.2g (potency)] as a single dose; 3-day regimen 10mL [azithromycin 400mg (potency)] once daily for 3 days; 5-day regimen 10mL [azithromycin 400mg (potency)] once on the first day, followed from the second day by 5mL [azithromycin 200mg (potency)] once daily for 4 days 45Kg or more: 1-day regimen (for acute otitis media) 37.5mL [azithromycin 1.5g (potency)] as a single dose; 3-day regimen, same as the adult dose; 5-day regimen, same as the adult dose

This drug is a macrolide antibiotic and can rarely cause severe allergic reactions. If acute allergic symptoms like angioedema or anaphylaxis occur, discontinue administration immediately and seek appropriate treatment. This drug can alter gut flora and may cause diarrhea or colitis due to Clostridium difficile; therefore, consult a physician if diarrhea occurs. If diarrhea develops, it may be necessary to stop using this medication. This medication should not be administered to patients with certain hypersensitivities, individuals with genetic disorders of carbohydrate metabolism, or patients on certain medications. It is especially contraindicated for patients taking ergot alkaloids or those with fructose intolerance. Caution is advised when administering to patients with severely impaired kidney function, severely impaired liver function, or diabetes; discontinue administration immediately if symptoms of liver dysfunction occur. Generally, this medication has good tolerability, but various side effects such as nausea, vomiting, diarrhea, liver dysfunction, skin rashes have been reported. Rarely, hearing loss, cardiac arrhythmias, muscle damage, hepatitis, and severe skin reactions may occur; notify a physician immediately if any unusual symptoms appear. Like other antibiotics, this drug can lead to resistant strains of bacteria or fungal infections, necessitating careful monitoring of infection symptoms. It may affect heart rhythm, so a careful evaluation is necessary before administration to patients with heart conditions or electrolyte abnormalities and those at high risk for QT interval prolongation. Patients with myasthenia gravis should be cautious as symptoms may worsen during treatment with this medication. There is insufficient data on the safety of this drug during pregnancy, so it should be used only when the therapeutic benefits outweigh the risks, and caution should be taken during breastfeeding as it can be excreted in breast milk. Elderly patients may have an increased risk of arrhythmias; therefore, it should be administered with caution. In case of overdose, symptomatic and supportive therapy is required, and the prescribed dose and method should be strictly followed. Finally, keep out of reach of children and store in its original container to prevent misuse or deterioration of quality.

angioedema, anaphylaxis, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reactions with eosinophilia and systemic symptoms, diarrhea, hearing loss, deafness, tinnitus, auditory disorders, nausea, vomiting, diarrhea, loose stools, abdominal discomfort, abdominal distension, abnormal liver function, rash, vascular edema, moniliasis, vaginitis, thrombocytopenia, leukopenia, agranulocytosis, shock, anaphylactic symptoms, anorexia, aggressive reactions, neuropathic symptoms, agitation, anxiety, dizziness, convulsions, headache, hyperactivity, sensory disturbances, drowsiness, sensory loss, fainting, dysgeusia, hyposmia, ageusia, anosmia, palpitations, ventricular tachycardia, arrhythmia, QT prolongation, Torsades de pointes, hypotension, dyspepsia, constipation, membrane enterocolitis, pancreatitis, pyloric stenosis, tongue discoloration, hepatitis, jaundice, cholestatic jaundice, liver necrosis, liver failure, pruritus, photosensitivity reactions, edema, urticaria, angioedema, erythema multiforme, arthralgia, rhabdomyolysis, myalgia, feelings of exhaustion, interstitial nephritis, acute renal failure, weakness, fatigue, malaise, fever, cough, shortness of breath, abnormal chest X-ray, interstitial pneumonia, eosinophilic pneumonia, infantile hypertrophic pyloric stenosis

This medication may be sensitive to air or moisture, so it is important to store it in a tightly closed container. Maintain the storage temperature between 1 degree and 30 degrees Celsius and avoid extremely hot or cold places.

Appearance

White to pale yellow powder

Package unit

15 milliliters/bottle