Progynova 28 Tablets 2 mg (Estradiol Valerate)

Key information summary

Efficacy & effects

This medication is used as hormone replacement therapy to alleviate menopausal symptoms in women undergoing menopause. It is also effective in preventing osteoporosis in women at high risk of fractures. If the woman has a uterus, progestogen should be taken simultaneously for 12 days each month. This medication helps manage women's healthy menopause and improves bone health.

Dosage

As estradiol valerate, administer 1 mg or 2 mg orally after meals daily. Continue treatment and take the next new pack immediately without stopping. Adjust the dose appropriately according to the treatment outcome. Swallow the tablet whole with a suitable beverage, and aim to take it at the same time every day.

Precautions

This medication may increase the risk of endometrial cancer in women with a uterus, so additional hormone therapy should be done as instructed by a doctor. There is a risk of serious vascular problems such as thrombosis occurring during the use of this medication, so patients at risk for thrombosis should consult their doctor thoroughly before taking it and discontinue immediately if symptoms arise. If severe headaches or migraines occur or worsen, treatment should be discontinued and a doctor consulted. If there are sudden visual disturbances or symptoms of thrombosis, the use of this drug must be stopped immediately. If symptoms of liver dysfunction, jaundice, pregnancy, or elevated blood pressure appear, this medication must be discontinued, and it should never be taken during pregnancy. This medication is not administered to patients with estrogen-dependent tumors or a history of thrombosis, severe liver or kidney disease, pregnant women, and nursing mothers. Patients with specific diseases such as smooth muscle tumors, hypertension, diabetes, migraines, liver diseases, or with a past medical history should use this medication cautiously and require regular examinations and monitoring. While taking this medication, the risk of hormone-related cancers such as breast cancer, ovarian cancer, and endometrial cancer may increase, so regular check-ups are important. This medication may interact with other drugs, so if any other medications are being taken, it is essential to inform the doctor or pharmacist. Pregnant or potentially pregnant women and nursing mothers should not take this medication, and if pregnancy is confirmed during treatment, it must be discontinued immediately. This drug is not used in children or adolescents due to the risk of early closure of the epiphysis or premature sexual development. In case of overdose, symptoms such as anxiety, nausea, and abdominal distension may occur, but generally, dose adjustment will improve the symptoms. This medication should be stored out of reach of children and kept in its original container to prevent deterioration or misuse.

Side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in the oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), profound lethargy throughout the body, sudden and very severe headache, lightning headache, seizures, confusion of consciousness, visual disturbances, paralysis,

Alternatives / Same-ingredient medications

• Estradiol depot injection 10mg (estradiol valerate)

  Same ingredient
• 

  Progynova 28 Tablets 1 mg (Estradiol Valerate)

  Same ingredient

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