Zeldox Capsule 20mg (Ziprasidone Hydrochloride Monohydrate)

Adult dose

Take this medication with food. Swallow it whole without chewing or crushing it, or opening the capsule. 1. Schizophrenia The recommended dose for acute treatment is 40 mg per dose twice daily with food. Thereafter, the daily dose may be adjusted, based on the individual's clinical status, up to a maximum of 80 mg per dose twice daily. If dose adjustment is needed based on signs of illness, adjustments should generally be made at intervals of at least 2 days. The maximum recommended dose (80 mg twice daily) may be reached as early as the third day of treatment. For maintenance treatment, patients should take the minimum effective dose; 20 mg per dose twice daily is sufficient for many patients. 2. Treatment of bipolar I disorder Acute treatment of manic or mixed episodes associated with bipolar I disorder Initial treatment: The initial daily dose is 40 mg per dose twice daily with food. The dose may then be increased to 60 mg or 80 mg per dose twice daily on day 2, and thereafter adjusted within a range of 40 ~ 80 mg per dose twice daily, according to tolerability and efficacy. In clinical trials using flexible dosing, the mean daily dose was approximately 120 mg. Maintenance treatment: There are no data from controlled clinical trials to guide physicians in long-term treatment of patients whose symptoms improved during acute treatment of mania with ziprasidone alone. Adjunctive therapy with a mood stabilizer (lithium or valproate) for maintenance treatment of bipolar I disorder Continue treatment with 40-80mg per dose twice daily with food, using the same dose at which the patient was stabilized during initial treatment. No dose adjustment is required in patients aged 65 years or older. No dose adjustment is required in patients with renal impairment. In patients with mild to moderate hepatic impairment due to cirrhosis (Child-Pugh A or B), serum drug concentrations after oral administration increased by 30% and the terminal half-life was approximately 2 hours longer compared with patients with normal hepatic function. Ziprasidone should be used with caution in patients with hepatic impairment. No dose adjustment is required for smokers.

Child dose

The safety and efficacy of ziprasidone in pediatric patients under 18 years of age have not been established.

This medication can affect the electrical activity of the heart and may cause abnormalities in heart rhythm; therefore, patients with a history of heart disease or QT interval prolongation should be particularly cautious. During the use of this medication, it is important to regularly check potassium and magnesium levels in the blood to prevent electrolyte imbalances. A serious side effect known as Neuroleptic Malignant Syndrome may occur, so if symptoms such as high fever, muscle rigidity, or altered consciousness develop, medical personnel should be informed immediately. If you experience severe skin rashes or allergic reactions, discontinue the medication and seek medical attention immediately. Long-term use may cause abnormal movements; if you feel any abnormality in body movement, consult a physician. This medication may cause dizziness or drowsiness, so caution is advised when driving or operating machinery. Elderly patients or those at risk for cerebrovascular disease should take special care when using this medication. There is a risk of thrombosis, so consult your doctor if there are any risk factors for thrombosis. Pregnant or breastfeeding women should consult with a physician before taking this medication, and it is advisable to avoid use during pregnancy whenever possible. This medication may interact with other drugs, so it is essential to inform medical personnel about any other medications being taken. Overdose may cause serious side effects, so prescribed dosages should be strictly followed in accordance with medical advice. The safety of this medication in children has not been established, so it should not be used by individuals under 18 years of age. Store the medication in a cool room away from direct light and out of reach of children.

QTc interval prolongation, torsade de pointes, sudden death, high fever, muscle rigidity, altered mental state, irregular pulse and blood pressure, tachycardia, cardiac arrhythmia, sweating, increased creatine phosphokinase, rhabdomyolysis, acute renal failure, drug reactions (rash, exfoliative dermatitis, eosinophilia, fever, lymphadenopathy, hepatitis, nephritis, pneumonia, myocarditis, pericarditis), Stevens-Johnson syndrome, tardive dyskinesia, drowsiness, orthostatic hypotension, motor and sensory instability, headache, weakness, constipation, thirst, increased salivation, nausea, vomiting, weight loss, agitation, akathisia, anxiety, dizziness, movement disorder, dystonia, extrapyramidal syndrome, hypertonia, insomnia, tremor, laboratory test abnormalities, pain, allergic reactions, fever, suicidal ideation, hypotension, tachycardia, bradycardia, congestive heart failure, migraine, dyspepsia, bloating, tongue swelling, gastritis, fatty liver, eosinophilia, increased ALT, dryness, increased alkaline phosphatase, dehydration, increased LDH, arthropathy, leg cramps, arthralgia, myalgia, myasthenia, chorea, akathisia, depression, dysphonia, generalized tonic-clonic seizure, hallucinations, hostility, motor function decrease, muscle weakness, ocular motor seizure, sensory distortion, speech impairment, dream disturbance, abnormal gait, akinesia, ataxia, confusion, neuropathy, paralysis, stupor, affective flattening, rhinitis, maculopapular rash, rash, urticaria, psoriasis, skin disorders, visual disturbances, amblyopia, conjunctivitis, dry eyes, optic neuritis, incontinence, dysuria, gynecomastia, erectile dysfunction, suicide attempt, irregular pulsation, bruising, accidental injury, hypertension, diarrhea, dysphagia, myalgia, sensory loss, speech impairment, pharyngitis, dyspnea, fungal dermatitis, enuresis, priapism, nocturia, frequency of urination, leukopenia, palpitations, drug overdose, memory impairment, sleep disorders, excessive sedation, hallucination, open chest wound.

This medication should be stored in a tightly closed container to protect it from air and moisture. It is best to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

A capsule with a blue upper part and a white lower part containing a white to light gray powder.

Package unit

30 capsules (10 capsules/blister x 3)