Clarithromycin 500 mg Tablets

Adult dose

○ Adults : The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment period is 7～14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to such patients for more than 14 days. ○ Mycobacterial infections : Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers : Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years of age and older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, patients who are allergic to this drug's ingredients or similar antibiotics, those with a history of heart arrhythmias, patients with severe liver or kidney dysfunction, and women who are pregnant or breastfeeding should not take this drug. Moreover, serious side effects may occur when this drug is taken with certain other medications, so if currently taking any medications, it is essential to consult a doctor or pharmacist. Caution is especially warranted when combined with medications affecting the heart, certain antibiotics, or statins. While taking this medication, rare side effects such as allergic reactions, gastrointestinal issues, liver dysfunction, kidney problems, skin rashes, neurological issues may occur, and if any unusual symptoms arise, immediate medical attention should be sought. Long-term use or overdose of this drug may lead to hearing problems or muscle-related side effects, so it is crucial to strictly adhere to the prescribed dosage and duration. Particularly in elderly patients or those with impaired liver or kidney function, dosage adjustments may be required, so they should follow medical advice. When using this drug, it is important to administer it for the minimum period after susceptibility testing to prevent the emergence of resistant bacteria. Additionally, this medication may cause decreased concentration or dizziness while driving or operating machinery, so caution is necessary. Finally, women who are pregnant or breastfeeding should avoid taking this medication, and if unavoidable, breastfeeding should be discontinued.

Shock, anaphylactic symptoms, breathlessness, convulsions, redness, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosa erosion, upper abdominal pain, thirst, tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, discoloration of stools, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, ageusia, anosmia, anxiety, insomnia, nightmares, tinnitus, confusion, impaired orientation, hallucination, psychosis, depersonalization, tremors, paresthesia, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, venous thrombophlebitis at injection site, pain at injection site, inflammation at injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, cardiac arrest, atrial fibrillation, prolonged QT on ECG, ectopic beats, palpitations, ventricular fibrillation, vasodilation

This drug is light-sensitive and should be stored in a container that protects it from light. Furthermore, it is best to keep the medication at room temperature between 15 and 30 degrees Celsius, avoiding extremes of cold or heat.

Appearance

Yellow oval film-coated tablets

Package unit

Domestic use: 28 tablets/bottle For export: 30 tablets (10 tablets/PTP x 3)