Seprotil Tablet (Sephuroxime Acetil)

Adult dose

For optimal absorption, take after meals. Adults and children aged 12 years and older — Most infections: 250mg twice daily. Adults and children aged 12 years and older — Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by organisms with reduced susceptibility: 500mg twice daily. Adults and children aged 12 years and older — Urinary tract infections: 250mg twice daily. Adults and children aged 12 years and older — Uncomplicated gonorrhea: 1g as a single dose. Adults and children aged 12 years and older — Lyme disease: 500mg twice daily for 14 days (10~21 days). For treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this medicine should be administered for 7~10 days. Patients with renal impairment: Cefuroxime is eliminated primarily by the kidneys. To compensate for delayed elimination in patients with significant renal impairment, it is recommended that the cefuroxime dosage be reduced as follows. Creatinine clearance ≥ 30 mL/min/1.73m2, T1/2 (hours) 1.4 - 2.4: No dosage adjustment required (standard dose: 125mg-500mg twice daily) Creatinine clearance 10 - 29 mL/min/1.73m2, T1/2 (hours) 4.6: Administer a standard single dose every 24 hours Creatinine clearance < 10 mL/min/1.73m2, T1/2 (hours) 16.8: Administer a standard single dose every 48 hours Patients on hemodialysis, T1/2 (hours) 2 - 4: Administer an additional standard single dose at the end of each dialysis session

Child dose

Infants and children under 12 years — Most infections: 125mg twice daily. Children aged 2 years and older — Otitis media and severe infections: 250mg twice daily. Infants and children under 12 years — Lyme disease: 250mg twice daily for 14 days (10~21 days). Infants under 3 months: There is insufficient experience with use.

This medication is a cephalosporin antibiotic and should not be administered to patients with hypersensitivity to cephalosporins. It should be used cautiously in patients with a history of allergy to penicillins or other beta-lactam antibiotics, or those with allergic constitution. Care is needed for patients with severe renal impairment, those unable to take oral medication, the elderly, and patients in poor general condition, and careful observation for signs of vitamin K deficiency is required. While taking this medication, there may occur rare but severe skin reactions or allergic reactions, so if symptoms such as skin rash, urticaria, fever, or difficulty breathing arise, administration should be stopped immediately and a healthcare professional consulted. Common side effects such as headache, dizziness, gastrointestinal disturbance, diarrhea, and nausea may occur, and particularly in elderly patients or those with severe infections, changes in mental status may be observed. During antibiotic use, overgrowth of Candida species may occur, and serious gastrointestinal disorders such as pseudomembranous colitis can arise, so if diarrhea or abdominal pain persists, healthcare personnel should be informed immediately. This medication may cause dizziness when driving or operating machinery, so caution is necessary. There may be interactions with other medications; therefore, when taking diuretics, aminoglycoside antibiotics, probenecid, or antacids, one should inform the doctor or pharmacist. Women who are pregnant or breastfeeding should use this medication carefully, considering both the need for treatment and the risks, as its safety has not been established. The safety for infants under three months has not been confirmed, and for children, using a dry syrup formulation is preferable to crushing tablets. Elderly patients may experience side effects more frequently due to decreased physiological function; thus, dosage and administration intervals should be adjusted, and their condition should be monitored closely. This medication may affect some clinical test results, so patients should inform healthcare personnel of its use during tests. In the case of overdose, severe side effects such as convulsions may occur, and drug concentrations can be lowered through hemodialysis or peritoneal dialysis. Lastly, this medication should be stored out of reach of children and in its original container; transferring it to another container may lead to misuse or degradation of quality.

• Candidiasis overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• erythrocytopenia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This medication should be stored in a tightly closed container to prevent air and moisture from entering. It is also advisable to store the medication at room temperature between 1°C and 30°C. This helps maintain the effectiveness of the drug and prevent degradation.

Appearance

White rectangular film-coated tablets

Package unit

50 tablets (10 tablets/PTP × 5)