Cremar Tablet 500 mg (Clarithromycin)

Adult dose

○ Adults : The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections : Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers : Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: same as adults; children under 12 years of age should use clarithromycin dry syrup.

This medication should not be administered to certain patients. For example, patients who are allergic to any ingredient of this drug or similar antibiotics, those with severe heart rhythm irregularities or significant liver and kidney dysfunction, may face risks when taking this medication. Furthermore, it is not safe for pregnant or breastfeeding women to use this drug. There may be side effects such as cardiac arrhythmias or increased drug concentration when taken with some medications, so if you are currently on any medication, you must consult your doctor or pharmacist. Patients with poor liver or kidney function, elderly individuals, and those with heart diseases should take special care when using this medication, and may require dosage adjustments by a doctor. During the course of taking this drug, serious allergic reactions or skin rashes, liver function abnormalities, gastrointestinal issues, neurological symptoms may occur rarely; thus, if abnormal symptoms arise, inform a healthcare professional immediately and seek treatment. Additionally, this medication may affect the gut microbiome, possibly resulting in diarrhea or gastroenteritis, and long-term use may lead to antibiotic resistance; therefore, it is essential to take it only for the prescribed duration as per a doctor's instruction. This drug can interact with other medications, altering their effectiveness or increasing the risk of side effects, so if you are taking another drug, you should consult a specialist. Pregnant or breastfeeding women should avoid taking this drug, and particularly women of childbearing potential should consult a doctor before taking it. Children and the elderly require special attention regarding the use of this drug, especially since the safety and efficacy in children have not been sufficiently studied; therefore, it should be administered based on a doctor's judgment. In the case of overdose, gastrointestinal disturbances or changes in mental state may occur, so care should be taken not to exceed the recommended dose, and if an overdose is suspected, immediate emergency treatment should be sought. This medication should not be refrigerated during storage; it is best to keep it in a dark place, away from direct sunlight, at room temperature.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, mild skin erythema, angioedema, joint swelling, drug rash, abdominal distention, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral lesions, upper abdominal pain, polydipsia, transient tooth discoloration, pancreatitis, elevated amylase, dysgeusia, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, chest X-ray abnormalities, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, anosmia, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, impaired liver function, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, increased total bilirubin, loss of appetite, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, myalgia, weakness, elevated CPK, increased myoglobin in blood and urine, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de Pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle spasms, musculoskeletal rigidity, myopathy, elevated blood urea nitrogen, nephritis, venous thrombophlebitis at injection site, pain at injection site, inflammation at injection site, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio (INR), prolonged prothrombin time, urinary discoloration, cardiac arrest, atrial fibrillation, prolonged QT interval on ECG, premature contractions, palpitations, vasodilation, asthma, nosebleeds, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, teeth discoloration, rash, hyperhidrosis, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura

This medication is sensitive to light, so it should be stored in a container that does not allow light to pass through. Additionally, it is important to maintain a temperature between 15 and 30 degrees Celsius, avoiding very hot or cold environments.

Appearance

Yellow rectangular film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle