Levafloxacin 500 mg Tablet (Levafloxacin Hydrate)

Adult dose

For adults, the usual recommended dosage is 250–750 mg orally once daily. In patients with normal renal function, 750 mg is administered at 24-hour intervals for 10–14 days for complicated skin and soft tissue infections. For community-acquired pneumonia, 500 mg is administered at 24-hour intervals for 7 days. The treatment duration for acute bacterial exacerbation of chronic bronchitis is 7 days, acute sinusitis is 10–14 days, and chronic bacterial prostatitis is 28 days.

This drug is a fluoroquinolone antibiotic and may cause serious adverse effects such as tendon disorders like tendonitis or tendon rupture, peripheral neuropathy, central nervous system effects, and exacerbation of myasthenia gravis. Therefore, if such symptoms occur, it is essential to stop taking the medication immediately and consult a doctor. Additionally, this drug should not be used in patients with myasthenia gravis. It is safe to administer this drug only for specific bacterial infections when alternative treatment options are unavailable. Caution is required, especially in elderly individuals, patients with impaired renal function, and those taking corticosteroids, as the risk of tendon rupture may increase. Pregnant or nursing women, adolescents under 18 years of age, patients with epilepsy, and individuals allergic to this drug or similar medications should avoid taking it. This drug should be used cautiously in patients with reduced renal function or central nervous system disorders, and special care is needed when used in conjunction with certain anti-inflammatory agents or antidiabetic medications. During treatment, there may be symptoms such as allergic reactions, skin rashes, severe diarrhea, liver or kidney function abnormalities, blood abnormalities, and central nervous system symptoms, so any abnormal symptoms should be reported to a doctor immediately. Furthermore, this drug may increase sensitivity to sunlight, so strong sunlight or exposure to artificial ultraviolet light should be avoided, and caution should be taken when driving or operating machinery if dizziness or drowsiness occurs. It is advisable not to take certain antacids, iron supplements, or calcium supplements simultaneously with this drug, and careful monitoring is required when taken concurrently with anticoagulants like warfarin or theophylline. In cases of overdose, central nervous system symptoms and cardiac side effects may present, and immediate emergency care should be sought as this drug is not removed by hemodialysis. While taking this drug, regular check-ups and examinations with a doctor are necessary, and any abnormal symptoms should be reported immediately.

Serious side effects

• Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions
• Severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, severe skin adverse reactions
• Shortness of breath or difficulty breathing, asthma attacks, breathing difficulties accompanied by cough + fever
• Jaundice (yellowing of the skin or eyes), extreme lethargy, liver abnormalities (jaundice)
• Sudden and severe headache,

Mild side effects

• Nausea
• diarrhea
• vaginitis
• insomnia
• abdominal pain
• bloating
• itching
• dizziness
• rash
• dyspepsia

This drug should be stored in a tightly sealed container to protect it from air and moisture. It is best stored at room temperature, between 1 to 30 degrees Celsius.

Appearance

[For domestic use]: Peach-colored oblong film-coated tablet [For export]: Pink oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 30 tablets/box [(10 tablets/PTP) × 3]