Clarithromycin 500 mg Tablets

Adult dose

○ Adults : The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily; for severe infections, administer 250mg (potency) per dose twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections : Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcer : For 14 days, administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. Children under 12 years: Use clarithromycin dry syrup.

This medication should not be used in patients with a known allergy to any components or with hypersensitivity to macrolide antibiotics. It should be avoided in patients with certain heart conditions or severely impaired liver and kidney function, and care must be taken when taken with specific drugs due to a risk of serious side effects such as cardiac arrhythmias. Pregnant or breastfeeding women should not use this medication, and use in children may be restricted based on age. This medicine can cause allergic reactions or serious side effects, so if symptoms such as rash, difficulty breathing, itching, abdominal pain, diarrhea, changes in hearing, etc., occur, immediate consultation with healthcare professionals is necessary. Patients with compromised liver and kidney function may require dose adjustments, and regular liver function tests and blood tests should be performed during treatment to detect adverse reactions early. There are many drug interactions with this medication; therefore, if the patient is taking any medications, they should inform their doctor or pharmacist, especially when combined with heart disease treatments, anticoagulants, certain antibiotics, and antiviral drugs. Prolonged or high-dose use can result in side effects such as tinnitus, hearing loss, and muscle pain, so if symptoms appear, treatment should be discontinued and a doctor consulted. This medication must be taken strictly as prescribed in duration and dosage to prevent the emergence of antibiotic-resistant bacteria, and should not be stopped arbitrarily even if symptoms improve. Caution should be taken while driving or operating machinery as dizziness or confusion may occur. An overdose can lead to gastrointestinal disturbances or neurological symptoms, so care must be taken to not exceed the recommended dosage, and in the case of overdose, immediate medical attention should be sought.

Shock, anaphylactic symptoms, respiratory distress, seizures, flushing, rash, itching, hives, skin erythema, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, epigastric pain, thirst, dental discoloration, pancreatitis, increased amylase, taste disturbances, loss of appetite, constipation, fecal discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, respiratory distress, chest X-ray abnormalities, eosinophilia, eosinophilic pulmonary infiltrate, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug eruption with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, malaise, increased CPK, elevated serum myoglobin, elevated urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disorders, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorders, tinnitus, hearing disorders, hypoglycemia, purpuric rash, acute generalized pustular psoriasis, muscle cramps, musculoskeletal stiffness, myopathy, renal failure, nephritis, phlebitis at the injection site, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine coloration, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura

Store this medication in a closed container to protect it from air and moisture. Also, for maintaining its efficacy, keep it in a cool place where moisture is low and direct light does not reach. The storage temperature should be maintained between 15 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle