Lisperin Tablet (Risperidone)

Adult dose

The therapeutic dose of this medicine should be adjusted according to the patient's clinical condition, and the lowest effective dose should be used whenever possible. Place this medicine on the tongue and, once it disintegrates within a few seconds, swallow it with or without water (orally disintegrating tablet only). 1. Schizophrenia 1) Adults (1) Initial dose: Administer risperidone 1 mg orally twice daily and increase gradually. (2) Maintenance dose: Administer 1∼3 mg twice daily. Adjust appropriately according to age and symptoms. (3) No additional benefit was observed at doses of 10 mg or more daily compared with lower doses, and the risk of extrapyramidal symptoms may increase. Doses of 10 mg or more daily should be administered only when the benefits to an individual patient are judged to outweigh the risks. (4) Do not administer doses of 16 mg or more daily, as safety has not been established. (5) A benzodiazepine may be administered concomitantly if additional sedation is needed. 2) Administration in special populations ⦁ Older adults and patients predisposed to hypotension The initial dose is 0.5 mg twice daily. Depending on the patient's condition, increase by 0.5 mg twice daily until a dose of 1～2 mg twice daily is reached. In general, increases to doses of 1.5 mg or more twice daily should be made at intervals of at least 1 week. 3) Switching from an existing antipsychotic medicine to this medicine When medically appropriate, initiate this medicine while gradually reducing the dose of the existing medicine. Also, when switching from an existing depot antipsychotic medicine, if medically appropriate, initiate this medicine in place of the next scheduled depot injection. The need to continue concomitant antiparkinsonian medicines should be reassessed regularly. 2. Agitation, aggression, or psychotic symptoms in patients with dementia of the Alzheimer type The initial dose is 0.25 mg of this medicine twice daily. If needed, depending on the patient, the dose may be increased by 0.25 mg twice daily at intervals of at least 2 days. The optimal dose for most patients is 0.5 mg twice daily, but depending on the patient, the dose may be increased to 1 mg twice daily. Once the patient reaches the optimal dose, once-daily administration may also be considered. As with symptomatic treatment, the appropriateness of continued use of this medicine should be evaluated. 3. Adjunctive therapy for manic episodes of bipolar disorder ⦁ The recommended initial dose is 2 mg of this medicine once daily. Depending on the patient, the dose may be increased by up to 1 mg daily at intervals of 24 hours or more. The optimal dose for most patients is in the range of 2∼6 mg daily. As with symptomatic treatment, the appropriateness of continued use of this medicine should be evaluated. Renal and hepatic impairment For patients with renal or hepatic impairment, administer half the initial and maintenance doses and adjust the dose more gradually. Use this medicine with caution in these patients (see 5. General Precautions).

Child dose

1. Schizophrenia: Clinical experience in children and adolescents younger than 15 years is limited. 3. Adjunctive therapy for manic episodes of bipolar disorder: Clinical experience in children and adolescents younger than 15 years is limited. 4. Conduct disorder and other disruptive behavior disorders, body weight 50 kg or more: The initial dose is 0.5 mg of this medicine once daily. If needed, depending on the patient, the dose may be increased by 0.5 mg daily at intervals of at least 2 days. The optimal dose for most patients is 1 mg once daily. Depending on the patient, 0.5∼1.5 mg may be administered once daily. 4. Conduct disorder and other disruptive behavior disorders, body weight under 50 kg: The initial dose is 0.25 mg once daily. If needed, depending on the patient, the dose may be increased by 0.25 mg daily at intervals of at least 2 days. The optimal dose for most patients is 0.5 mg once daily. Depending on the patient, 0.25∼0.75 mg may be administered once daily. 4. Conduct disorder and other disruptive behavior disorders: As with symptomatic treatment, the appropriateness of continued use of this medicine should be evaluated. 4. Conduct disorder and other disruptive behavior disorders: Clinical experience in children younger than 5 years is limited.

Caution is required when administering this medication to elderly dementia patients, as the mortality rate may be higher compared to placebo. In particular, the risk of death can increase when this drug is used in conjunction with the diuretic furosemide, so the decision to combine should be made carefully. Also, it is essential to check and take preventive measures for risk factors that may cause venous thrombosis before and during the use of this medication. This product contains the artificial sweetener aspartame, so patients with a genetic disorder called phenylketonuria should avoid it. Patients who are allergic to this drug or its components, are taking alcohol or central nervous system depressants, are in a comatose state, are undergoing epinephrine treatment, or those with certain hereditary lactose intolerance should not take this medication. This drug should be cautiously administered to patients with heart disease, liver or kidney dysfunction, a history of seizures, suicidal risk, or Parkinson's disease, with careful dosage adjustments and condition monitoring required. Various side effects like drowsiness, dizziness, hypotension, insomnia, and weight gain may occur during use, so symptoms should be closely monitored. This medication has central nervous system depressant effects, so extra caution is required when taken together with alcohol or other central nervous system depressants. Pregnant or nursing women should consult their doctor before taking this medication, as it can affect the fetus and newborn. Children and the elderly should have their dosage adjusted according to their physical condition, and in the case of overdose, they should immediately visit a medical institution for appropriate treatment. It is advisable to avoid activities that require mental concentration, like driving or operating machinery, while taking this medication. Due to numerous drug interactions, patients taking other medications should inform their doctor or pharmacist, especially when taking antihypertensives, antidepressants, or antifungal medications. This medication should be stored out of reach of children, taken immediately after opening the packaging, and not mixed with tea or cola.

Increased mortality, cerebrovascular adverse reactions, venous thrombosis, pharyngitis, upper respiratory tract infections, sinusitis, urinary tract infections, anemia, hypersensitivity reactions, insomnia, anxiety, nervousness, Parkinsonism, akathisia, drowsiness, dizziness, sedation, tremor, muscle rigidity, somnolence, orthostatic dizziness, dyskinesia, syncope, blurred vision, ear pain, orthostatic hypotension, tachycardia, hypotension, nasal congestion, dyspnea, epistaxis, sinus congestion, nausea, constipation, dyspepsia, vomiting, diarrhea, hypersalivation, dry mouth, abdominal discomfort, abdominal pain, gastric discomfort, epigastric pain, rash, dry skin, dandruff, seborrheic dermatitis, hyperkeratosis, back pain, arthralgia, limb pain, urinary incontinence, ejaculation failure, fatigue, asthenia, fever, chest pain, elevated blood creatinine phosphokinase, increased heart rate, pneumonia, soft tissue infection, decreased appetite, confusion, transient ischemic attack, decreased consciousness state, sialorrhea, cerebrovascular accident, conjunctivitis, hypotension, cough, runny nose, difficulty swallowing, stool mass, erythema, abnormal posture, joint swelling, peripheral edema, gait disturbance, pitting edema, increased body temperature, rhinitis, influenza, increased appetite, middle insomnia, fatigue, headache, stuttering, attention deficit, balance disorder, excessive sleep, palpitations, oropharyngeal pain, pulmonary congestion, pruritus, acne, myalgia, throat pain, nocturia, increased frequency of urination, galactorrhea, emotional disturbances, laziness, chest discomfort, weight gain, increased blood prolactin, restlessness, slowed affect, sleep disorders, decreased libido, sexual dysfunction, depression, nightmares, unresponsiveness to stimuli, coordination disorders, loss of consciousness, speech disorders, sensory impairment, movement disorders, generalized dyskinesia, cerebral ischemia, cerebrovascular accident dysfunction, neuroleptic malignant syndrome, diabetic coma, head tremors, seizures, psychomotor hyperactivity, delayed dyskinesia, cerebrovascular disorders, sensory disturbances, conjunctival injection, eye discharge, eye movement, eyelid edema, photophobia, eyelid crust, dry eyes, increased tearing, glare, glaucoma, decreased vision, tinnitus, vertigo, bradycardia, tachycardia, palpitations, I degree atrioventricular block, left bundle branch block, right bundle branch block, heart block, flushing, conduction disorders, ECG abnormalities, prolonged QT interval on ECG, deep vein thrombosis, bradycardia, wheezing, aspiration pneumonia, speech impairment, wet cough, airway congestion, rattling sounds, respiratory distress, nasal mucosa edema, hyperventilation, fecal incontinence, gastritis, lip swelling, cheilitis, xerostomia, bloating, gastroenteritis, tongue swelling, toothache, skin discoloration, skin lesions, skin disorders, erythematous rash, papular rash, generalized rash, papulopustular rash, eczema, musculoskeletal chest pain, joint stiffness, muscle weakness, rhabdomyolysis, urinary disorders, amenorrhea, gynecomastia, vaginal discharge, erectile dysfunction, ejaculation disorders, menstrual disorders, breast engorgement, sexual dysfunction, retrograde ejaculation, breast discharge, thirst, influenza-like syndrome, edema, lethargy, facial swelling, discomfort, systemic edema, chills, peripheral coldness, drug withdrawal syndrome, adverse drug reactions, decreased body temperature, procedure-related pain, ALT increase, ECG abnormalities, eosinophilia, AST increase, leukopenia, increased blood glucose, decreased hemoglobin, decreased hematocrit, hypothermia, low blood pressure, increased transaminases, increased γ-glutamyl transferase, increased liver enzymes, falls, agranulocytosis, thrombocytopenia, anaphylactic reaction, abnormal secretion of antidiuretic hormone, diabetic ketoacidosis, diabetes, hypoglycemia, water intoxication, increased serum cholesterol, increased serum triglycerides, mania, dysgeusia, intraoperative iris hypotension syndrome, atrial fibrillation, deep vein thrombosis, pulmonary embolism, sleep apnea syndrome, bowel obstruction, pancreatitis, jaundice, vascular edema, alopecia, neonatal drug withdrawal syndrome, urinary retention, priapism, hypothermia, prolonged QT on ECG, chest pain, liver dysfunction, hepatitis, thirst, dry mouth, urinary retention, polyuria, pain, hiccups, increased sweating, urinary disorders, leukopenia, arrhythmia, epistaxis, hangover, ocular movement seizures, acne, difficulty swallowing, enuresis, tic disorders, respiratory distress, suicidal ideation, accident abnormalities, delusions, hallucinations, exacerbation of auditory hallucinations, extrapyramidal symptoms, delayed movement disorders, neuroleptic malignant syndrome, disorientation, desensitization, postural instability, frequent falls, hyperglycemia, diabetes, weight gain, orthostatic hypotension, syncope, decreased deep body temperature, drug withdrawal syndrome, adverse drug reactions

This medication may be sensitive to air or moisture; therefore, it must be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1 degree and 30 degrees Celsius. By storing it this way, the effectiveness of the drug can be preserved for a longer period.

Appearance

Oblong light orange film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle