Dimapholmin Extended-release Tablet (Metformin Hydrochloride)

Adult dose

Take Metformin Hydrochloride Extended-release Tablet 500 mg once daily with dinner. Measure blood glucose after one week to adjust the dosage. When increasing the dosage, increase by 500 mg weekly, with a maximum daily dose of 2000 mg taken with dinner. If blood sugar control is inadequate, consider a dosage of 1000 mg twice daily, taken with meals. For patients with renal impairments

This medication can rarely cause a serious condition called lactic acidosis, so caution is required. Lactic acidosis occurs when lactate accumulates excessively in the body, and if symptoms appear, patients should immediately inform medical personnel. There is a risk of hypoglycemia when used in combination with other diabetes medications, so blood glucose status should be closely monitored. Patients with moderate to severe renal impairment or acute illnesses affecting the kidneys, such as dehydration or severe infections, should not use this medication. It should also be avoided in serious conditions like acute heart failure, myocardial infarction, and sepsis, and the medication must be discontinued before procedures using radiographic contrast agents. Patients with a history of allergic reactions to this medication or its ingredients, patients with type 1 diabetes, and those with metabolic acidosis should also not use it. Patients with severe infections, significant trauma, or before and after surgery should temporarily stop the medication, and resume only when their condition stabilizes. Caution is required for patients with poor nutritional status or liver dysfunction, and excessive alcohol intake should be avoided. During treatment, irregular meals, excessive exercise, and the use of interacting medications can increase the risk of lactic acidosis and hypoglycemia. Side effects may include vitamin B12 deficiency, gastrointestinal disturbances (such as nausea, vomiting, diarrhea), skin rashes, and while gastrointestinal symptoms commonly occur initially, they generally lessen over time. Renal function should be regularly tested, and if abnormalities are found, immediate consultation with a physician is necessary. Alcohol consumption can affect lactate metabolism, so it is advisable to avoid it during treatment. Pregnant women should consult medical personnel due to potential effects on the fetus, and nursing mothers should also consider careful judgment. Safety has not been established for pediatric patients, and elderly patients should be administered appropriate doses considering their kidney function. In the event of an overdose, dialysis may be necessary, and patients should visit a medical facility immediately. This medication should not be chewed or crushed, but swallowed whole, and it is normal for the tablet's coating to appear in the stool. Regular testing of blood sugar, kidney function, and vitamin B12 levels should be performed during treatment, and any unusual symptoms should be reported to healthcare personnel immediately.

Serious side effects

Lactic acidosis (possible in cases of acute renal failure, cardiopulmonary diseases, sepsis), severe allergic reaction (including hives), symptoms related to dehydration and renal dysfunction, hypoglycemia (in severe cases), severe edema and renal impairment, liver abnormalities (related to liver dysfunction), serious skin reactions (severe rash, blisters, skin peeling, mucosal pain), potential serious neurological symptoms (such as headache, confusion, paralysis)

Mild side effects

• Vitamin B12 deficiency
• altered taste
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• hives

This medication may be sensitive to air and moisture, so it must be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. This will help preserve the medication's effectiveness over time.

Appearance

White, bilaterally convex, rectangular extended-release tablet

Package unit

30 tablets/bottle, 300 tablets/bottle