Apitrol Oral Suspension (Megestrol Acetate)

Adult dosage

(Tablets) 1. Breast cancer: Administer megestrol acetate 160 mg orally in 4 divided doses daily (40 mg, 1 tablet per dose, 4 times daily). 2. Endometrial cancer: Administer 40～320 mg of this drug orally in divided doses daily. Treatment should be continued for at least 2 months, an adequate period for evaluating the effect of this drug. (Suspension) Shake well and take megestrol acetate 800 mg (20 mL) daily. Clinical efficacy was observed in clinical trials with this drug at doses of 400～800 mg (10∼20 mL) daily.

This medication should not be used during the first four months of pregnancy as it may cause serious damage to the fetus. Women of childbearing potential must practice contraception while using this medication as it may increase the risk of fetal malformation. Caution is advised as long-term use may lead to new-onset diabetes or worsen existing diabetes. Long-term use or abrupt discontinuation may lead to adrenal insufficiency, which can manifest as hypotension, nausea, dizziness, and other symptoms. It is important to consult healthcare providers if such symptoms occur for proper examination and treatment. Patients with a history of thromboembolic events or pulmonary embolism should be particularly cautious due to potential circulatory problems such as thrombosis. Women who are allergic to this medication or in the first four months of pregnancy should not use it. Nursing mothers should discontinue breastfeeding as this medication may pass into breast milk and harm the baby. Safety in pediatric patients has not been established, and it is advisable not to administer to children. Overdose usually does not result in severe reactions, but this drug is poorly soluble in the body and is difficult to remove through dialysis. Store this medication out of reach of children and do not transfer it to another container for safety. Accurate identification and treatment of the cause of weight loss are crucial during the use of this medication, and caution is also warranted as long-term use may increase the risk of respiratory infections.

• Thrombophlebitis
• thromboembolic symptoms
• pulmonary embolism
• glucose intolerance
• heart failure
• nausea
• vomiting
• edema
• sudden uterine bleeding
• dyspnea

This medication may be sensitive to air and moisture; therefore, it should be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 15 to 25 degrees Celsius.

Appearance

This medication is a white or cream-colored, milk-like suspension contained in aluminum foil packaging that disperses easily when shaken. It has a lemon-lime or lemon scent and flavor.

Package unit

14 packets (10 mL, 20 mL/packet)