Neurontin Capsule 100mg (Gabapentin)

Adult dose

1. Epilepsy 1) Monotherapy and adjunctive therapy in patients aged 13 years and older To achieve a maintenance dose of 900 mg/day of gabapentin, titrate gradually over the first 3 days of treatment as follows. Day 1: Administer one 300 mg capsule of this medication once daily, or one 100 mg capsule of this medication 3 times daily (gabapentin 300 mg/day) Day 2: Administer one 300 mg capsule of this medication 2 times daily, or two 100 mg capsules of this medication 3 times daily (gabapentin 600 mg/day) From Day 3: Administer one 300 mg capsule of this medication 3 times daily, or three 100 mg capsules of this medication 3 times daily (gabapentin 900 mg/day) Alternatively, as a starting dose, one 300 mg capsule of this medication may be administered 3 times daily (gabapentin 900 mg/day). The dose may be increased to 1,200 mg/day of gabapentin, and the total daily dose must not exceed 2,400 mg of gabapentin. (There are insufficient data on the safety and efficacy of doses exceeding 2,400 mg/day of gabapentin.) 3) The duration of treatment should be based on clinical requirements. Long-term treatment is generally required for epilepsy. Although there is no evidence of a rebound phenomenon (increased frequency of epileptic seizures due to sudden discontinuation of treatment), sudden discontinuation of antiepileptic drugs in patients with epilepsy may cause status epilepticus. If this medication must be discontinued or administered concomitantly with another antiepileptic drug, the change should be made gradually over at least 1 week. 2. Neuropathic pain 1) Adults (18 years and older): To achieve a maintenance dose of 900 mg/day of gabapentin, titrate gradually over the first 3 days of treatment as follows. Day 1: Administer one 300 mg capsule of this medication once daily, or one 100 mg capsule of this medication 3 times daily (gabapentin 300 mg/day) Day 2: Administer one 300 mg capsule of this medication 2 times daily, or two 100 mg capsules of this medication 3 times daily (gabapentin 600 mg/day) From Day 3: Administer one 300 mg capsule of this medication 3 times daily, or three 100 mg capsules of this medication 3 times daily (gabapentin 900 mg/day) Alternatively, as a starting dose, one 300 mg capsule of this medication may be administered 3 times daily (gabapentin 900 mg/day). If necessary, the dose may be increased to 1,800 mg/day of gabapentin within 1 week, and the total daily dose must not exceed 3,600 mg of gabapentin. The total daily dose of this medication should be divided into 3 doses. 2) The safety and efficacy of treatment for neuropathic pain for periods longer than 5 months have not been evaluated. 3. Frail patients In frail patients with low body weight or patients after transplantation, the dose of this medication should be increased in 100 mg increments. 4. Elderly patients Dose adjustment may be necessary due to age-related decline in renal function (see table). 5. Patients with renal impairment (creatinine clearance ≤80 mL/min) or patients undergoing hemodialysis: Dose adjustment is required based on the following table. 1) Dosage for patients with renal impairment: Renal function, creatinine clearance (mL/min) ≥80: Total daily dosea 900 ~ 2,400 (mg/day) Renal function, creatinine clearance (mL/min) 50 - 79: Total daily dosea 600 ~ 1,800 (mg/day) Renal function, creatinine clearance (mL/min) 30 - 49: Total daily dosea 300 ~ 900 (mg/day) Renal function, creatinine clearance (mL/min) 15 - 29: Total daily dosea 150b~600 (mg/day) Renal function, creatinine clearance (mL/min) < 15: Total daily dosea 150b~300 (mg/day) a: The total daily dose should be divided into 3 doses. b: 3 × 100 mg should be administered every 2 days. In patients with creatinine clearance below 15 mL/min, the dose should be reduced in proportion to creatinine clearance. 2) Dosage for patients undergoing hemodialysis Initial dose: 300~400 mg of gabapentin is recommended. Maintenance dose: Administer 200~300 mg of gabapentin after 4 hours of hemodialysis, and do not administer this medication on days when hemodialysis is not performed. 6. Method and duration of administration 1) This medication should be swallowed whole with plenty of fluids and may be taken with or without food. When administered 3 times daily, care should be taken to ensure that the interval between doses does not exceed 12 hours, to prevent recurrence of seizures. 2) If a dose of this medication is missed (more than 12 hours have elapsed since the most recent dose), the physician should decide whether an additional dose should be taken to make up for it. 3) When administered concomitantly with antacids containing magnesium or aluminum, this medication should be taken at least 2 hours after the antacid. This can greatly reduce the decrease in bioavailability of this medication. 4) The duration of treatment with this medication should be based on clinical requirements. If the dose of this medication is reduced, treatment is discontinued, or the medication is changed to another alternative, this should be done gradually over at least 1 week (a longer period may be required at the prescriber's discretion). 5) To reduce the main adverse reactions, such as somnolence, dizziness, fatigue, and ataxia, the first dose on the first day of treatment should be taken at bedtime.

Child dose

Adjunctive therapy in children aged 3 years to 12 years: To achieve a maintenance dose of gabapentin 30 mg/kg/day, titrate gradually over the first 3 days of treatment as follows. Day 1: administer gabapentin 10 mg/kg of body weight; Day 2: administer gabapentin 20 mg/kg of body weight; From Day 3: administer gabapentin 30 mg/kg of body weight; the dose may be increased, as needed, to a maximum of 40 mg/kg of body weight per day. The total daily dose of this drug should be divided into 3 doses.

This medication may increase the risk of suicidal thoughts or behaviors, so if mood changes or symptoms of depression occur during treatment, consultation with a physician should be done promptly. If the medication is abruptly discontinued, seizures may worsen or a status epilepticus may occur, so it should be gradually reduced according to the doctor's instructions. Long-term use may lead to weight gain, so regular weight monitoring should be conducted, and dietary control or exercise should be considered if necessary. This drug may cause drowsiness, dizziness, and motor coordination difficulties affecting the central nervous system, so it is safe to avoid driving or operating hazardous machinery at the beginning of treatment. Patients with impaired renal function should have their dosages adjusted, and elderly patients should also use caution when taking this medication. The risk of sedation and respiratory depression increases when this drug is used concurrently with narcotics or other central nervous system depressants, so it should only be combined after consulting a physician. If symptoms of acute pancreatitis (abdominal pain, nausea, vomiting, etc.) occur, the medication should be discontinued immediately and medical assistance should be sought. This drug may cause allergic reactions or serious skin reactions, so if symptoms such as rash, swelling, or difficulty breathing occur, the medication should be discontinued immediately and a hospital visit is necessary. Women who are pregnant or planning to become pregnant should consult a physician before using this medication, and caution is necessary if breastfeeding. Children, especially those aged 3 to 12 years old, should be carefully monitored for signs of emotional instability, aggressiveness, and hyperactivity, as they may experience psychiatric side effects. This medication should be taken exactly as prescribed by a doctor, and doses should not be changed or stopped arbitrarily.

suicidal thoughts, suicidal behavior, depression, abnormal changes in mood and behavior, hemorrhagic pancreatitis, emotional instability, hostility, thought disorder, hyperactivity, weakness, apathy, facial swelling, hypertension, constipation, abnormal teeth, diarrhea, dyspepsia, increased appetite, thirst, nausea, vomiting, leukopenia, peripheral edema, weight gain, fractures, myalgia, memory loss, ataxia, confusion, impaired coordination, dizziness, speech disorder, insomnia, neurogenic response, nystagmus, drowsiness, thought disorder, tremors, single contraction, cough, pharyngitis, rhinitis, erosion, acne, itching, rash, amblyopia, diplopia, erectile dysfunction, asthenia, apathy, facial swelling, allergy, generalized edema, weight loss, chills, feeling strange, lethargy, alcohol intolerance, hangover effects, hypotension, angina, peripheral vascular disorders, palpitations, tachycardia, migraine, noise, atrial fibrillation, heart failure, thrombophlebitis, myocardial infarction, cerebrovascular accident, pulmonary thrombosis, ventricular extrasystole, bradycardia, pericardial friction, heart block, pulmonary embolism, hyperlipidemia, hypercholesterolemia, pericardial effusion, pericarditis, decreased appetite, bloating, gingivitis, glossitis, gum bleeding, thirst, stomatitis, increased saliva secretion, gastroenteritis, hemorrhoids, bloody stools, fecal incontinence, liver enlargement, dysphagia, belching, pancreatitis, gastric ulcer, colitis, oral vesicles, dental discoloration, angular cheilitis, salivary gland hypertrophy, lip bleeding, esophagitis, Hiatal hernia, hematemesis, rectitis, irritable bowel syndrome, rectal bleeding, esophageal spasm, hyperthyroidism, hypothyroidism, thyroid enlargement, low estrogen, ovarian failure, epididymitis, testicular swelling, cushingoid appearance, anemia, lymphadenopathy, thrombocytopenia, increased white blood cell count, lymphocytosis, non-Hodgkin's lymphoma, prolonged bleeding time, arthralgia, tendinitis, arthritis, joint stiffness, joint swelling, benign Romberg test, costochondritis, osteoporosis, bursitis, contracture, dizziness, hyperactivity, sensory disturbances, decreased or absent reflexes, increased reflexes, anxiety, hostility, CNS tumors, syncope, abnormal dreams, aphasia, sensory loss, intracranial hemorrhage, hypotonia, abnormal sensations, incomplete paralysis, dystonia, hemiplegia, facial paralysis, confusion, cerebellar dysfunction, benign Babinski sign, decreased proprioception, subdural hematoma, flat affect, hallucinations, decreased or lost libido, restlessness, paranoia, depersonalization, ecstatic states, hypersensitivity, hallucinatory state, suicidal thoughts, mental disorders, chorea-athetosis, perioral movement disorder, brain disorders, neuropathy, personality disorders, increased libido, organic suppression, apraxia, fine motor control disorder, meningitis, focal myoclonus, hypersensitivity, decreased motor function, mania, neurosis, hysteria, antisocial response, suicidal behavior, pneumonia, nosebleeds, dyspnea, apnea, mucositis, aspiration pneumonia, hyperventilation, hiccups, laryngitis, nasal congestion, nasal furuncle, bronchospasm, hypoventilation, pulmonary edema, hair loss, eczema, dry skin, increased sweating, urticaria, hirsutism, seborrhea, cysts, herpes simplex, herpes zoster, skin discoloration, skin nodules, photosensitivity, leg ulcers, scalp seborrhea, psoriasis, epidermal sloughing, maceration, skin granulomas, subcutaneous nodules, melanosis, skin necrosis, localized swelling, hematuria, urinary disorders, polyuria, cystitis, urinary retention, urinary incontinence, vaginal bleeding, amenorrhea, menstrual disorders, heavy menstrual bleeding, breast cancer, acyclic bleeding, ejaculation disorders, renal pain, leukorrhea, genital itching, kidney stones, acute renal failure, anuria, diabetes, nephritis, nocturnal enuresis, pyuria, urinary urgency, vaginismus, mastalgia, testicular pain, vision abnormalities, cataracts, conjunctivitis, dry eye, ocular pain, photophobia, bilateral or unilateral ptosis, retinal hemorrhage, chalazia, hearing loss, ear pain, tinnitus, labyrinthitis, ear inflammation, taste loss, taste disturbances, blepharospasm, ear fullness, eye itching, accommodation abnormalities, tympanic membrane perforation, sensitivity to noise, eye focusing abnormalities, epiphora, retinopathy, glaucoma, iritis, corneal disorders, nasolacrimal dysfunction, eye degeneration, blindness, retinal degeneration, miosis, chorioretinitis, strabismus, Eustachian tube dysfunction, labyrinthitis, otitis externa, olfactory disturbances, urinary tract infection, urinary disorders, erectile dysfunction, urinary incontinence, vaginal moniliasis, mastalgia, menstrual disorders, polyuria, urinary retention, cystitis, ejaculation disorders, penile growth, gynecomastia, nocturnal enuresis, pyelonephritis, scrotal swelling, frequent urination, urgency of urination, urinary abnormalities, tongue paralysis, elevated serum creatine phosphokinase, rhabdomyolysis, acute renal failure, urticaria, allergic reactions, hair loss, anaphylaxis, angioedema, hyperglycemia, hypoglycemia, breast enlargement, chest pain, toxic epidermal necrolysis, eosinophilia, drug eruptions with systemic symptoms, elevated liver function tests, erythema multiforme, falls, generalized edema, gynecomastia, hallucinations, hepatitis, systemic reactions including hypersensitivity, hyponatremia, jaundice, loss of consciousness, chorea-athetosis, movement disorders, dystonia, myotonic spasms, palpitations, pancreatitis, sexual dysfunction, skin and mucous membrane syndrome, thrombocytopenia, tinnitus, urinary incontinence, anxiety, insomnia, nausea, pain, sweating, tremors, headache, abnormal sensation, apathy

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is advisable to maintain storage temperatures between 1 to 30 degrees Celsius to preserve the drug's effectiveness and safety for a long time.

Appearance

Hard capsules with a white or almost white powder inside, colored white on the top and bottom.

Package unit

90 capsules (10 capsules per blister X 9), 200 capsules per bottle