Konatec Tablets (Itraconazole)

Adult dosage

(Tablets)(Capsules) It is preferable to administer immediately after a meal. 1. Short-term treatment 1) Candidal vaginitis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Tinea versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis and tinea cruris (jock itch): Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital type) and tinea pedis (interdigital type): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palms) and tinea pedis (soles): Administer 100 mg once daily for 30 days, or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week drug-free period. This constitutes 1 cycle. Administer up to 2 cycles if only the fingernails are infected, and up to 3 cycles if the toenails are infected. 2) Continuous therapy Administer 200 mg once daily for 3 months. 3. Systemic fungal infections In patients with impaired immune function, increase the dose twofold if necessary. Aspergillosis: 200mg once daily, 2～5 months. For invasive or disseminated disease, increase the dose to 200mg twice daily Candidiasis: 100～200mg once daily, 3 weeks～7 months Cryptococcal meningitis: 200mg twice daily, 2 months～1 year. Maintenance therapy: 200mg once daily Paracoccidioidomycosis: 100mg once daily, 6 months (Oral solution) Do not take with food. Hold this medicine in the mouth for approximately 20 seconds so that it comes into contact with the entire mouth, then swallow. After swallowing, do not rinse the mouth so that the medicine remains in the mouth for as long as possible. 1. Oral and esophageal candidiasis Take 200 mg (20 mL) daily in 1～2 divided doses for 1 week. If there is no effect after 1 week, continue taking it for 1 more week. 2. Fluconazole-resistant oral and esophageal candidiasis Take 200～400 mg (20～40 mL) daily in 1～2 divided doses for 2 weeks. If there is no effect after 2 weeks, continue taking it for 2 more weeks. Do not use 400 mg daily for more than 14 days, even if symptoms have not improved. Prevention of fungal infections In clinical trials, prophylactic treatment was started immediately before anticancer therapy and approximately 1 week before bone marrow transplantation. Deep fungal infections were confirmed in most patients with a neutrophil count below 100/μL. Treatment was continued until the neutrophil count recovered (1,000/μL). Pharmacokinetic values obtained in clinical trials of patients with neutropenia showed considerable interindividual variability. Therefore, monitoring of blood concentrations should be considered, particularly in patients with gastrointestinal damage or diarrhea and when this medicine is administered for a long period.

Children's dosage

Prevention of fungal infections: administer 5 mg/kg of body weight per day in 2 divided doses.

This drug should not be used in patients with heart dysfunction, especially those with congestive heart failure. If symptoms of heart failure occur during treatment, it should be discontinued immediately. This drug can cause serious side effects when taken with certain medications, so it is essential to check for any contraindicated interactions. Patients with hypersensitivity to this drug or allergies to its components should not use it. It is safest not to use this drug during pregnancy or if there is a potential for pregnancy, and for breastfeeding women. Patients with liver or kidney dysfunction should exercise caution when administering this drug, and regular liver function tests are recommended. Patients with weakened immune systems or specific fungal infections may require dosage adjustments or treatment monitoring. Side effects can include headache, nausea, abdominal pain, and may rarely include severe side effects such as liver dysfunction, allergic reactions, heart irregularities, or neurological disorders. Caution is advised while driving or operating machinery as dizziness or visual disturbances may occur. There are many interactions with other medications being taken with this drug, so it should be administered only after consulting a healthcare professional. Especially, taking it alongside drugs that lower gastric acidity may reduce absorption, so it is necessary to adjust intake times or take it with acidic beverages. In case of overdose, there are no specific antidotes, so immediate medical assistance should be sought. Store out of reach of children and keep in the original container to prevent misuse or deterioration of the drug quality.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory tract infection, leukopenia, hypersensitivity, taste disorder, sensory disturbance, paresthesia, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorders, edema, granulocytopenia, thrombocytopenia, anaphylactic-like reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confused state, peripheral neuropathy, dizziness, drowsiness, tremor, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, voice disorders, cough, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, renal impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, vision disorders, temporary or permanent hearing loss, ventricular ectopic beats, atrioventricular block, palpitations, increased gastrointestinal motility, belching, glossitis, stomatitis, abdominal and lower back pain, pancreatitis, elevated total serum protein, increased total bilirubin, elevated LAP, loss of appetite, lethargy, dark urine, increased liver enzyme levels, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riehl's syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urine protein reaction, positive urine glucose reaction, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, elevated serum triglycerides, burning sensation, elevated serum uric acid levels, elevated serum potassium levels, serum sickness, angioedema, anaphylaxis reaction, hypertriglyceridemia, tremor, vision disorders, hearing loss, congestive heart failure, dyspnea, pancreatitis, significant hepatotoxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase levels

This drug should be stored in a tightly sealed container to prevent exposure to air and moisture. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius to preserve the drug's efficacy and safety effectively.

Appearance

White to off-white oval film-coated tablet

Package unit

30 tablets, 100 tablets