Levroksin Injection (Levofloxacin Hemihydrate)

Adult administration

Administered as a slow intravenous infusion 1 to 2 times a day. After the first few days of intravenous administration, it can be switched to oral administration based on the patient's condition, with the oral dose being the same as the intravenous dose. The method of administration must be solely through slow intravenous infusion, and it can be administered once or twice a day for a maximum of 14 days. The infusion time must take at least 60 minutes or more. For patients with normal kidney function (creatinine clearance > 50mL/min)

This medication is a fluoroquinolone antibiotic used for the treatment of bacterial infections. When using this drug, caution is advised as tendon-related issues such as tendinitis or tendon rupture may occur, especially with a risk of Achilles tendon rupture; if symptoms appear, the medication should be stopped immediately. Peripheral neuropathy or central nervous system adverse symptoms may also occur; if sensory disturbances or neurological symptoms arise, consult a physician immediately. Patients with myasthenia gravis may experience worsened symptoms when using this medication, thus it is advisable not to use it. This drug is primarily excreted through the kidneys, so patients with impaired kidney function require dosage adjustments and careful administration. When administered, intravenous injection of 250mg should be given slowly over at least 30 minutes, and 500mg over at least 60 minutes; if sudden drops in blood pressure or tachycardia occur, administration should be stopped immediately. This medication is not recommended for children or adolescents under 18 years of age, or for women who are pregnant or breastfeeding. Hypersensitivity reactions such as skin rash, urticaria, breathing difficulties, and anaphylaxis may occur; if any unusual symptoms appear, use should be stopped immediately and medical attention sought. Gastrointestinal symptoms such as nausea, diarrhea, and abdominal pain may occur; if severe diarrhea occurs, the possibility of pseudomembranous colitis must be considered. Neuropsychiatric symptoms may include headaches, dizziness, insomnia, anxiety, confusion, and in severe cases, hallucinations or suicidal thoughts, necessitating close monitoring of changes in mental state. This medication may interact with other drugs, so it is essential to consult with a doctor or pharmacist before use if taking anticoagulants, hypoglycemic agents, non-steroidal anti-inflammatory drugs, theophylline, etc. Excessive sunlight exposure may lead to photosensitivity reactions; hence, avoiding strong sunlight or artificial UV exposure is recommended, and if any unusual symptoms arise, discontinue use. Caution is advised as dizziness or drowsiness may occur when driving or operating machinery. In cases of overdose, central nervous system symptoms and cardiac rhythm abnormalities may arise, necessitating immediate emergency treatment, as it is not removed by hemodialysis. This medication should be stored in a sealed container away from air and light. It is essential to avoid direct sunlight and store at room temperature between 1 and 30 degrees Celsius.

Serious side effects

Urticaria, severe swelling (angioedema, facial swelling), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rashes, blisters, skin peeling, pain in oral/ocular mucosa, severe dermatological reactions, asthma attacks, respiratory abnormalities accompanied by coughing and fever, respiratory problems, yellowing of the skin or eyes (jaundice), extreme lethargy, liver dysfunction (jaundice), sudden and severe headache, lightning-like pain

Mild side effects

• Itching
• rash
• nausea
• diarrhea
• loss of appetite
• vomiting
• abdominal pain
• indigestion
• abdominal bloating
• constipation

This medication should be stored in a sealed container to prevent exposure to air or light. It is essential to avoid direct sunlight and store in a cool room temperature, ideally between 1 and 30 degrees Celsius.

Appearance

A clear yellowish liquid with a green tint in a glass vial for injection

Package unit

50mL/bottle, 100mL/bottle