Clarithromycin 250 mg Tablets

Adult dosage

○ Adults : Clarithromycin is usually administered at 250mg (potency) per dose 2 times daily; for severe infections, administer 500mg (potency) per dose 2 times daily. The duration of administration is usually 7～14 days. For patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, administer 250mg (potency) per dose 2 times daily. Do not administer for more than 14 days to these patients. ○ Mycobacterial infections : Administer 500mg (potency) of this medicine per dose 2 times daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcer : Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and administer omeprazole 40mg once daily for 28 days (days 1～28). ○ Children 12 years of age and older: Same as adults

Children's dosage

For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used by patients who are allergic to specific components. Particularly, caution should be exercised if there is a history of allergies to antibiotics of a similar class. Patients taking heart-related medications or certain neurological drugs should avoid concurrent use with this medication, as it may cause cardiac rhythm abnormalities. Patients with severely impaired liver or kidney function should also avoid using this medication. Pregnant or breastfeeding women should not take this medication. This medication is not administered to patients with gastrointestinal infections or central nervous system infections. Elderly patients, patients with poor liver function, and patients with heart disease should use this medication with caution. Caution is needed as cross-resistance or side effects may occur when used in conjunction with other antibiotics. If allergic symptoms, severe skin rashes, or respiratory difficulties occur while taking this medication, it should be discontinued immediately and medical consultation should be sought. Gastrointestinal disturbances such as dyspepsia, diarrhea, and abdominal pain may occur, and in severe cases, pseudomembranous colitis may develop, so caution is required. This medication may cause various side effects, such as liver dysfunction, kidney dysfunction, and blood abnormalities, necessitating regular check-ups. Heart issues like arrhythmias or QT prolongation may occur, so patients with heart disease should be especially cautious. This medication has many interactions with other drugs, thus dosage adjustments or monitoring may be needed depending on the concomitant medications. Pregnant or breastfeeding women should not use this medication, and breastfeeding should be halted if unavoidable. The safety for children has not been sufficiently confirmed, so use in children under 12 years should be avoided. Elderly patients may require dosage adjustments due to potential increased drug concentrations from decreased kidney function. In the case of overdose, gastrointestinal symptoms and neurological abnormalities may present, necessitating an immediate visit to a healthcare facility. This medication should not be refrigerated during storage; it should be kept away from direct sunlight in a cool place.

Shock, anaphylactic symptoms, shortness of breath, convulsions, redness, rash, itching, urticaria, skin redness, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, tooth discoloration, pancreatitis, increased amylase, altered taste, loss of appetite, constipation, discoloration of stool, membranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disturbance, hearing loss, paraesthesia, arthralgia, myalgia, olfactory impairment, hypoglycemia, tinnitus, auditory impairment, purpuric rash, acute generalized pustular psoriasis, muscle spasms, musculoskeletal stiffness, myopathy, elevated serum creatinine, elevated serum urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, sweating, papular rash, acne, Henoch-Schonlein purpura

This medication should be stored in a tightly sealed container that is protected from light, preferably at a cool room temperature, between 1 and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness for a longer period.

Appearance

Yellow oval film-coated tablet with a vanilla flavor

Package unit

Company packaging unit