Tusep Tablet (Cefprozil Hydrate)

Adult dose

○ Adults (13 years of age and older) 1) For pharyngitis and tonsillitis among upper respiratory tract infections, administer cefprozil 500mg (potency) once every 24 hours. For acute sinusitis, administer 250mg (potency) or 500mg (potency) every 12 hours (dose increase is required for moderate or more severe infections). 2) For bacterial superinfection of acute bronchitis or bacterial exacerbation of chronic bronchitis among lower respiratory tract infections, administer 500mg (potency) of this medicine once every 12 hours. 3) For uncomplicated skin and soft tissue infections, administer 250mg (potency) of this medicine every 12 hours [or 500mg (potency) every 24 hours], or, depending on symptoms, administer 500mg (potency) every 12 hours. 4) For uncomplicated urinary tract infections, administer 500mg (potency) of this medicine every 24 hours. <Duration of administration> Treatment is usually given for about 10 days; however, for pharyngitis/tonsillitis caused by Streptococcus pyogenes (Group A beta-hemolytic), administer for 10 days or longer. For uncomplicated cystitis, administer for about 7 days. ○ Patients with renal impairment 1) If creatinine clearance is 30～120mL/min, administer according to the standard dose and regimen above. 2) If creatinine clearance is 29mL/min or less, administer 50% of the standard dose, using the same dosing interval as the standard regimen. However, some of this medicine is removed by hemodialysis, so administer it after hemodialysis is completed. Once reconstituted, store refrigerated and take within 14 days (syrup only).

Child dose

○ Children (2～12 years) — Pharyngitis and tonsillitis among upper respiratory tract infections: Administer 7.5mg (potency) per kg of body weight per dose every 12 hours. ○ Children (2～12 years) — Uncomplicated skin and soft tissue infections: Administer 20mg (potency) per kg of body weight per dose every 24 hours. ○ Infants and children (6 months～12 years) — Otitis media among upper respiratory tract infections: Administer 15mg per kg of body weight every 12 hours. ○ Infants and children (6 months～12 years) — Acute sinusitis: Administer 7.5mg per kg of body weight every 12 hours. ○ Infants and children (6 months～12 years) — Moderate or more severe infections requiring a dose increase: Administer 15mg per kg of body weight every 12 hours.

This medication is a cephalosporin antibiotic and should not be administered to patients with a history of specific allergies. In particular, it should not be used in patients who have shown hypersensitivity reactions to cephalosporins. Patients allergic to penicillin or other drugs should use this medication with caution. Those with decreased kidney function should have their dosage adjusted and monitored closely. If kidney function is poor, the drug may remain in the body for a long time, increasing the risk of side effects. Patients with a history of gastrointestinal diseases, especially colitis, should exercise caution when using this drug, and those allergic to the color additive Yellow No. 5 should also use it carefully. While taking this medication, gastrointestinal side effects such as diarrhea, nausea, vomiting, and abdominal pain may occur, and liver function tests may show temporary increases. Rarely, allergic reactions such as skin rashes or hives may occur, and central nervous system symptoms like dizziness, headaches, and drowsiness have been reported. Patients with decreased kidney function may experience seizures, and if such symptoms occur, administration must be discontinued immediately. Furthermore, caution is advised if taken with certain other antibiotics or diuretics, as they may increase nephrotoxicity. During pregnancy, it should only be used when necessary, and if breastfeeding, caution is required as the effects on the infant are unknown. It is advisable not to use in infants under 6 months due to non-establishment of safety. Elderly patients may require dosage adjustments due to decreased kidney function. Long-term use of this medication may result in the development of resistant strains or other infections; therefore, it should be used for the minimum duration as directed by a physician. If diarrhea occurs after antibiotic use, consider the possibility of pseudomembranous colitis, and if symptoms are severe, consult a healthcare provider immediately. In cases of overdose, blood dialysis may be necessary for patients with impaired kidney function, so it is important to adhere to the prescribed dosage. This medication may affect the results of certain clinical tests; therefore, inform medical staff that you are taking this medication prior to such tests.

• Diarrhea
• nausea
• vomiting
• abdominal pain
• elevated AST
• elevated ALT
• elevated ALP
• increased bilirubin levels
• rash
• urticaria

This medication is sensitive to light and should be stored in a container that blocks light. It is also recommended to store it at room temperature between 1 and 30 degrees Celsius. Proper storage can maintain the drug's effectiveness for a longer duration.

Appearance

Oblong, light yellow film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle