Clopidogrel Sulfate Tablet 75 mg

Adult dose

Adults 1. In patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel 75 mg orally once daily. 2. In patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start with a loading dose of 300 mg once daily on the day treatment with this medicine is initiated, followed by an oral maintenance dose of 75 mg once daily. In this case, aspirin 75 ～ 325 mg must be administered once daily in combination with this medicine. 3. In patients with atrial fibrillation, administer this medicine 75 mg orally once daily. In this case, aspirin 75 ～ 100 mg must be administered once daily in combination with this medicine. Patients with renal impairment : Treatment experience in patients with renal impairment is limited. Patients with hepatic impairment : Treatment experience in patients with moderate liver disease and a bleeding diathesis is limited. This medicine may be administered with or without food.

This medication helps prevent platelets from aggregating, facilitating smooth blood flow. Before taking this medication, individuals with a genetic deficiency in a specific enzyme (CYP2C19) may have reduced efficacy; therefore, alternative treatment options should be considered in consultation with a physician. Additionally, taking this medication with drugs that enhance enzyme activity may increase drug concentration and elevate bleeding risk; hence, such combinations should be avoided. This medication should not be taken if there is an allergy to it or its components, in cases of bleeding, severe liver impairment, or if breastfeeding. Patients with genetic issues like lactose intolerance should also avoid taking this medication. Patients at high risk of bleeding, such as those with symptoms of bleeding disorders or issues with blood coagulation, should use this medication cautiously. Patients scheduled for surgery should stop taking this medication 5-7 days prior to surgery and resume it after hemostasis is achieved. This medication may further elevate the risk of bleeding when taken with other bleeding-risk medications. Particularly when taken with drugs like aspirin or warfarin, bleeding risk may increase, so follow a physician's guidance. While taking this medication, it may take longer to stop any bleeding; therefore, if bleeding is severe or persists, consult a doctor immediately. This medication can rarely cause a serious blood condition called Thrombotic Thrombocytopenic Purpura (TTP); if symptoms such as thrombocytopenia, anemia, or renal failure occur, consult healthcare providers immediately. During pregnancy, although effects on the fetus have not been confirmed, there may be an increased risk of bleeding at delivery, so it is advisable to discontinue use 5-7 days prior to delivery. If breastfeeding, since it is not certain whether this medication is excreted in breast milk, discuss whether to continue breastfeeding or discontinue the medication with a physician. Elderly patients and those with impaired renal or liver function may have an increased risk of bleeding; thus, dosage adjustment and monitoring of condition are necessary. Overdosage may increase the risk of bleeding, and as there is no specific antidote, platelet transfusion may be necessary to prevent bleeding. This medication should be kept out of reach of children, and transferring it to another container may affect its quality.

Hemorrhage, gastrointestinal bleeding, admission-required bleeding, purpura, contusion, hematoma, epistaxis, hematoma, hematuria, intraocular bleeding, intracranial hemorrhage, significant bleeding, minor bleeding, severe bleeding, fatal bleeding, hemorrhagic stroke, thrombocytopenia, neutropenia, agranulocytosis, aplastic anemia, abdominal pain, dyspepsia, diarrhea, nausea, rash, pruritus, depression, dyspnea, rhinitis, bronchitis, cough, urinary tract infection, headache, dizziness, chest pain, accidental injury, influenza-like illness, pain, fatigue, edema, hypertension, purpura, hematochezia, thrombocytopenia, anemia, pneumonia, sinusitis, eczema, skin ulcer, cystitis, cataract, conjunctivitis, allergic symptoms, ischemic necrosis, gastritis, hemorrhagic gastritis, duodenal ulcer, gastric ulcer, perforated gastric ulcer, upper gastrointestinal tract ulcer bleeding, bloating, hyperbilirubinemia, infectious hepatitis, fatty liver, thrombocytopenia, thrombocytopenia, vasculitis, hypotension, bronchospasm, interstitial pneumonia, eosinophilic pneumonia, colitis, pancreatitis, gastritis, stomatitis, hepatitis, acute liver failure, petechial papules, erythematous skin rash, urticaria, itching, angioedema, vesicular dermatitis, drug-induced hypersensitivity syndrome, eosinophilia, drug rash, eczema, lichen planus, arthralgia, arthritis, myalgia, glomerulopathy, gynecomastia, fever, abnormal liver function tests, elevated blood creatinine, decreased motor function, tremor, speech disorders, abnormal gait, hyperkinesia, ataxia, paresthesia, insomnia, depression, amnesia, anxiety, psychological symptoms, abnormal behavior, weight loss, weight gain, facial flushing, weakness, rigidity, facial edema, syncope, visual disturbances, field defects, dry eyes, transient blindness, congestion, tinnitus, urinary disorders, polyuria, increased non-protein nitrogen, uremia, hypoglycemia, hyperuricemia, elevated liver enzymes, increased ALT, liver dysfunction, leg edema, arrhythmia, bradycardia, palpitations, rash, itching, contact dermatitis, elevated prostate-specific antigen, cholecystitis, hematemesis, spinal hematoma

This medication should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle