PN-MIX Injection No. 2

Adult dosage

Prior to administration, the partition should be opened to mix solution A and B. The maximum dosage for total amino acids should not exceed 1-1.5g per kg of body weight per day. The administration speed should not exceed 1.0mL per hour (equivalent to 0.25g/kg of glucose and 0.05g/kg of amino acids), and it is preferable to administer it intravenously over 12 to 24 hours.

Children's dosage

For children, dosage and infusion speed should be adjusted accordingly.

This medication must be used strictly according to a physician's instructions. When administering intravenously, it should not be infused simultaneously with calcium-containing preparations as this can cause precipitation between the drugs when using the same infusion equipment. Patients with allergic reactions or specific electrolyte imbalances, heart, and kidney diseases should not use this medication. In patients with impaired liver or kidney function, severe dehydration, or heart failure, this medication should be administered cautiously, and their condition must be closely monitored during administration. This medication contains sodium bisulfite, which may provoke allergic reactions or asthma attacks, so individuals with hypersensitivity should exercise caution. During administration, blood glucose, electrolytes, and liver and kidney functions should be regularly monitored, and any abnormal symptoms should be reported to medical professionals immediately. Pregnant or breastfeeding individuals should administer this medication cautiously as its safety has not been established, and a physician's evaluation is necessary. Children and the elderly may require dosage speed adjustments or special caution due to different physiological functions. In cases of overdose, acidosis, fluid overload, and electrolyte imbalances may occur; thus, dosage and infusion speed must be strictly managed, and infusion should be stopped immediately if symptoms arise and appropriate interventions must be taken. This medication must be administered slowly via central venous access and peripheral intravenous access should be avoided. Before use, check for abnormalities in the solution, use it promptly after opening, and do not reuse any remaining solution.

Serious side effects

• Urticaria, rash → severe allergic reactions.
• Dyspnea, respiratory arrest, asthma attacks → respiratory problems.
• Shock → acute shock condition.
• Severe edema (peripheral edema, pulmonary edema), cerebral edema → severe edema or edema-related complications.
• In patients with liver failure, systemic nitrogenemia, hyperammonemia, loss of perception, coma → liver abnormalities and serious neurological symptoms.
• Hypertension accompanied by increased blood pressure → severe edema or urination abnormalities.
• Severe headache.

Mild side effects

• Nausea, vomiting, chills, fever, headache, palpitations, tachycardia, hypertension, chest discomfort, blood pressure fluctuations (hypertension/hypotension), urinary retention, peripheral vasodilation, gastrointestinal disturbances.
• Mild liver function abnormalities (elevation of AST, ALT), hyperglycemia, hyperkalemia, elevated BUN, hypophosphatemia, alkalosis, osmotic diuresis and dehydration, rebound hypoglycemia, vitamin deficiencies and excesses, electrolyte imbalances.

This medication should be stored in a sealed container to protect it from air and moisture. The storage temperature should be maintained between 1 and 25 degrees Celsius at room temperature. Proper storage will help safely maintain the medication's effectiveness.

Appearance

A transparent liquid filling in a clear plastic container that is separated by a partition inside, colorless to pale yellow.

Package unit

1000mL / Box