Prezol (Aiac)

Adult administration

This solution is used as perfusion fluid in cases of hemodialysis using a bicarbonate-type dialysis device with a dilution ratio of this solution 1 : Prezol (B) 1.225 : purified water 32.775. 5L is used at one time. This medication, purified water, and Prezol (B) solution should be mixed according to the specified dilution ratio in the artificial kidney hemodialysis supply device, formulating the bicarbonate-type dialysate over an average duration of 4 to 6 hours.

This medication should not be used in patients with low blood pressure and rapid heart rate. Patients with pulmonary edema or significant abnormalities in ECG should not receive this medication. The use of this medication is prohibited in patients with hyperkalemia (high potassium levels). Patients with blood clotting issues should avoid this medication. It should be used cautiously in patients with very poor liver function or those with severe metabolic disorders due to diabetes. Patients taking digitalis preparations should be cautious as this medication can lower blood potassium levels and cause toxic symptoms. There is a risk of hypoglycemia in patients with insufficient calorie intake or those using meal restrictions or blood sugar-lowering agents due to diabetes. This medication can cause hypoglycemic symptoms, so when symptoms of low blood sugar appear, especially during or after dialysis, prompt administration of glucose injection or sugar supplementation is required. In cases where complications like osteoporosis or osteomalacia occur, it is recommended to administer active form vitamin D3 preparations together. Abnormal calcification may occur, so it may be necessary to use phosphate binders to maintain serum phosphate levels within a normal range. If symptoms such as headache, nausea, vomiting, seizures, or altered consciousness occur during dialysis, measures such as reducing dialysis intensity may be necessary. This medication may affect the circulatory system, causing low blood pressure or shock symptoms; if these symptoms occur, dialysis should be stopped, or intravenous fluids and antihypertensive agents should be administrated. If blood pressure actually increases, measures such as the use of antihypertensive drugs or changing the type of dialysate may be necessary. This medication is used for hemodialysis in chronic renal failure patients and is suitable for patients with insufficient metabolic acidosis improvement, hypotension, or dialysis disequilibrium syndrome. In patients with hyperglycemia due to abnormal glucose metabolism, this medication without glucose can help in regulating blood sugar levels. It is a dialysate with low potassium, calcium, and magnesium concentrations, making it suitable for patients with hyperkalemia or hypercalcemia. Regular checks of electrolytes, acid-base balance, and blood tests should be conducted to continuously monitor the patient’s condition. Women who are pregnant or may become pregnant should use this medication only when the benefits outweigh the risks, as its safety has not been established. The safety of this medication in children has not been established yet, so caution is required. Elderly individuals may have a risk of bone complications while using this medication, thus requiring regular monitoring and appropriate therapy. Overdose may cause alkalosis or hypokalemia, so caution should be exercised. Dialysis dilution water should be thoroughly purified, and precautions should be taken against dialysis membrane rupture or bleeding tendencies. When preparing, each solution should not be used alone and must be accurately prepared using the specified dilution solution, as improper concentration may lead to severe side effects. The electrolyte concentration and pH of the dialysate should be checked before use, and contaminated or altered dialysate should not be used. This medication should be used under the supervision of a physician experienced in dialysis and is not for use in injections or peritoneal dialysis. The dialysate should be used as soon as possible after preparation and should be warmed to body temperature before use.

Serious side effects

• Altered consciousness
• seizures
• hypotension
• increased blood pressure
• palpitations
• rapid blood pressure decrease
• headaches (including severe headaches)
• altered consciousness

Mild side effects

• Hypoglycemia
• osteoporosis
• osteomalacia
• fibrous osteitis
• ectopic calcification
• headache
• nausea
• vomiting
• seizures
• altered consciousness

This medication may be sensitive to air or moisture; thus, it should be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1 degree and 30 degrees Celsius. This helps maintain the effectiveness of the medication and prevents deterioration.

Appearance

Colorless and transparent artificial kidney perfusion solution with a vinegar smell filled in a polyethylene container

Package unit

10L/can