Nuroxime Tablet (Cefuroxime Axetil)

Adult dose

For optimal absorption, take after meals. Adults 1) Most infections Administer 250mg twice daily. 2) Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by organisms with low susceptibility Administer 500mg twice daily. 3) Urinary tract infections Administer 250mg twice daily. 4) Uncomplicated gonorrhea Administer 1g as a single dose. 5) Lyme disease Administer 500mg twice daily for 14 days (10~21 days). For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this medicine should be administered for 7~10 days. 3. Patients with renal impairment Cefuroxime is excreted primarily by the kidneys. To compensate for delayed excretion in patients with significantly impaired renal function, it is recommended that the cefuroxime dose be reduced as follows. ≥ 30 mL/min/1.73m2: No dose adjustment necessary (standard dose: 125mg-500mg twice daily) 10 - 29 mL/min/1.73m2: Administer a standard single dose every 24 hours < 10 mL/min/1.73m2: Administer a standard single dose every 48 hours Patients undergoing hemodialysis: Administer an additional standard single dose at the end of each dialysis session

Child dose

Children aged 12 years and older 1) Most infections: Administer 250mg twice daily. 2) Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by organisms with low susceptibility: Administer 500mg twice daily. 3) Urinary tract infections: Administer 250mg twice daily. 4) Uncomplicated gonorrhea: Administer 1g as a single dose. 5) Lyme disease: Administer 500mg twice daily for 14 days (10~21 days). Children under 12 years, most infections: Administer 125mg twice daily. Otitis media in children aged 2 years and older, severe infections: Administer 250mg twice daily. Lyme disease in children under 12 years: Administer 250mg twice daily for 14 days (10~21 days). There is limited experience with use in infants under 3 months of age.

This medication should not be used in patients with hypersensitivity to cephalosporin antibiotics. Caution should be exercised in patients with a history of allergy to penicillin or other beta-lactam antibiotics, patients prone to allergic symptoms such as bronchial asthma, skin rashes, and urticaria, and patients with severely impaired renal function. Although this drug typically shows mild and transient adverse reactions, serious skin reactions, blood abnormalities, liver dysfunction, and renal impairment can occur rarely, necessitating careful monitoring. Dizziness, headaches, or gastrointestinal symptoms may occur during use, and if severe diarrhea or abdominal pain occurs, immediate consultation with a healthcare professional is required. To prevent the development of antibiotic-resistant bacteria, it is advisable to administer this medication for the minimum necessary duration. While taking this drug, allergic reactions or shock symptoms may occur, therefore, attention should be paid to symptoms, and if symptoms such as discomfort, oral mucosa abnormalities, wheezing, dizziness, or sweating appear, the administration should be stopped immediately. Additionally, this drug may lead to excessive proliferation of Candida or serious gastrointestinal diseases such as pseudomembranous colitis, so caution is needed for long-term use. Caution is advised when driving or operating machinery due to the possibility of dizziness. Women who are pregnant or breastfeeding should carefully consider the benefits and risks of using this drug if needed, as the medication can be transmitted through breast milk. Caution is also necessary for children, especially infants under 3 months of age, as safety has not been established, and atypical syrup formulations are advisable for young children due to the unpleasant taste. Elderly patients may experience more adverse reactions due to decreased physiological functions and increased risk of bleeding due to vitamin K deficiency, hence careful adjustment of dosage and intervals is necessary. This medication may affect the results of certain clinical tests, so informing the healthcare professional during testing is important. In case of overdose, convulsions due to brain stimulation may occur, so immediate medical attention should be sought. Finally, this medication should be stored out of reach of children and kept in its original container with the lid tightly closed to ensure safety.

• Candidiasis overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• erythrocytopenia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This medication should be stored in a tightly sealed container to prevent air exposure, at room temperature between 1 and 30 degrees Celsius. Proper storage will maintain the drug's efficacy and safety.

Appearance

White rectangular film-coated tablet

Package unit

50 tablets (10 tablets/PTP*5)