Nutriflex 48 Injection

Adult administration

As total amino acids, a maximum dosage of 1 to 1.5 grams per kg of body weight per day is preferred, with an infusion rate where the concentration of total amino acids is about 10 grams over 60 minutes. The infusion rate should be administered at a rate of 25 to 30 drops per minute. Central venous administration is the principle.

Child administration

In pediatric cases, the dosage and infusion rate should be appropriately adjusted.

This medication must be used strictly according to a physician's instructions. It should not be mixed with other medications containing calcium, such as ceftriaxone, when administered intravenously. Using the same infusion device for simultaneous administration may lead to the formation of dangerous precipitates. This medication should not be administered to patients with severe liver dysfunction or hepatic coma, patients with severely impaired kidney function, or patients with severe heart failure or pulmonary edema. Additionally, it is safe not to use in cases of hypernatremia, atrioventricular block, myasthenia gravis, metabolic acidosis, and diabetic complications excluding hypoglycemia, as well as in infants. Careful administration is required for patients with heart failure, kidney failure, liver dysfunction, pancreatic disorders, diabetes, dehydration, etc., and the patient's condition should be closely monitored during administration. Various adverse reactions such as acidosis, hypersensitivity reactions, gastrointestinal symptoms, palpitations, elevated blood pressure, chills, fever, vascular pain, headache, peripheral vascular dilation, hypophosphatemia, alkalosis, hyperglycemia, osmotic diuresis, dehydration, rebound hypoglycemia, elevated liver enzymes, vitamin deficiencies, vitamin excess, electrolyte imbalances, hyperammonemia in children, intolerance reactions, osmotic diuresis, and dizziness may occur during the administration of this medication, so caution is needed. Particularly, when administered rapidly in large volumes, serious side effects such as acidosis or hyperazotemia may occur, so the infusion rate should be adjusted. This medication can affect blood sugar, electrolytes, and acid-base balance, so regular monitoring and management of blood sugar and electrolyte status are required. Excessive fluid supply should be avoided in patients with kidney, lung, or heart disease, and diabetic patients should monitor blood sugar levels frequently. During pregnancy, safety has not been established, so it should only be administered under a physician’s judgment when absolutely necessary. It should not be used in infants and it is preferable to use specially formulated amino acid preparations for pediatric patients. Elderly patients should have the infusion rate slowed and dosage adjusted due to decreased physiological function. In case of overdose, symptoms such as dizziness, nausea, osmotic diuresis may appear, and in severe cases, discontinuation of the medication and professional treatment is necessary. This medication is a hypertonic preparation and should only be administered slowly via central venous access, and strict aseptic conditions must be maintained during administration. When storing, keep it in a sealed container away from air and light at room temperature, and do not use expired products. The mixed solution is stable for 24 to 28 hours, so it must be used within this period.

Serious side effects

Severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), respiratory problems (dyspnea, respiratory arrest, shock, bronchoconstriction), severe skin reactions (severe rash, blisters, skin peeling, oral/ocular mucosal pain), liver abnormalities (liver failure, jaundice, generalized fatigue), serious neurological symptoms (severe headache, confusion, visual disturbances, paralysis), severe edema or urinary abnormalities (severe

Mild side effects

• Nausea
• vomiting
• rash
• chest discomfort
• palpitations
• rapid pulse (tachycardia)
• elevated blood pressure
• chills
• fever
• vascular pain

This medication should be stored in a sealed container to avoid exposure to air and light, and it should be kept in a cool place between 15 to 25 degrees. Proper storage will help maintain the effectiveness of the medication and prevent deterioration.

Appearance

A clear liquid (mix of liquid A and B) filled in a transparent plastic container made of polyamide II (outer casing) and polypropylene (inner casing) with a light yellow color.

Package unit

Bag - 1000 milliliters/Bag