Crestor 20mg (Rosuvastatin Calcium)

Adult dose

In primary hypercholesterolemia and other related conditions, the drug can be administered once daily at any time of the day regardless of meals. The initial dose is 5 milligrams once daily, with adjustment to 10 milligrams once daily after an interval of 4 weeks or more if necessary. The maximum dose is 20 milligrams once daily.

Child dose

For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), administer once daily in the range of 5 milligrams to 20 milligrams. Dosage should be adjusted every 4 weeks or more, as required.

This drug should not be used in certain patients. For example, patients with allergies to this medication, severely impaired liver function, muscle disorders, specific renal dysfunction, pregnant or breastfeeding women, and fertile women not using adequate contraception should not take this medication. Additionally, patients at high risk for muscle disorders, such as those with moderate to severe renal impairment, hypothyroidism, a family history of muscle disorders, alcoholics, Asians, and patients taking fibrate drugs are prohibited from receiving high doses of this medication. This medication contains lactose; therefore, patients with lactose intolerance or related genetic diseases should not take it. Caution is needed for patients consuming excessive alcohol or with a history of liver disease while taking this medication, and repeating liver function tests before and during treatment is recommended. Moreover, if symptoms such as muscle pain, weakness, or cramps occur, they should immediately inform their healthcare provider. Patients at high risk for muscle-related side effects must carefully weigh the risks and benefits of treatment, and muscle enzyme levels should be checked before starting treatment; if abnormalities are found, administration should not begin. Severe muscle weakness or ocular myasthenia may occur; hence, discontinuation of the medication should be considered if symptoms appear. This medication, when used in combination with certain other drugs, may increase serum concentration and raise the risk of muscle side effects, so patients should consult their healthcare provider about concomitant medications. It should not be used during pregnancy or while breastfeeding, and women of childbearing potential should use suitable contraceptive methods. In case of overdose, there is no specific antidote, and treatment should be symptomatic; liver function and muscle enzyme levels should be regularly monitored. Dizziness may occur while driving or operating machinery, so caution is advised. Rarely, serious side effects such as severe skin reactions, liver damage, neurological abnormalities, and muscle rupture may occur, so if unusual symptoms arise, patients should immediately inform their healthcare provider. Lastly, the drug's plasma concentration may be higher in Asians; thus, dosage adjustments may be necessary.

Serious side effects

Allergic reactions including hives, angioedema, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), jaundice, hepatitis, hyperbilirubinemia, liver failure, rhabdomyolysis, myopathy, immune-mediated necrotizing myopathy, muscle rupture, severe muscle weakness, ocular myasthenia, respiratory distress, interstitial lung disease, acute renal failure, oliguria, increased serum creatinine, severe skin aberrations

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• rash
• myalgia
• weakness
• diarrhea

This medication is sensitive to air and humidity; therefore, it should be stored in a tightly sealed container. It is important to maintain storage temperatures between 1°C and 30°C. Proper storage will help preserve the medication’s effectiveness.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 30 tablets (15 tablets/PTP x 2)