Isilin S Tablets (Amoxicillin and Potassium Clavulanate (7:1))

Adult dose

For adults with severe infections and respiratory infections, take 2 tablets orally twice a day every 12 hours. In cases of renal failure, the dosage may be reduced according to the degree of renal function. This medication should not be administered to patients with severe renal impairment (glomerular filtration rate below 30 mL/min).

This medication should not be used in patients with hypersensitivity to beta-lactam antibiotics, including penicillins and cephalosporins. Extra caution is required in patients with infectious mononucleosis or lymphocytic leukemia due to a heightened risk of rash. Patients with liver function impairment should use this medication cautiously as it may worsen symptoms. Patients with moderate to severe renal impairment may experience increased blood concentrations of the drug, requiring adjustment of dosing intervals. Patients with allergies or family history of allergies should be carefully monitored for the possibility of hypersensitivity reactions. Elderly patients or those in poor health may be at risk of bleeding due to vitamin K deficiency, requiring appropriate management. Gastrointestinal symptoms such as diarrhea, abdominal pain, nausea, and vomiting may occur; in severe cases, pseudomembranous colitis may develop, necessitating immediate consultation with a physician upon symptoms appearing. Symptoms of liver functional impairment have also been reported; long-term use may require liver function testing, particularly in males over 60 years. Rarely, serious allergic reactions such as rashes, urticaria, and anaphylactic shock may occur, and treatment must be discontinued immediately with urgent medical attention. Abnormal results in blood tests may show leukopenia or thrombocytopenia, thus regular blood testing is recommended. Pregnant women in early pregnancy or during pregnancy should only use this medication in exceptional cases, and breastfeeding women should exercise caution as side effects could occur in the baby. Pediatric use is advised only for those aged 12 years or older or weighing over 40 kg. This medication may interact with other drugs; therefore, patients must inform healthcare providers about any other medications they are taking. In case of overdose, gastrointestinal symptoms, renal impairment, or central nervous system abnormalities may occur, requiring immediate contact with a medical institution for appropriate care. This medication should be stored in a sealed container in a dry place below 25 degrees Celsius, and it is crucial to adhere to the prescribed duration and dosage.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylactic shock, severe allergic reactions, severe skin adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, blistering dermatitis), high fever with severe rash, blisters, skin peeling, mucosal pain in mouth/eyes, respiratory problems (including bronchospasm, laryngeal edema), liver abnormalities (jaundice, cholestatic jaundice, hepatitis), severe edema, urine volume

Mild side effects

• Diarrhea
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain
• abdominal bloating

This medication should be kept in a sealed container to prevent moisture ingress and stored in a cool, dry place between 1 and 25 degrees Celsius. It is advisable to avoid direct sunlight and places with high humidity.

Appearance

White oval film-coated tablet

Package unit

8 tablets/PTP X 10