Unilevo Tablet (Levofloxacin Hemihydrate)

Adult dose

For typical adult use, levofloxacin is taken orally at a dose of 100 mg, 2 to 3 times per day. For severe cases or when response is inadequate, the dose may be increased to 200 mg, 3 times per day. Adjustments should be made according to age and symptoms.

This drug is a fluoroquinolone antibiotic and is used for the treatment of specific bacterial infections. However, it may cause tendon-related problems such as tendonitis or tendon rupture, peripheral neuropathy, adverse central nervous system reactions, and exacerbation of myasthenia gravis, thus caution should be exercised. If serious adverse reaction symptoms appear, the use of this drug should be discontinued immediately, and it should not be administered to patients with myasthenia gravis. Additionally, it should only be used when there are no other treatment options in cases of acute bacterial non-sinusitis, acute exacerbation of chronic bronchitis, simple urinary tract infections, and acute otitis media. Care should be taken when administering this drug to elderly patients, patients with decreased renal function, solid organ transplant patients, and when used in conjunction with corticosteroids, as the risk of tendon rupture increases. Also, if taken along with corticosteroids, the risk of tendonitis or tendon rupture increases, so steroid medications should not be used during this treatment. Patients with myasthenia gravis may experience worsening symptoms when taking this drug, and therefore it should be administered very cautiously. It should not be used in patients with allergic reactions or hypersensitivity to this drug, those with a history of tendonitis or tendon rupture due to this drug, individuals under 18 years of age, pregnant or breastfeeding women, and patients with epilepsy. Dosage should be cautiously determined for patients with severely impaired renal function, those with a history of cerebrovascular disease or seizures, patients taking certain non-steroidal anti-inflammatory drugs or theophylline, diabetic patients, patients with glucose-6-phosphate dehydrogenase deficiency, those with a history of aortic aneurysm or valvular heart disease. This medication can cause serious allergic reactions, neuropsychiatric symptoms (insomnia, dizziness, hallucinations, seizures, delirium, disorientation, attention deficits, nightmares, sleep disorders, suicidal thoughts, etc.), cardiac arrhythmias, renal and liver dysfunction, blood abnormalities, gastrointestinal issues, musculoskeletal abnormalities, and severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, etc.). In addition, this drug may cause photosensitivity reactions, so strong sunlight or artificial UV exposure should be avoided, and caution should be exercised when driving or operating machinery if dizziness or drowsiness occurs. This drug may interact with various medications, so caution is needed when taken with antacids, iron, calcium, vitamins, theophylline, warfarin, cyclosporine, probenecid, cimetidine, etc. Especially when used in combination with diabetic medications, blood glucose fluctuations may occur, necessitating careful monitoring of blood glucose levels. It should not be administered to pregnant women or those who may become pregnant, breastfeeding mothers, or growing children and adolescents. Elderly patients may experience increased serum levels due to diminished renal function, and there is an increased risk of hepatotoxicity and aortic-related adverse reactions, hence dose adjustment and monitoring are required. In case of overdose, central nervous system symptoms and cardiac side effects may occur; prompt treatment is needed, and this drug is not removed through hemodialysis or peritoneal dialysis. It is crucial to consult healthcare professionals immediately for appropriate action in case of any adverse symptoms while taking this drug.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, mucosal pain in mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities associated with cough + fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, disorientation, vision changes, paralysis, urinary issues

Mild side effects

Insomnia, dizziness, headache, tremor, anxiety, depression, psychiatric reactions (hallucinations, paranoia, irritability, delirium, disorientation, attention deficits, nightmares, sleep disorders, suicidal thoughts, etc.), agitation, confusion, visual and auditory disturbances, taste and smell disorders, auditory hallucinations, mania, dysesthesia, hypoesthesia, sensory disturbances, weakness, palpitations, nausea, vomiting, abdominal discomfort, diarrhea, anorexia, abdominal pain, abdominal bloating, indigestion, oral issues

Store this medication in a tightly closed container to protect it from air or moisture. It is best to maintain the storage temperature between 1 degree and 30 degrees Celsius at room temperature.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle