Cardinal Tablet 25mg (Carvedilol)

Adult dose

Do not increase the dose or stop taking this medicine without the instructions of a physician. 1. Essential hypertension 1) Adults (1) For the first 2 days, administer 12.5 mg of carvedilol orally once a day, followed by 25 mg orally once a day. (2) The usual dose is 25 mg orally once a day for 2 weeks. If a dose increase is needed, increase to 25 mg twice a day. The maximum dose per administration is 25 mg, and the maximum daily dose is 50 mg. 2) Elderly patients For some elderly patients, 12.5 mg once a day may be sufficient. However, if the effect is inadequate after 2 weeks of treatment, the dose may be increased. 2. Chronic stable angina 1) For the first 2 days, administer 12.5 mg of this medicine twice a day orally, followed by 25 mg twice a day orally. 2) The usual dose is 25 mg twice a day for 2 weeks. If a dose increase is needed (excluding elderly patients), the dose may be increased up to 50 mg twice a day. 3. Congestive heart failure Before starting treatment with this medicine, the standard treatment regimen already being administered (conventional treatment for chronic heart failure, including an ACE inhibitor, a diuretic, and usually a digitalis preparation) must be stable. Fluid retention should also be minimized before starting treatment with this medicine. 1) The usual initial dose is 3.125 mg of this medicine twice a day orally for 2 weeks. If the patient tolerates this treatment well, increase the dose to 6.25 mg twice a day for 2 weeks, then to 12.5 mg twice a day for 2 weeks, and then to 25 mg twice a day. 2) Increase the dose gradually after taking each dose level for at least 2 weeks, up to the dose tolerated by the patient. 3) The minimum effective dose is 6.25 mg twice a day. The maximum dose is 25 mg twice a day for patients weighing 85 kg or less and 50 mg twice a day for patients weighing more than 85 kg. 4) To control the rate of absorption, it is recommended to take this medicine with meals in the morning and evening. Taking this medicine with food slows the rate of absorption and may reduce the incidence of orthostatic hypotension.

This medication should not be administered to certain patients. For example, it should not be used in those who are allergic to this medication or its components, those experiencing cardiogenic shock, those with severe cardiac conduction disturbances, patients with pulmonary heart disease, individuals with diabetic ketoacidosis, patients with severely weakened heart function, patients with respiratory conditions such as asthma or chronic obstructive pulmonary disease, and women who are pregnant or breastfeeding. Additionally, caution should be exercised when administering this medication to diabetic patients, those with a history of severe allergies, hypotensive patients, patients with severely impaired renal or liver function, and the elderly, as this drug can lower heart rate or blood pressure, which could exacerbate these conditions. During treatment, symptoms such as dizziness, fatigue, and headache may occur, and in severe cases, heart rate may slow significantly or heart failure may worsen. Allergic reactions such as liver dysfunction or skin rashes may also occur, necessitating caution. Regular monitoring of heart function, blood pressure, and electrocardiograms is required for long-term use. Abruptly discontinuing the medication can worsen cardiac symptoms, so the dosage should be gradually reduced according to a doctor’s instructions. There may be interactions when taken with other medications, particularly antihypertensives, antidepressants, calcium channel blockers, and insulin, so caution is advised. It is also recommended to avoid alcohol consumption. Women who are pregnant or breastfeeding should refrain from using this medication, and its safety in children or adolescents has not been established. In the case of overdose, serious symptoms such as hypotension, bradycardia, and decreased heart function may occur, so it is essential to inform healthcare professionals immediately and seek appropriate treatment. When storing this medication, it must be kept in a light-resistant container to avoid exposure to light, and should be stored out of reach of children.

Dizziness, headache, fatigue, weakness, hallucinations, confusion, depression, sleep disturbances, nightmares, psychosis, severe bradycardia, shock, complete atrioventricular block, heart failure, cardiac arrest, significant hypotension, loss of consciousness, decreased pulse rate, cold limbs, edema, worsening heart failure, cardiac arrest, worsening renal function, renal failure, increased resistance in the respiratory tract, nausea, diarrhea, abdominal pain, vomiting, constipation, urticaria, itching, lichenoid drug eruption, sweating, allergic rash, changes in serum aminotransferases, thrombocytopenia, leukopenia, latent diabetes mellitus onset, hypotension, shortness of breath, hypertension in angina, liver dysfunction, jaundice, limb pain, decreased tears, sensory disturbances, visual disturbances, eye irritation, dry mouth, urinary disorders, sexual dysfunction, allergic reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, marked hypotension, bradycardia, myocardial weakness, cardiac arrest, cardiogenic shock, respiratory distress, bronchospasm, vomiting, consciousness disturbances, generalized seizures

This medication is sensitive to light and should be stored in a light-resistant container. Additionally, to maintain the drug’s efficacy, it should be stored at room temperature, specifically between 1 degree and 30 degrees Celsius.

Appearance

White round tablet

Package unit

100 tablets - 10 tablets/Blister [X 10]