Clarithin Tablet 250mg (Clarithromycin)

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections: Administer this medicine 500mg (potency) twice daily. In this case, it must be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcer: Administer this medicine 500mg (potency) three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

○ Children 12 years of age and older: Same as adults. ○ For children under 12 years of age, use clarithromycin dry syrup.

This drug should not be used in patients with a known allergy to specific components. Patients with a history of allergy to antibiotics with similar structures should also avoid it. Patients currently taking certain medications that may cause cardiac irregularities should not use this drug simultaneously. It should be avoided in patients with severe heart disease or severely impaired liver or kidney function. Pregnant or breastfeeding women should not use this drug. It is also not safe for patients with central nervous system infections. This drug contains lactose, so it should not be taken by patients with lactose intolerance. Patients with impaired liver function need careful dosage adjustments and monitoring. Those with decreased kidney function should also use it cautiously as the drug concentration in the blood may increase. Elderly patients or those with heart disease should be aware of the higher risk of side effects. Careful consultation with a professional is advised when combining with other antibiotics or specific medications due to the potential for increased side effects. Patients should immediately inform healthcare providers of any allergic reactions, gastrointestinal disturbances, skin abnormalities, liver dysfunction symptoms, kidney dysfunction symptoms, or central nervous system abnormalities while taking this drug. Long-term use or high doses may lead to hearing loss or tinnitus, hence careful monitoring is necessary. When combined with anticoagulants, cardiac medications, or diabetes medications, blood concentration changes may occur, requiring regular check-ups. This medication may cause dizziness or confusion during driving or machinery operation, so caution is advised. In case of overdose, gastrointestinal disturbances or central nervous system abnormalities may occur, so the prescribed dosage must be strictly followed. Store it away from direct sunlight and at room temperature; refrigeration is not recommended.

Shok, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, dry mouth, tooth discoloration, pancreatitis, increased amylase, dysgeusia, appetite loss, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic pulmonary infiltrate, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, taste loss, smell loss, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, increased LDH, elevated ALP, increased total bilirubin, increased serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste disturbance, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing impairment, vomiting, purpuric rash, acute generalized exanthematous pustulosis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic-like reaction, vascular edema, appetite loss, decreased appetite, hypoglycemia, insomnia, anxiety, irritability, noise sensitivity, psychotic disorder, confusional state, depersonalization, depression, disorientation, hallucination, abnormal dreams, mania, dysgeusia, headache, loss of consciousness, movement disorders, non-vertiginous dizziness, drowsiness, tremors, convulsions, taste loss, abnormal olfaction, loss of smell, vestibular dizziness, auditory impairment, hearing loss, cardiac arrest, atrial fibrillation, ECG QT prolongation, extrasystole, palpitations, vasodilation, asthma, nasal bleeding, pulmonary embolism, diarrhea, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distension, constipation, dry mouth, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, rash, hyperhidrosis, vesicular dermatitis, itching, hives, papular rash, acne, Henoch-Schonlein purpura, muscle spasms, musculoskeletal rigidity, myalgia, rhabdomyolysis, myopathy, increased serum creatinine, elevated blood urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, malaise, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine color abnormality

This drug may be sensitive to air and moisture, so it must be stored in a tightly closed container. The recommended storage temperature is between 1 to 30 degrees Celsius at room temperature. This helps maintain the effectiveness of the medication.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle