Sponex Capsule (Itraconazole)

Adult dose

(Tablets)(Capsules) It is preferable to administer immediately after a meal. Vulvovaginal candidiasis: Administer itraconazole 200 mg twice a day (morning and evening) for 1 day, or 200 mg once a day for 3 days. Pityriasis versicolor: Administer 200 mg once a day for 7 days. Tinea corporis, tinea cruris: Administer 100 mg once a day for 15 days. Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100 mg once a day for 15 days. Tinea manuum (palms), tinea pedis (soles): Administer 100 mg once a day for 30 days, or 200 mg twice a day for 7 days. Oropharyngeal candidiasis: Administer 100 mg once a day for 15 days. Fungal keratitis: Administer 200 mg once a day for 21 days. Onychomycosis, pulse therapy: Administer 200 mg twice a day for 1 week, followed by a drug-free period of 3 weeks; this constitutes 1 cycle. Administer up to 2 cycles if only fingernails are infected and up to 3 cycles if toenails are infected. Onychomycosis, continuous therapy: Administer 200 mg once a day for 3 months. Systemic fungal infections: In patients with impaired immune function, double the dose if necessary. Aspergillosis: 200mg once a day for 2～5 months. For invasive or disseminated disease, increase the dose to 200mg twice a day. Candidiasis: 100～200mg once a day for 3 weeks～7 months. Cryptococcal meningitis: 200mg twice a day for 2 months～1 year. Maintenance therapy: 200mg once a day. Paracoccidioidomycosis: 100mg once a day for 6 months. (Oral solution) Do not administer with food. Hold this medicine in the mouth for about 20 seconds to ensure that it contacts the entire oral cavity, then swallow. After swallowing, do not rinse the mouth so that the medicine remains in the mouth for a longer time. Oral or esophageal candidiasis: Take 200 mg (20 mL) per day in 1～2 divided doses for 1 week. If there is no effect after 1 week, continue for 1 more week. Fluconazole-resistant oral or esophageal candidiasis: Take 200～400 mg (20～40 mL) per day in 1～2 divided doses for 2 weeks. If there is no effect after 2 weeks, continue for 2 more weeks. Even if symptoms do not improve, do not use 400 mg per day for more than 14 days.

Child dose

Prevention of fungal infections: Administer 5 mg/kg of body weight per day in 2 divided doses.

This medication should not be used in patients with impaired heart function or those with a history of congestive heart failure unless specifically indicated for infection treatment. If signs of heart failure occur during medication administration, use should be discontinued immediately. Patients with allergies or hypersensitivity reactions to this medication or its components should not use it. This medication may interact with other drugs, particularly those related to cardiac conditions, analgesics, and anticoagulants; therefore, extreme caution should be exercised when using them together, and it must not be taken with contraindicated medications. Women who are pregnant or may become pregnant, as well as those who are breastfeeding, should not take this medication. Patients with impaired liver or kidney function may be affected by the metabolism and excretion of this medication; therefore, regular liver function tests and kidney function assessments should be conducted, and dosage adjustments may be necessary when needed. This medication may rarely cause severe side effects such as hepatotoxicity, neuropathy, hearing loss, or cardiac complications; therefore, immediate consultation with healthcare personnel is required if abnormal symptoms appear. Dizziness, drowsiness, or visual or auditory disturbances may occur while taking this medication; caution is advised when driving or operating machinery. Absorption is poor in conditions of low gastric acidity, so if taken with acid-reducing medications, it is advised to take it with acidic beverages. In cases of overdose, there is no specific antidote, and symptomatic treatment is required; the drug is not removed by dialysis. The safety and efficacy of this medication have not been adequately established in children or the elderly, so it should be used cautiously.

Decreased myocardial contractility, heart failure, headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory infection, leukopenia, hypersensitivity, taste disturbance, sensory impairment, sensory abnormality, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, frequency of urination, erectile dysfunction, menstrual disorder, edema, granulocytopenia, thrombocytopenia, anaphylactic-like reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, altered mental state, peripheral neuropathy, dizziness, drowsiness, tremor, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, voice disorders, cough, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, kidney disorders, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, increased alanine aminotransferase, increased aspartate aminotransferase, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased serum urea, increased gamma-glutamyl transpeptidase, increased liver enzymes, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, hearing loss, ventricular ectopic beats, atrial block, palpitations, increased intestinal motility, belching, glossitis, stomatitis, abdominal pain in the lumbar region, pancreatitis, elevated serum total protein, elevated total bilirubin, elevated LAP, decreased appetite, fatigue, dark urine, increased liver enzyme levels, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, alopecia, photosensitivity, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urine protein test, positive urine glucose test, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, elevated serum triglyceride levels, flushing, elevated serum uric acid levels, elevated serum potassium levels, serum sickness, angioedema, anaphylactic reaction, hyperlipidemia, tremor, visual impairment, transient hearing loss, permanent hearing loss, congestive heart failure, dyspnea, significant hepatotoxicity, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, increased serum creatine phosphokinase

This medication should be stored in a tightly sealed container to prevent air or moisture ingress. The ideal storage temperature is between 1 degree and 30 degrees Celsius. This helps maintain the efficacy of the medication for an extended period.

Appearance

A hard capsule with a blue upper part and pink lower part filled with white or yellowish pellets

Package unit

30 capsules/bottle, 200 capsules/bottle