PeriPlus 2.5% Solution

Adult dosage

Typically for adults, 1.5 to 2.5L is administered intraperitoneally per session, retaining for 4 to 8 hours before draining, with procedures repeated 3 to 5 times daily. The physician must adjust the treatment method, frequency, exchange volume, dialysis time, and duration according to the patient's symptoms. This solution is used for dialysis treatment and the dosage varies according to body constitution, with exchange frequency adjusted based on biochemical and volume control.

This medication is used in peritoneal dialysis treatment and abrupt discontinuation can pose a risk to life. Caution is required as certain patients should not use this drug, such as those with diaphragmatic perforation, severe abdominal burns, severe peritoneal adhesion, or at risk of bleeding. Patients with lactic acidosis, severe electrolyte abnormalities, those who have recently undergone abdominal surgery, inflammatory bowel disease patients, patients with tumors or hernias in the abdomen, severe lung diseases, or septic patients need careful evaluation before use. Patients with inadequate protein intake or significant weight loss, or those who cannot follow treatment instructions from their physician, also require caution. When using this drug, patients taking digitalis preparations should frequently check serum potassium levels, and patients suspected of having glucose metabolism disorders should regularly test blood sugar. Other considerations include those with lumbar disorders, patients with ostomy use, diuretic users, severe ventilation disorders, obesity, steroid users, immunocompromised patients, antibiotic allergies, pregnant or nursing individuals, patients with peritonitis, and patients with hyperparathyroidism. While using this medication, adverse reactions such as abdominal pain, bleeding, peritonitis, inflammation, or catheter issues may occur. Gastrointestinal symptoms may include nausea, abdominal pain, diarrhea, constipation, hemorrhoids, vomiting, lack of appetite, abdominal bloating, bowel obstruction, hypokalemia, hyponatremia, hypocalcemia, hypophosphatemia, hyperlactatemia, hypomagnesemia, hypercholesterolemia, hypertriglyceridemia, metabolic acidosis, and others. There is a risk of infection or sepsis occurring during the peritoneal dialysis process, so aseptic handling in a clean environment is essential. Accurate confirmation of the dialysis solution's composition, careful observation of body weight and fluid status, and possible nutritional supplementation of proteins and vitamins may be necessary. Diabetics should frequently monitor their blood sugar and adjust insulin dosages. Early discontinuation of peritoneal dialysis can lead to fluid overload and uremia. This medication can affect the blood concentrations of other drugs during dialysis, necessitating dosage adjustments as needed, and caution is required when using with calcium or vitamin D-containing drugs to avoid hypercalcemia. The safety of this medication has not been established for pregnant or nursing women; it should only be used when the therapeutic benefits outweigh the risks. In children, the dosage of the dialysis solution should be adjusted according to weight and age, and in elderly patients, the risk of hernia should be considered. In case of overdose, dehydration, electrolyte abnormalities, and hyperglycemia may occur, requiring immediate medical attention. The peritoneal dialysis solution should only be used if the provided container has not been opened; the medication should not be used if the packaging is damaged or if the solution appears cloudy. It is intended for intraperitoneal dialysis only. Always check the state of the container before use, and the dialysis solution should be warmed to body temperature before administration. Any unused dialysis solution should be discarded, and when adding medications, it should be done aseptically and quickly.

Serious side effects

Peritonitis (accompanied by severe fever), sepsis, respiratory distress due to diaphragmatic defects, bowel obstruction, severe edema, elevated blood pressure, potential for severe allergic reactions, respiratory problems due to pulmonary edema.

Mild side effects

Abdominal pain, bleeding, peritonitis (abdominal pain, cloudy effluent, fever), inflammation around the abdominal catheter (redness, discharge), catheter breakage, subcutaneous inflammation at the draining site, nausea, abdominal pain, diarrhea, constipation, hemorrhoids, vomiting, lack of appetite, abdominal distension, bowel obstruction, hypokalemia, hyponatremia, hypocalcemia, hypophosphatemia, hyperlactatemia, hypomagnesemia, hypercholesterolemia, hypertriglyceridemia, metabolic acidosis, and low.

Store this medication in a sealed container to prevent air or moisture ingress; do not freeze, and keep in a cool place below 25 degrees Celsius. This storage method will safely maintain the medication's efficacy.

Appearance

This medicine is a transparent peritoneal dialysis solution that is light yellow and contained within a plastic bag with two chambers, clear and colorless.

Package unit

2L/bag (Note: A solution:B solution = 725:1275)