Roxithromycin Tablet (Roxithromycin)

Adult dose

Adults: The usual dose is 150 mg (potency) of roxithromycin orally twice daily, in the morning and evening before meals. For pneumonia, administer 300 mg (potency) once daily before breakfast. The dose may be adjusted according to age and symptoms.

Child dose

Children: The average dose used in clinical trials was 6 mg (potency) per kg of body weight per day. Administer 5–8 mg (potency) per kg of body weight per day orally in 2 divided doses. Children weighing 6–11 Kg: Take 25 mg (potency) per dose twice daily before meals (for pediatric tablets and granules only), or take 2.5mL per dose twice daily before meals (for suspension only). Children weighing 12–23Kg: Take 50mg (potency) per dose twice daily before meals (for pediatric tablets and granules only), or take 5mL per dose twice daily before meals (for suspension only). Children weighing 24～40Kg: Take 100mg (potency) per dose twice daily before meals (for pediatric tablets and granules only), or take 10mL per dose twice daily before meals (for suspension only).

This medication can rarely cause serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis. If symptoms such as blistering of the skin or mucosal damage occur, discontinue use immediately. Patients allergic to this drug or to macrolide antibiotics, those taking certain cardiac medications (terfenadine, astemizole, cisapride, pimocard), ergot alkaloids, or mizolastine should not use this medication. Patients with impaired liver function or elderly patients should use this medication with caution, and when used with other antibiotics, be aware of resistance issues. This medication can prolong the QT interval of cardiac electrical signals, so patients with congenital long QT syndrome or at risk of arrhythmias, or those taking certain antiarrhythmic medications should be particularly cautious. Patients with myasthenia gravis may experience exacerbation of symptoms due to this medication, requiring careful monitoring. This medication can rarely cause severe allergic reactions such as anaphylactic shock, so if symptoms appear, discontinue use immediately and seek appropriate treatment. Adverse effects may include liver function abnormalities, gastrointestinal issues (nausea, vomiting, diarrhea, abdominal pain, etc.), severe colitis, pneumonia, neurological symptoms (headache, dizziness, drowsiness), alterations in taste and smell, and skin rashes. Consult healthcare professionals if abnormal symptoms occur. Use of this medication may lead to infections due to a reduction in beneficial intestinal bacteria, so symptoms should be monitored closely. Strict adherence to dosing is required for children, as overdose may affect bone growth. This medication has many interactions with other drugs, especially cardiac medications, anticoagulants, immunosuppressants, sedatives, and heart medications, so caution is necessary when taken together. Women who are pregnant or may become pregnant should carefully consider the risks and benefits before using this medication, and breastfeeding mothers should avoid using it or discontinue breastfeeding. Elderly patients may experience prolonged half-life of the drug in the body, but general dose adjustments are not required. This medication may cause dizziness or vision disturbances, so caution is required when driving or operating machinery. Finally, this medication should be stored out of the reach of children and not transferred to other containers for safety.

Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, shock, fever, rash, allergic skin reactions, angioedema, eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, cholestatic acute hepatitis, hepatocellular acute hepatitis, jaundice, elevated AST, elevated ALT, elevated ALP, elevated serum bilirubin, loss of appetite, nausea, vomiting, epigastric discomfort, abdominal pain, abdominal cramps, diarrhea, membranous colitis, loose stools, hemorrhagic colitis, blood in stool, pancreatitis, bronchospasm, cough, dyspnea, abnormal chest X-ray, interstitial pneumonia, drowsiness, headache, dizziness, tongue numbness, paralysis, taste disturbance, ageusia, smell disturbance, anosmia, erythema multiforme, purpura, superinfection due to overgrowth of non-susceptible pathogens, transient hearing loss, auditory impairment, visual impairment, blurred vision, ocular congestion, general malaise, weakness, palpitations, QT prolongation, ventricular tachycardia, arthralgia, epistaxis, menstrual irregularities, inflammation of oral and vaginal mucosa, hallucinations, confusion

This medication should be stored in a tightly sealed container to prevent air exposure and kept at room temperature that is neither too hot nor too cold. Storing it this way can maintain the drug's effectiveness for a longer period.

Appearance

Biconvex white round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle