Oxygreen Capsule 20 mg (Fluoxetine Hydrochloride)

Adult dosage

Adults 1. Depression 1) Initial treatment: The initial dose is fluoxetine hydrochloride 20mg orally once daily in the morning. In controlled clinical trials, doses of 20～80mg daily were administered. If no improvement is observed, a dose increase may be considered after several weeks. Doses exceeding 20mg daily should be administered in 2 divided doses (morning and noon), and the maximum dose of 80mg daily should not be exceeded. The onset of an adequate antidepressant effect may be delayed until 4 weeks or longer after starting treatment. 2) Maintenance/continuation/extended treatment: There are no definitive data on how long patients should be treated with this medicine; however, psychopharmacologists recognize that acute episodes of depression require several months or longer of drug treatment. It is not known whether the amount of antidepressant needed to relieve symptoms is the same as that needed to maintain or sustain remission. 2. Bulimia nervosa Administer 60mg of this medicine daily. The daily dose should not exceed 80mg. Measure electrolyte concentrations before starting treatment. 3. Obsessive-compulsive disorder Administer 20～60mg of this medicine daily. The daily dose should not exceed 80mg. 4. Premenstrual dysphoric disorder Administer 20mg of this medicine daily. Reassess whether continued treatment is necessary after 6 months of treatment. Patients with renal and/or hepatic impairment, patients receiving multiple medicines, elderly patients, and patients with comorbid conditions: Administer a low dose or reduce the frequency of administration. Adjust the dose appropriately according to age and symptoms. Switching from or to MAO inhibitors for the treatment of psychiatric disorders When discontinuing an MAO inhibitor used to treat psychiatric disorders and starting treatment with this medicine, allow an interval of at least 14 days. Conversely, at least 5 weeks must elapse after discontinuing this medicine before starting an MAO inhibitor for the treatment of psychiatric disorders. Other MAO inhibitors, such as linezolid or methylene blue Patients receiving linezolid or intravenous methylene blue should not start treatment with this medicine because of the increased risk of serotonin syndrome. In patients who require more urgent treatment for a psychiatric condition, including hospitalization or other interventions, treatment should be considered. It may be necessary to urgently administer linezolid or intravenous methylene blue to a patient already receiving this medicine. If no alternative to linezolid or intravenous methylene blue is available and, for a particular patient, the benefits of treatment with linezolid or intravenous methylene blue are judged to outweigh the risk of serotonin syndrome, this medicine may be stopped immediately and linezolid or intravenous methylene blue administered. Monitor the patient for symptoms of serotonin syndrome for 5 weeks after administration of linezolid or intravenous methylene blue, or until 24 hours after the last dose, whichever occurs first. Treatment with this medicine may be resumed 24 hours after the last dose of linezolid or intravenous methylene blue. The risk associated with administration of methylene blue by a non-intravenous route (oral tablets or local injection), or with intravenous administration of this medicine at a dose of 1mg/kg or less, is unclear. Nevertheless, clinicians should be aware of the possibility of emergency symptoms of serotonin syndrome with these uses.

This medication is used to treat psychiatric conditions such as depression and caution is especially needed in children and adolescents, as its use is not approved in these populations. This drug may increase the risk of suicidal thoughts or behaviors, especially in young adults aged 18 to 24, so caution is advised when prescribing it to this demographic. All patients taking this medication should be closely monitored for suicidal tendencies or changes in behavior during the initial treatment period and when changing dosages, and family members and caregivers should also keep a close watch on the patient. This drug should not be used in specific patients, such as those with allergies to this medication or its components, patients with severe renal impairment, and patients currently taking MAO inhibitors. Caution is required when prescribing this medication to patients with a history of seizures; treatment should be discontinued immediately if seizures occur or their frequency increases. This medication should also be used with caution in patients with a history of mania or hypomania and should be stopped if symptoms arise. Patients with heart disease or at risk of QT interval prolongation must have an ECG prior to taking this drug and their heart condition closely monitored during treatment. Patients with impaired liver or kidney function may need dosage adjustments or cautious use. Diabetic patients should monitor their blood sugar levels closely, as changes in blood sugar control may occur during treatment. Rarely, this medication can cause dilation of pupils, necessitating caution in patients at risk for increased intraocular pressure or acute glaucoma. Common side effects of this drug include headache, nausea, insomnia, fatigue, and diarrhea, while allergic reactions or severe skin reactions may occur infrequently. Withdrawal symptoms such as dizziness, sensory disturbances, sleep disorders, anxiety, nausea, trembling can occur upon discontinuation, so dosing should be tapered off gradually. This drug may interact with other medications, so patients should inform their doctor or pharmacist of any other medications they are taking. Particularly, the concurrent use with MAO inhibitors can lead to life-threatening serotonin syndrome, and such combinations should be avoided. During pregnancy, the risks to the fetus and the benefits of this medication should be carefully weighed, and caution is needed during breastfeeding as the drug can be excreted in breast milk. The safety of this drug in children and adolescents has not been established; thus, avoidance of use is recommended if possible. Elderly patients might experience adverse effects from this medication, thus requiring careful monitoring. Overdose can lead to symptoms such as nausea, vomiting, seizures, heart arrhythmias, and coma, and immediate medical attention must be sought. This drug should be stored out of the reach of children and should not be transferred to other containers. Patients should be careful while driving or operating dangerous machinery during treatment and are advised to avoid alcohol consumption.

Headache, nausea, insomnia, fatigue, diarrhea, anaphylactic reaction, serum sickness, abnormal secretion of antidiuretic hormone, appetite decrease, hyponatremia, anxiety, nervousness, restlessness, tension, decreased libido, sleep disorder, abnormal dreams, depersonalization, elevated mood, happy mood, thought disorder, abnormal libido, bruxism, hypomania, mania, hallucinations, agitation, panic attacks, suicidal thoughts and behaviors, confusion, attention disorder, dizziness, taste disorder, hypersomnia, drowsiness, tremors, psychomotor agitation, movement disorders, ataxia, balance disorder, tonic-clonic seizures, spasms, inability to sit still, Buccoglossal syndrome, serotonin syndrome, memory impairment, blurred vision, pupil dilation, palpitations, ventricular arrhythmia, QT prolongation, flushing, hypotension, vasculitis, vasodilation, yawning, dyspnea, pharyngitis, incidents related to the lungs, nosebleed, vomiting, dyspepsia, dry mouth, dysphagia, esophageal pain, gastrointestinal bleeding, specific hepatitis, rash, urticaria, pruritus, hyperhidrosis, alopecia, increased tendency to bruise, cold sweats, angioedema, petechiae, photosensitivity reaction, purpura, erythema multiforme, arthralgia, myoclonus, myalgia, increased urination, dysuria, urinary retention, urination disorders, gynecological bleeding, erectile dysfunction, ejaculatory dysfunction, sexual dysfunction, galactorrhea, hyperprolactinemia, priapism, anxious mood, chills, malaise, abnormal mood, feeling cold, feeling hot, mucosal bleeding, weight loss, abnormal liver function tests, suicidal ideation, suicidal behavior, fractures, dizziness, sensory disturbances, sleep disorders, asthenia, agitation, anxiety, tremors, headache, anaphylactoid reaction, progressive systemic reaction, severe skin, kidney, liver, or lung-related reactions, growth delay, delayed puberty, Stevens-Johnson syndrome, toxic epidermal necrolysis, changes in platelet function, aplastic anemia, atrial fibrillation, cataract, cerebrovascular accident, cholestatic jaundice, movement disorders, eosinophilic pneumonia, epithelial necrosis, nodular erythema, exfoliative dermatitis, gynecomastia, cardiac arrest, liver failure, necrosis, hypoglycemia, immune-related hemolytic anemia, renal failure, exacerbation of movement disorders, optic neuritis, pancreatitis, pancytopenia, pulmonary embolism, pulmonary hypertension, thrombocytopenia, thrombocytopenic purpura, ventricular tachycardia, vaginal bleeding, aggressive behavior, akathisia, panic disorder, excitement, hostility, aggression, impulsivity, insomnia, agitation, hallucinations, delirium, coma, tachycardia, unstable blood pressure, sweating, fever, festination, tonic-clonic seizures, petechiae, gastrointestinal symptoms, vomiting, diarrhea, bleeding, postpartum hemorrhage, petechiae, purpura, skin abnormal bleeding, vaginal bleeding, gastrointestinal bleeding, progressive systemic reaction, thrombocytopenia, thrombocytopenic purpura, ventricular tachycardia, persistent crying, muscle tone decrease, tremors, hypersensitivity, difficulty sucking or sleeping

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is best to maintain the storage temperature between 1 to 30 degrees Celsius. Storing it this way ensures the drug's effectiveness and safety are well maintained.

Appearance

A hard capsule with a green upper part and a pale yellow lower part, filled with a white to grayish powder.

Package unit

30 capsules/bottle, 300 capsules/bottle