Reposin Injection (Levofloxacin)

Adult administration

Administered as a drip intravenous infusion 1-2 times daily. The dose is determined based on the type of infection, severity of infection, and sensitivity of the suspected causative organism. In general, after intravenous administration, patients may be switched to oral formulation based on their status, and the oral dose is the same as the intravenous dose. The administration is only via drip intravenous infusion, and can be given 1-2 times daily for a maximum of 14 days. The infusion time should take at least 60 minutes. Normal renal

This medication carries the risk of causing tendon-related disorders such as tendonitis or tendon rupture, so if these symptoms appear, use should be discontinued immediately. Peripheral neuropathy or central nervous system disturbances may also occur, necessitating caution if neurological abnormalities arise. This medication should not be used in patients with myasthenia gravis, as it may worsen symptoms. It should be used under limited circumstances for specific infections such as acute bacterial rhinosinusitis, acute exacerbations of chronic bronchitis, uncomplicated urinary tract infections, and acute otitis media. When administered via injection, it should be administered slowly according to the rate of intravenous infusion, and if blood pressure drops suddenly during administration, it should be stopped immediately. Elderly patients, those with renal impairment, patients on high doses, and those taking corticosteroids should avoid concomitant use and be monitored closely due to an increased risk of tendon rupture. This medication can provoke seizures; therefore, caution is required in patients with a history of epilepsy or central nervous system disorders. Hypersensitivity or severe allergic reactions may occur; if symptoms such as skin rash, itching, or difficulty breathing occur, use should be discontinued immediately. Gastrointestinal disturbances like nausea, diarrhea, and abdominal pain may occur, so caution is necessary if symptoms develop. Neuropsychiatric symptoms like headaches, dizziness, insomnia, and occasionally hallucinations or confusions may present, and abnormal symptoms should be reported. Cardiovascular side effects such as tachycardia, hypotension, and, rarely, arrhythmias, require caution in patients with heart disease. Musculoskeletal issues such as arthralgia, myalgia, tendonitis, and tendon rupture, particularly Achilles tendon rupture, should be monitored. It may affect liver and kidney function, necessitating monitoring if liver enzyme levels are elevated or signs of renal impairment occur. Blood disorders may appear, so immediate notification is required for symptoms such as leukopenia or thrombocytopenia. It may cause photosensitivity reactions, so strong sunlight or ultraviolet exposure should be avoided, and use should be discontinued if skin abnormalities appear. Dizziness or drowsiness may occur during driving or operating machinery, necessitating caution. To prevent the emergence of resistant organisms, it is important to administer the drug only for the necessary duration after susceptibility testing. It should not be used in pregnant women or those who may become pregnant, nursing mothers, or growing children and adolescents. Due to drug interactions, it is essential to consult with a doctor or pharmacist when taking other medications, especially blood glucose-lowering agents, anticoagulants, and steroids. In cases of overdose, central nervous system symptoms and arrhythmias may appear, requiring immediate emergency treatment. This medication should be stored under appropriate conditions, and should be used as soon as possible after opening.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucous membranes, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanied by cough and fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and severe headaches, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis,

Mild side effects

• Itching
• rash
• nausea
• diarrhea
• loss of appetite
• vomiting
• abdominal pain
• dyspepsia
• abdominal distension
• constipation

This medication should be stored in a sealed container to prevent air intrusion, at room temperature between 1 and 30 degrees Celsius. Additionally, it should be stored in a dark place to avoid direct sunlight.

Appearance

A vial containing a transparent liquid with a pale greenish-yellow color

Package unit

50 mL/vial X 1, 100 mL/vial X 1, 150 mL/vial X 1