Withers Levofloxacin Tablet 100 mg (Levofloxacin Hemihydrate)

Adult dose

Typically for adults, Levofloxacin is administered orally at a dose of 100 mg, 2-3 times daily. In cases of severe or insufficient effect, it is administered at a dose of 200 mg, 3 times daily. Adjustments are made according to age and symptoms.

This drug is a fluoroquinolone antibiotic used for the treatment of various bacterial infections. However, it can cause serious side effects such as tendinitis or tendon rupture, peripheral neuropathy, central nervous system disturbances, and exacerbation of myasthenia gravis. If these side effects occur, use should be discontinued immediately and it should not be administered to patients with myasthenia gravis. This drug is limited to the use of acute bacterial non-sinusitis, acute bacterial exacerbation of chronic bronchitis and chronic obstructive pulmonary disease, uncomplicated urinary infections, acute otitis media, and it should only be administered when no other treatment options are available. Especially in elderly patients, patients with decreased kidney function, solid organ transplant recipients, and those using corticosteroids in combination, there is an increased risk of tendon rupture, so co-administration should be avoided; if symptoms of pain, inflammation, or tendon rupture appear, treatment should be stopped and rest should be taken. This drug may exacerbate symptoms in patients with myasthenia gravis and can carry a risk of seizures, thus it should be administered with caution in patients with epilepsy or central nervous system disorders. Moreover, it should not be administered to patients with a history of hypersensitivity to this drug or similar drugs, patients under 18 years of age who are still growing, pregnant or breastfeeding women, patients with epilepsy, and patients with certain genetic lactose intolerance. During administration, careful monitoring of blood, liver, kidney function abnormalities, cardiac rhythm abnormalities, severe skin reactions, gastrointestinal disturbances, and neurological symptoms should be conducted, and if any abnormal symptoms appear, administration should be discontinued immediately. This drug may interact with other medications, particularly when co-administered with non-steroidal anti-inflammatory drugs, warfarin, theophylline, antacids, and iron preparations, so caution is needed. It should not be used during pregnancy or while breastfeeding, nor should it be administered to children and adolescents in growth stages. In elderly patients, renal function decline can increase drug concentration, so dosing and administration intervals should be adjusted and used with caution. In case of overdose, central nervous system symptoms and cardiovascular effects may appear, so immediate medical attention should be sought; this drug is not eliminated by dialysis. While taking this drug, caution should be taken to avoid excessive exposure to sunlight or artificial ultraviolet light, and care should be taken while driving or operating machinery as dizziness or drowsiness may occur.

Serious side effects

• Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor → severe allergic reaction
• Severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain → severe skin abnormal reaction
• Shortness of breath or difficulty breathing, asthma attacks, breathing abnormalities with cough+fever → respiratory issues
• Skin or eyes turning yellow (jaundice), extreme lethargy → liver issues (jaundice)

Mild side effects

• Nausea
• diarrhea
• vulvovaginitis
• insomnia
• abdominal pain
• bloating
• itching
• dizziness
• rash
• dyspepsia

This drug can be sensitive to air and moisture, so it should be kept in a tightly sealed container. The storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius. Proper storage can help maintain the drug's effectiveness for a longer duration.

Appearance

White to off-white round film-coated tablet

Package unit

30 tablets/bottle, 500 tablets/bottle