Rex Tablet 2mg (Glimepiride)

Adult dose

Patients who have not previously received medication should start with a dose of 1 mg of glimepiride once a day. If necessary, the dose may be increased by 1 mg at intervals of 1 to 2 weeks. Generally, there is little additional effect beyond the dose of 4 mg, although some patients may increase the dose up to 6 mg (or 8 mg). If a dose of 4 mg per day fails, consider switching to insulin therapy.

This medicine is not to be used in patients with insulin-dependent diabetes or those in diabetic ketoacidosis or coma. Additionally, it should not be administered to patients who have had allergic reactions to this drug, sulfonylureas, or sulfonamides. It is contraindicated in patients with severely impaired liver or kidney function, and in such cases, switching to insulin therapy is recommended. Women who are pregnant or of childbearing potential, as well as breastfeeding women, should not take this medication. Insulin therapy is also recommended for patients with severe infections, pre and post-operative patients, and those with severe trauma. Patients with gastrointestinal disorders like diarrhea or vomiting are at increased risk of hypoglycemia and should be monitored closely. This medication contains lactose, and it should not be administered to patients with lactose intolerance or related genetic disorders. During the first week, there is a high risk of hypoglycemia, so careful monitoring of blood sugar is essential, particularly for patients with poor nutritional status, irregular eating habits, the elderly, those with compromised kidney or liver function, or those taking other medications. Symptoms of hypoglycemia can include headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and loss of consciousness, so immediate sugar intake is necessary if these symptoms occur. Visual disturbances, gastrointestinal symptoms, liver function abnormalities, blood abnormalities, and allergic reactions can occur rarely, so if any unusual symptoms appear, consult medical personnel. It is essential to maintain regular meals, exercise, and weight control while taking this medicine, and consistently monitor diabetes status and drug effectiveness. Especially when taking other medications, interactions can occur, so be sure to inform your physician or pharmacist of all medications being taken. In cases of overdose, severe hypoglycemia may occur, requiring immediate emergency treatment and possibly intravenous glucose in a hospital. The safety and efficacy of this medication in children have not been established, and elderly patients may require dose adjustment due to diminished kidney function. Store this medicine out of reach of children and keep it in its original container to prevent degradation.

Serious side effects

Hives, severe swelling (edema). Liver dysfunction and jaundice. Stevens-Johnson syndrome (mucocutaneous reaction). Respiratory distress. Seizures. Severe thrombocytopenia with thrombocytopenic purpura. Anaphylaxis, angioedema. Confusion of consciousness, coma. Coma due to severe hypoglycemia. Serious blood disorders (aplastic anemia, etc.).

Mild side effects

Symptoms of hypoglycemia: headache, severe hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggression, decreased concentration, decreased agility or motivation, depression, confusion, speech impairments, visual disturbances, tremors, incomplete paralysis, sensory disturbances, dizziness, weakness, loss of self-control, transient mental confusion, seizures, drowsiness, loss of consciousness, shallow breathing, bradycardia. Symptoms of adrenergic counterregulation: sweating, cool and moist skin, anxiety, tachycardia.

This medicine should be kept in a tightly sealed container to prevent exposure to air or moisture. It is recommended to maintain a storage temperature between 1 degrees and 30 degrees Celsius. By doing so, the effectiveness of the medicine can be safely preserved.

Appearance

Green oval tablet

Package unit

30 tablets/bottle, 200 tablets/bottle, 500 tablets/bottle