Meticon Tablets (Cimetidine)

Adult dosage

In adults, 400 mg of cimetidine is administered orally twice daily (morning and bedtime) or once daily (at bedtime) as 800 mg. Additionally, 300 mg can be administered orally four times daily (after meals and at bedtime), and the maximum dose can be increased to 400 mg four times daily (after meals and bedtime) (total 1.6 g). For improvement of gastric mucosal lesions due to acute gastritis and acute exacerbation of chronic gastritis, 200 mg can be administered twice daily or 400 mg once daily.

Children's dosage

In children, it is administered orally in divided doses of 20-40 mg per kilogram of body weight per day.

This drug may contain glass fragments when using glass ampoule injections, so extreme caution is required, especially when administering to children or the elderly. Patients with hypersensitivity to any components of this drug or cimetidine, or with a history of such reactions, should not use it. This medication should not be administered to patients taking dofetilide due to the increased risk of cardiac arrhythmias. Patients with impaired renal or hepatic function, a history of drug hypersensitivity, the elderly, children under 19, and patients undergoing hemodialysis should use this medication cautiously, and the dosage may need to be adjusted or the interval prolonged as necessary. This drug can mask symptoms of gastric cancer; therefore, it is important to confirm malignancy before administration. Patients with Helicobacter pylori positive gastric and duodenal ulcers should receive concurrent bacterial eradication treatment. This drug contains specific coloring agents that require caution in patients with allergies to these components. While taking this medication, various side effects, including leukopenia, liver function abnormalities, renal function abnormalities, allergic reactions, gastrointestinal disorders, neurological anomalies, and skin rashes, may occur. If symptoms arise, immediate consultation with medical personnel is required. Elderly patients or those with chronic conditions should be closely monitored for changes in mental state or confusion. This medication may interact with several other drugs, so patients currently taking other medications must inform their healthcare provider, and dosage adjustments may be necessary. Pregnant women or those who may become pregnant should use this medication only when the benefits outweigh the risks, and breastfeeding women should discontinue breastfeeding as it is safer. Safety in children has not been adequately proven; therefore, it should be administered cautiously only when absolutely necessary. Elderly patients often have reduced renal function, which may increase plasma drug concentration, necessitating dosage reduction or increased intervals. Overdose may cause respiratory depression; if symptoms are severe, emergency procedures may include artificial ventilation or gastric lavage. When administered as an injection, a rapid intravenous injection may cause arrhythmias or hypotension, so the infusion should be slow. This drug should be stored out of the reach of children and should not be transferred to other containers. Animal experiments have reported weak anti-androgenic effects and some changes in reproductive organs, but it is known that clinical use has no significant impact on reproductive capacity.

Serious side effects

Shock, anaphylactic-like reactions, respiratory distress, thrombocytopenia, aplastic anemia, immune hemolytic anemia, jaundice, acute renal failure, interstitial nephritis, urinary retention, renal dysfunction, consciousness disturbance, seizures, confusional state, Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermal necrosis, erythema multiforme, exfoliative dermatitis, generalized exfoliative erythema and edema

Mild side effects

• Leukopenia
• granulocytopenia
• agranulocytosis
• thrombocytopenia
• pancytopenia
• general malaise
• weakness
• subcutaneous bleeding
• mucosal bleeding
• fever

This medication should be stored in a tightly sealed container that is air-tight, preferably at a temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the drug's effectiveness for an extended period.

Appearance

Pale green round film-coated tablet

Package unit

30 tablets/bottle, 500 tablets/bottle