Yuyu Lincomycin Injection 300 mg/mL (Lincomycin Hydrochloride)

Adult dosage

(Capsules) ○ Adults: For severe infections, administer lincomycin 500 mg (potency) orally every 8 hours; for very severe infections, administer 500 mg (potency) every 6 hours. For beta-hemolytic streptococcal infections, treatment should preferably continue for at least 10 days to prevent rheumatic fever or glomerulonephritis that may occur as a complication after treatment. Adjust the dose appropriately according to age and symptoms. (Injection) 1. Intramuscular injection ○ Adults: For severe infections, administer lincomycin 300 mg (potency) intramuscularly twice daily; for very severe infections, administer 600 mg (potency) intramuscularly twice daily. 2. Intravenous injection ○ Adults: For severe infections, administer 600 ∼ 1,000 mg (potency) of this medication daily by intravenous infusion in 2 ∼ 3 divided doses; the dose may be increased for very severe infections. Adjust the dose appropriately according to age and symptoms. 3. Method of administration This medication must be diluted before intravenous administration. Normal saline or 5 % dextrose injection may be used as the diluent. The dilution volumes and infusion rates are as follows. Dose (mg) / Diluent volume (mL) / Infusion time (hr) 600 / 100 / 1 1000 / 100 / 1 2000 / 200 / 2 3000 / 300 / 3 4000 / 400 / 4

Children's dosage

○ Children (28 days and older): For severe infections, administer 30 mg (potency)/kg body weight daily in 3 ∼ 4 divided doses; for very severe infections, administer 60 mg (potency)/kg body weight in 3 ∼ 4 divided doses. ○ Children (28 days and older): For severe infections, administer 10 mg (potency)/kg body weight daily by intramuscular injection in 1 ∼ 2 divided doses. ○ Children (28 days and older): For severe infections, administer 10 ∼ 20 mg (potency)/kg body weight daily by intravenous infusion in 2 ∼ 3 divided doses.

This medication should be handled carefully when opening the injection container, as glass fragments may mix in, especially for use by children or elderly individuals. Additionally, this medication may cause severe colitis; it should only be used for severe infections when necessary, and treatment should be stopped immediately if abdominal pain or diarrhea worsens, or according to a doctor's instructions. It should not be used for mild bacterial infections or non-bacterial upper respiratory infections, and it is not suitable for the treatment of meningitis as it does not penetrate well into cerebrospinal fluid. Individuals who are allergic to this drug or similar components, patients with severe colitis or bacterial meningitis, and breastfeeding women should not use this drug. Caution should be exercised for elderly patients or those with liver or kidney issues, as well as individuals with a history of bronchial asthma or severe allergies, and patients with esophageal issues or myasthenia must be administered this drug cautiously. Various side effects may occur during the use of this medication, including shock, severe diarrhea, abdominal pain, skin rash, liver dysfunction, and kidney dysfunction, so symptoms must be reported to healthcare personnel immediately. To prevent antibiotic resistance, it is critical to confirm the sensitivity of the infecting bacteria and to administer the minimum duration necessary, and routine blood and liver-kidney function tests should be conducted with long-term use. Antidiarrheal agents should not be taken together with this drug, and individuals with a history of antibiotic allergies should prepare for emergencies such as anaphylactic shock. This drug carries the risk of respiratory failure or reduced efficacy when used with other specific antibiotics or medications, so it must be discussed with a healthcare professional. It is advisable for pregnant or breastfeeding women to avoid using this drug, and it should not be administered to neonates or premature infants. In case of overdose, symptoms such as abdominal pain, vomiting, or diarrhea may appear, necessitating an immediate visit to a medical facility, and it is advisable to inform practitioners about this drug, as it may affect blood test results. Finally, this drug should be stored out of reach of children and should not be transferred to other containers for safety.

Shock, cyanosis, dyspnea, chest discomfort, hypotension, esophagitis, membranous colitis, diarrhea, loose stools, loss of appetite, nausea, vomiting, abdominal pain, epigastric pain, dry lips, glossitis, stomatitis, anal itching, cardiac arrest, hypotension, fever, cough, dyspnea, abnormal chest X-ray, eosinophilia, interstitial pneumonia, eosinophilic pulmonary infiltrates, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia, pancytopenia, venous thrombosis, tinnitus, dizziness, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, acute generalized exanthematous pustulosis, jaundice, elevated ALT, elevated AST, azotemia, oliguria, proteinuria, generalized flushing, urticaria, rash, angioedema, serum sickness, anaphylaxis, candidiasis, diarrhea due to Clostridium, vaginitis, headache, fatigue

This medication should be stored in a sealed container that prevents air ingress, ideally at room temperature between 1 and 30 degrees Celsius. This will help maintain the medication's effectiveness.

Appearance

A colorless to pale yellow liquid in a colorless, transparent ampoule injection

Package unit

50 ampoules/box [(2 mL/ampoule x 50)]