Seiloxime Tablet 250 milligrams (Sephuroxime Acetil)

Adult dose

For optimal absorption, take after a meal. 1. Adults and children 12 years of age and older 1) Most infections Administer 250mg twice daily. 2) Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by organisms with low susceptibility Administer 500mg twice daily. 3) Urinary tract infections Administer 250mg twice daily. 4) Uncomplicated gonorrhea Administer 1g as a single dose. 5) Lyme disease Administer 500mg twice daily for 14 days (10~21 days). 3. Patients with renal impairment Cefuroxime is excreted primarily by the kidneys. To compensate for delayed excretion in patients with significantly impaired renal function, reduction of the cefuroxime dose as shown below is recommended. Creatinine clearance ≥ 30 mL/min/1.73m2, T1/2 (hours) 1.4 - 2.4: No dose adjustment required (standard dose: 125mg-500mg twice daily) Creatinine clearance 10 - 29 mL/min/1.73m2, T1/2 (hours) 4.6: Administer a standard single dose every 24 hours Creatinine clearance < 10 mL/min/1.73m2, T1/2 (hours) 16.8: Administer a standard single dose every 48 hours Patients on hemodialysis, T1/2 (hours) 2 - 4: Administer an additional standard single dose at the end of each dialysis session For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this drug should be administered for 7~10 days.

Child dose

Infants and children under 12 years of age, most infections: Administer 125mg twice daily. Otitis media in children 2 years of age and older, severe infections: Administer 250mg twice daily. Infants and children under 12 years of age, Lyme disease: Administer 250mg twice daily for 14 days (10~21 days). There is limited experience with use in infants under 3 months of age. This drug must not be divided and is therefore not suitable for treating patients who cannot swallow tablets, such as young infants and children.

This medicine should not be administered to patients with hypersensitivity to cephalosporin antibiotics. Caution should be exercised in patients with a history of allergy to penicillins or other beta-lactam antibiotics. Patients with a predisposition to allergies, such as bronchial asthma or skin reactions like rashes and urticaria, should also be cautious. Patients with severely impaired renal function should be monitored closely before administration. Patients who have difficulty swallowing, elderly patients, or those in poor general health should be observed carefully as symptoms of vitamin K deficiency may occur. Using this medication may lead to mild skin rashes or serious cutaneous reactions such as Stevens-Johnson syndrome, so symptoms should be monitored closely. Gastrointestinal disturbances such as headaches, dizziness, diarrhea, nausea, and abdominal pain may commonly occur, and if symptoms are severe, you should consult a doctor. Blood tests may show abnormalities such as thrombocytopenia or leukopenia, so it is advisable to have regular check-ups. Liver dysfunction or hepatitis and renal function decline may occur, so symptoms or test results should be monitored closely. During antibiotic use, fungi such as Candida may proliferate excessively; treatment should be discontinued if abnormal symptoms appear. If diarrhea or abdominal pain persists following antibiotic use, membrane colitis should be suspected, and medical personnel should be informed immediately. This drug may cause dizziness; caution is needed when driving or operating machinery. When used with other medications, this may affect renal function, so it should be used in consultation with medical personnel. Pregnant or breastfeeding women should carefully consider the risks and benefits of using this medication. For infants under three months old, safety has not been established, so use should be avoided. Elderly patients may have diminished physiological function, making them more susceptible to adverse reactions, and dosages and intervals should be adjusted accordingly. In cases of overdose, seizures may occur, so it is important to adhere strictly to the prescribed dosage. Medicines should be stored out of reach of children and kept in their original containers to maintain safety and efficacy.

• Candidiasis overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• anemia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This medication should be stored in a tightly sealed container to prevent air ingress and is best kept in a cool place below 30 degrees Celsius. Proper storage can help maintain the drug's effectiveness for a longer period.

Appearance

White to cream-colored rectangular film-coated tablets

Package unit

100 tablets (10 tablets/PTP*10)