Medication info
Clarithromycin 250 mg Tablet

Clarithromycin 250 mg Tablet

Prescription medicationTabletOral
Ingredient · strength
Clarithromycin›0.334mg / 1 tablet
Manufacturer / importer
Shinpoong Pharmaceutical Co., Ltd.
Appearance
Oval-shaped film-coated tablet with a vanilla flavor and yellow color
Packaging
30 tablets/bottle, 100 tablets/bottle
Approval status
Active

MFDS item code 200300015 · Approved 2003.07.24 · Insurance code 648503590

Summary

Main use
Treatment of infections (respiratory, skin, and mycobacterial infections) and Helicobacter pylori eradication in duodenal ulcer
Who takes it
Adults · Children
Adult dose
Clarithromycin is usually administered at a dose of 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7~14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily; for severe infections, administer 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily together with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1~14), and omeprazole 40mg once daily for 28 days (days 1~28).
Child dose
Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

Ingredients

Manufacturer
Shinpoong Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of infections (respiratory, skin, and mycobacterial infections) and Helicobacter pylori eradication in duodenal ulcer

  • Bronchitis
  • pneumonia
  • pharyngitis
  • sinusitis
  • skin and skin tissue infections
  • mycobacterial infections
  • duodenal ulcers
View approved original text

This medication is effective against various bacteria including Staphylococcus aureus and Streptococcus pneumoniae, and is used for treating lower respiratory tract infections such as bronchitis and pneumonia, as well as upper respiratory tract infections like pharyngitis and sinusitis. It is also effective for infections of the skin and skin tissues, and mycobacterial infections, particularly those caused by Mycobacterium avium and intracellular infections. It helps to eradicate Helicobacter pylori in patients with duodenal ulcers, thereby improving symptoms. This medication aids in the treatment of infections caused by multiple pathogens, supporting recovery of health.

How to take

Adult dose

Clarithromycin is usually administered at a dose of 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7~14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily; for severe infections, administer 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily together with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1~14), and omeprazole 40mg once daily for 28 days (days 1~28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

Precautions

This medication should not be used in patients with allergies to certain excipients. Patients who have had hypersensitivity reactions to clarithromycin or other antibiotics in the same class should also avoid its use. It is important to avoid co-administration with certain medications that can cause cardiac rhythm disturbances, as this may pose risks. It is advisable not to use this drug in patients with cardiac arrhythmias, severe liver disease, or significant renal impairment. Pregnant or breastfeeding women, children, and certain genetically lactose-intolerant individuals should refrain from using this medication. The drug can affect liver and kidney function, so patients with liver or kidney disease should consult a physician before using this medication. During treatment, various side effects such as allergic reactions, rash, digestive disturbances, heart issues, neurological symptoms, etc., may occur, and any unusual symptoms should be reported to healthcare providers immediately. It is crucial to administer the minimal necessary duration to prevent the development of antibiotic-resistant bacteria, and prolonged use may disrupt intestinal flora, causing diarrhea or colitis. As there are many drug interactions, it is essential to inform healthcare providers of any other medications being taken, particularly with heart medications, hypoglycemics, anticoagulants, and certain sedatives. In case of overdose, gastrointestinal disturbances or neurological symptoms may occur, requiring immediate medical attention. This medication may require dosage adjustments for children, the elderly, and patients with impaired liver or renal function, and should be taken following medical advice. Caution should be exercised when driving or operating machinery during treatment, and if any unusual symptoms arise after taking the medication, administration should be stopped immediately and a doctor should be consulted.

Side effects

  • Shock
  • anaphylactic symptoms
  • dyspnea
  • convulsions
  • erythema
  • rash
  • pruritus
  • urticaria
  • skin erythema
  • angioedema
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  • joint swelling
  • drug eruption
  • abdominal distension
  • nausea
  • vomiting
  • dyspepsia
  • abdominal pain
  • malaise
  • flatulence
  • diarrhea
  • oral mucosal erosion
  • epigastric pain
  • thirst
  • tooth discoloration
  • pancreatitis
  • increased amylase
  • dysgeusia
  • anorexia
  • constipation
  • stool discoloration
  • membranous colitis
  • hemorrhagic colitis
  • fever
  • cough
  • eosinophilia
  • eosinophilic lung infiltrates
  • interstitial pneumonia
  • chronic bronchitis
  • acute maxillary sinusitis
  • eosinophilia
  • thrombocytopenia
  • pancytopenia
  • hemolytic anemia
  • leukopenia
  • agranulocytosis
  • dizziness
  • depression
  • loss of taste
  • loss of smell
  • anxiety
  • insomnia
  • nightmares
  • tinnitus
  • confusion
  • disorientation
  • hallucinations
  • psychosis
  • depersonalization
  • tremors
  • paresthesia
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • allergic purpura
  • drug rash (DRESS)
  • jaundice
  • hepatocellular hepatitis
  • cholestatic hepatitis
  • increased liver enzyme levels
  • liver dysfunction
  • liver failure
  • fulminant hepatitis
  • elevated AST
  • elevated ALT
  • elevated γ-GTP
  • elevated LDH
  • elevated ALP
  • increased total bilirubin
  • elevated serum creatinine
  • elevated BUN
  • interstitial nephritis
  • renal failure
  • rhabdomyolysis
  • glossitis
  • stomatitis
  • oral candidiasis
  • QT prolongation
  • ventricular tachycardia
  • Torsades de pointes
  • fatigue
  • headache
  • dysgeusia
  • hearing loss
  • paresthesia
  • arthralgia
  • myalgia
  • olfactory disturbances
  • tinnitus
  • auditory impairment
  • hypoglycemia
  • tinnitus
  • hearing impairment
  • vomiting
  • purpuric rash
  • acute generalized pustular dermatitis
  • vasodilation
  • bleeding
  • asthma
  • epistaxis
  • pulmonary embolism
  • esophagitis
  • gastroesophageal reflux disease
  • gastritis
  • rectal pain
  • belching
  • bloating
  • acute pancreatitis
  • tongue discoloration
  • sweating
  • vesicular dermatitis
  • papular rash
  • acne
  • Henoch-Schönlein purpura
  • muscle cramps
  • musculoskeletal stiffness
  • myopathy
  • elevated blood urea nitrogen
  • injection site phlebitis
  • injection site pain
  • injection site inflammation
  • fever
  • weakness
  • chest pain
  • chills
  • fatigue
  • abnormal albumin-globulin ratio
  • elevated serum alkaline phosphatase
  • elevated serum lactate dehydrogenase
  • increased international normalized ratio
  • prolonged prothrombin time
  • abnormal urine color
  • changes in mental status
  • obsessive behavior
  • hypokalemia
  • hypoxemia

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light and should be stored in a dark container. Additionally, it is best to keep it at room temperature between 1°C and 30°C. Proper storage helps maintain the drug's efficacy for a longer period.

Appearance and packaging

Appearance

Oval-shaped film-coated tablet with a vanilla flavor and yellow color

Package unit

30 tablets/bottle, 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.