B. Braun 5% Dextrose Injection

Adult administration

Administer 500∼1000 mL by intravenous injection at a time. The rate of intravenous infusion should not exceed 0.5 g/kg per hour as glucose. Use an appropriate amount for the dissolution and dilution of the injectable medication. Adjust according to age and condition as necessary.

This medication should be handled with care when using glass ampoules. If glass fragments mix in while breaking the ampoule, it may cause harmful reactions, so extra caution should be taken, especially for children and the elderly. This medication contains glucose, which can increase the consumption of Vitamin B1 (thiamine) in the body during intravenous administration. Therefore, there is a risk of severe Vitamin B1 deficiency, and caution is needed. This medication should not be used in patients with certain conditions, such as storage dehydration, fluid overload, hyperglycemia, acidosis, hypokalemia, and glucose intolerance. It should also not be administered to patients with hypersensitivity to this drug. Patients at risk of potassium, phosphate, or magnesium deficiency, those with impaired kidney function, heart failure patients, or those with severe malnutrition should use this medication cautiously and frequently monitor their electrolyte status. Rapid or excessive administration of this medication can cause electrolyte imbalances, and there is a risk of elevated bilirubin and lactic acid levels in the blood. Additionally, side effects such as hypokalemia, hyperosmolar coma, acidosis, dehydration, and polyuria may occur. When administered intravenously, fluid overload or electrolyte imbalances, pulmonary edema, etc., may occur, so caution is advised. Patients with glucose intolerance may experience hyperglycemia and renal impairment. Prolonged use of this medication may affect insulin secretion, so insulin should be administered if necessary. Blood sugar control must be thorough in patients after surgery or trauma and in those with glucose intolerance. During administration of this medication, serum electrolyte tests, fluid balance, and blood glucose levels should be regularly monitored, as well as levels of potassium and phosphate in the blood. The safety of this medication during pregnancy is not certain; thus, it should only be used after carefully considering the risks to the fetus and the therapeutic benefits. Administration during labor may cause issues such as hyperglycemia or hypoglycemia for both the mother and the newborn. Newborns, especially preterm or low-birth-weight infants, are at a higher risk of hypoglycemia or hyperglycemia, so blood glucose should be closely monitored, as hypoglycemia can lead to serious brain damage. Elderly patients should be especially cautious when using this medication due to reduced physical functions. Excessive administration may lead to symptoms of hyperglycemia or diabetes, in which case insulin therapy may be necessary. If excessive amounts are administered subcutaneously, blood circulation issues and exacerbated local irritation may occur; therefore, this should be avoided. Unused medication should be discarded after opening. To reduce the risk of infection when administering injections, cleanliness should be maintained, and it should be warmed to body temperature if cold. Abrupt discontinuation of high-concentration solutions may cause hypoglycemia; therefore, it should be tapered off gradually. Chemical or physical reactions may occur when this medication is mixed with other drugs, so it should be used immediately after mixing, and any adverse reactions should be carefully monitored. Air entering the injection container can cause air embolism, so caution is advised to avoid air when administering continuously.

Mild side effects

• Hypokalemia
• hyperosmolar coma
• acidosis
• dehydration
• hyperosmolarity
• polyuria with glucose detection
• fluid or solute overload
• fluid electrolyte imbalance
• congestion
• pulmonary edema

This medication should be stored in a sealed container to prevent air or moisture from entering. It should be kept away from direct sunlight and stored at room temperature that is neither too hot nor too cold.

Appearance

A colorless and transparent infusion solution filled in a polyethylene container

Package unit

100 milliliters/bottle, 500 milliliters/bottle, 1000 milliliters/bottle